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HCA Organoid SIGNED

HCA|Organoid: Pilot action to establish a multi-tissue human organoid platform within the Human Cell Atlas as a booster of future disease-centric, mechanistic, and translational research

Total Cost €

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EC-Contrib. €

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Partnership

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 HCA Organoid project word cloud

Explore the words cloud of the HCA Organoid project. It provides you a very rough idea of what is the project "HCA Organoid" about.

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Project "HCA Organoid" data sheet

The following table provides information about the project.

Coordinator
CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH 

Organization address
address: LAZARETTGASSE 14 AKH BT 25.3
city: WIEN
postcode: 1090
website: http://www.oeaw.ac.at/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 4˙998˙687 €
 EC max contribution 4˙998˙687 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH AT (WIEN) coordinator 1˙111˙597.00
2    PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV NL (UTRECHT) participant 923˙125.00
3    DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DE (HEIDELBERG) participant 809˙250.00
4    STICHTING HUBRECHT ORGANOID TECHNOLOGY NL (UTRECHT) participant 679˙463.00
5    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) participant 634˙475.00
6    INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH AT (WIEN) participant 610˙748.00
7    EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH DE (ST INGBERT) participant 160˙250.00
8    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 69˙777.00

Map

 Project objective

'Excellence: The Human Cell Atlas (HCA) is descriptive by definition, as it seeks to map all cells in the human body. Yet its goal of “understanding fundamental human biological processes and diagnosing, monitoring, and treating disease” (HCA Whitepaper) depends on our ability to draw functional/causal/mechanistic conclusions relevant to human diseases. Personalized organoid technology aptly fills this gap, as it makes human tissue amenable to functional studies and faithful disease modeling in vitro.

This project will firmly establish a 'Human Organoid Atlas' within the HCA. Initially focusing on two organs (colon and brain: 100 persons each) additional organs will be included as pilot studies with organoids derived from up to 20 individuals in total. It is, for example, envisioned that pancreas organoids will be included in collaboration with Human Cell Atlas affiliated projects that focus on the single-cell dissection of the human pancreas. We will establish single-cell transcriptomes, single-cell epigenomes, and time-series imaging for several thousand organoids and matched primary tissue. This resource will quantify normal population variation and provide a baseline for disease studies. We will show its practical utility by proof-of-concept disease modeling for genetic epilepsy (brain) and large-scale characterization of disease-linked genetic variants (colon).

Impact: 1. Deeply characterized organoid collection enables functional and disease-centric studies pursuing HCA insights. 2. Single-cell dataset provides reference of population variation under highly standardized conditions. 3. Linking single-cell profiling and organoids will boost HCA’s impact on human health.

Implementation: The project connects the European founders of organoid research (Hans Clevers, Jürgen Knoblich) with expertise in large-scale epigenome/transcriptome profiling (Christoph Bock, Henk Stunnenberg), advanced imaging (Prisca Liberali, Anne Rios), bioinformatics and systems genetics (Oliver Stegle, Michael Boutros), data management (Laura Clarke/EBI), and strong SME contribution (Hubrecht Organoid Technology, Eurice). The project is fully committed to the HCA's values. It implements extensive data sharing and sustainability measures.'

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The information about "HCA ORGANOID" are provided by the European Opendata Portal: CORDIS opendata.

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