Opendata, web and dolomites

ConflictResolution SIGNED

Transcription-replication conflicts in disease and development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ConflictResolution project word cloud

Explore the words cloud of the ConflictResolution project. It provides you a very rough idea of what is the project "ConflictResolution" about.

split    relevance    owing    machineries    apex2    arises    expression    largely    epi    millions    prevent    genes    question    pathological    source    map    sites    cancers    paradigm    local    trigger    model    induce    molecularly    collision    cells    innovative    understudied    endogenous    human    instability    cellular    dna    transcription    transformations    cell    preliminary    resolve    diseases    shift    reprogram    first    data    neurological    rewire    collisions    types    cancer    differ    start    gene    zygotic    aging    decipher    activation    fashion    normal    mechanism    replication    edge    breast    cutting    localized    indicate    inducible    proximity    gap    link    chromatin    molecular    uncovering    single    lack    pioneered    labelling    conflicts    genomes    hypothesize    principles    episomal    epigenetic    mouse    disorders    developmental    genetic    networks    genome    disease    suitable    tractable    unfortunately    embryonic    potent    physical   

Project "ConflictResolution" data sheet

The following table provides information about the project.

Coordinator
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH 

Organization address
address: INGOLSTADTER LANDSTRASSE 1
city: NEUHERBERG
postcode: 85764
website: www.helmholtz-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙497˙530 €
 EC max contribution 1˙497˙530 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2025-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) coordinator 1˙497˙530.00

Map

 Project objective

Genetic and epigenetic instability contribute to cancers, aging, developmental disorders, and neurological diseases, so in-depth understanding how this instability arises is an important question affecting millions in Europe. Physical conflicts between the transcription and DNA replication machineries are a potent endogenous source of this instability. My preliminary data indicate that a single collision can trigger long-term epigenetic changes and affect the normal expression state of genes. I hypothesize that collisions can rewire gene expression networks and lead to cellular transformations relevant to disease and development. Unfortunately, this mechanism is largely understudied owing to the lack of suitable cellular systems to characterize collisions in molecular detail. My proposal will address this key gap in knowledge. I recently pioneered a unique human cell-based episomal system to analyse collisions in an inducible and localized fashion. Using this highly tractable system, we will molecularly characterize the (epi)genetic consequences and identify novel factors that prevent or resolve collisions (Aim 1). To address the relevance of collisions in disease, we will establish a novel proximity-labelling system (Split-APEX2) to map collision sites and identify their associated genetic and chromatin changes in a breast cancer cell model. This cutting-edge technology will decipher their role in pathological transformations observed in breast cancer genomes (Aim 2). To link collisions to developmental transformations, we will determine their potential to induce local epigenetic changes during zygotic genome activation in mouse embryonic cells. This approach can shift the paradigm how cells in development first start to differ from each other and reprogram their genome into different cell types (Aim 3). Uncovering the key principles of collisions may implement highly innovative approaches to avoid or establish cellular transformations in disease and development.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CONFLICTRESOLUTION" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CONFLICTRESOLUTION" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

NanoPD_P (2020)

High throughput multiplexed trace-analyte screening for diagnostics applications

Read More  

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More  

RTMFRM (2019)

Room Temperature Magnetic Resonance Force Microscopy

Read More