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DecodeDegRNA SIGNED

Post-transcriptional regulation of RNA degradation in early zebrafish development

Total Cost €

0

EC-Contrib. €

0

Partnership

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 DecodeDegRNA project word cloud

Explore the words cloud of the DecodeDegRNA project. It provides you a very rough idea of what is the project "DecodeDegRNA" about.

sequences    living    globally    assays    limit    rna    types    regulatory    principles    model    expressed    time    vast    functions    biological    physiological    gene    maternal    regulation    inside    interactions    place    stimuli    ideal    event    transition    elicit    systematic    basic    arising    limited    expression    embryo    largely    right    protein    efforts    native    roles    implications    death    genomic    understand    technologies    resolution    mechanisms    diverse    heart    cell    broadly    transcriptional    anecdotal    investigation    mrnas    difficulties    strive    vivo    code    disease    single    reveal    small    predictive    massive    applicable    contexts    lies    molecular    environmental    embryos    silencing    birth    predict    cells    genes    carefully    transcription    zebrafish    models    developmental    functional    first    fundamental    ranging    animals    experimental    populations    uncover    embryonic    underlie    degradation    decipher    decode    lack    relies    determines    engineering    final    molecule   

Project "DecodeDegRNA" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 1˙500˙000.00

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 Project objective

Regulation of gene expression lies at the heart of fundamental biological processes, such as the formation of different cell types inside an embryo or responses to environmental stimuli. Living cells ensure that the right genes are expressed at the right time and place by carefully controlling every RNA molecule inside a cell from its ‘birth’ by transcription to its final ‘death’ by degradation. While vast efforts strive to understand the first part of this process – transcription, studies of RNA degradation have been more limited. Current knowledge largely relies on small-scale investigation of key – but anecdotal – cases, while technical and experimental difficulties limit its large-scale analysis. Therefore, we still lack a systematic and predictive understanding of RNA degradation: technologies to globally measure it, the molecular mechanisms involved, its functional and physiological implications and models to decode and predict it. Transcriptional silencing makes early embryos an ideal system to study RNA degradation and uncover its basic concepts, as I propose here. Aim 1 will decipher how genomic information within native RNA sequences determines their degradation in embryos. Aim 2 will develop the technology to investigate RNA degradation at single-cell resolution, and uncover its regulation within arising embryonic cell populations. Aim 3 will reveal the molecular implementation of the regulatory code of RNA degradation and determine its physiological roles that underlie the massive degradation of maternal mRNAs – a key regulatory event and a main developmental transition in early embryos of all animals. This work will uncover new principles of RNA degradation in early development and elicit its mechanisms and functions using the zebrafish as an in vivo model system. The assays and models to be developed will be broadly applicable to study RNA degradation in diverse contexts, ranging from disease mechanisms to engineering of RNA- protein interactions.

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The information about "DECODEDEGRNA" are provided by the European Opendata Portal: CORDIS opendata.

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