Opendata, web and dolomites

HCA Organoid SIGNED

HCA|Organoid: Pilot action to establish a multi-tissue human organoid platform within the Human Cell Atlas as a booster of future disease-centric, mechanistic, and translational research

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 HCA Organoid project word cloud

Explore the words cloud of the HCA Organoid project. It provides you a very rough idea of what is the project "HCA Organoid" about.

boost    single    variation    resource    clarke    gap    organoids    time    quantify    oliver    treating    hubrecht    diagnosing    genetics    stegle    practical    bock    persons    clevers    committed    aptly    imaging    diseases    additional    brain    organs    total    deeply    christoph    initially    primary    variants    matched    epigenome    linking    modeling    thousand    human    personalized    profiling    pancreas    whitepaper    standardized    normal    prisca    henk    body    fundamental    colon    linked    contribution    bioinformatics    liberali    uuml    cells    expertise    descriptive    rios    population    utility    transcriptomes    biological    michael    disease    dissection    fills    centric    health    causal    laura    tissue    pursuing    series    hans    draw    definition    provides    monitoring    hca    individuals    ebi    mechanistic    organoid    faithful    implements    reference    proof    eurice    map    depends       collection    dataset    baseline    genetic    atlas    excellence    stunnenberg    founders    envisioned    amenable    functional    data    characterization    sme    transcriptome    knoblich    boutros    affiliated    rgen    cell    sustainability    anne    epilepsy    connects    extensive    insights    firmly    pilot    vitro    epigenomes    sharing   

Project "HCA Organoid" data sheet

The following table provides information about the project.

Coordinator
CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH 

Organization address
address: LAZARETTGASSE 14 AKH BT 25.3
city: WIEN
postcode: 1090
website: http://www.oeaw.ac.at/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 4˙998˙687 €
 EC max contribution 4˙998˙687 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH AT (WIEN) coordinator 1˙111˙597.00
2    PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV NL (UTRECHT) participant 923˙125.00
3    DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DE (HEIDELBERG) participant 809˙250.00
4    STICHTING HUBRECHT ORGANOID TECHNOLOGY NL (UTRECHT) participant 679˙463.00
5    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) participant 634˙475.00
6    INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH AT (WIEN) participant 610˙748.00
7    EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH DE (ST INGBERT) participant 160˙250.00
8    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 69˙777.00

Map

 Project objective

'Excellence: The Human Cell Atlas (HCA) is descriptive by definition, as it seeks to map all cells in the human body. Yet its goal of “understanding fundamental human biological processes and diagnosing, monitoring, and treating disease” (HCA Whitepaper) depends on our ability to draw functional/causal/mechanistic conclusions relevant to human diseases. Personalized organoid technology aptly fills this gap, as it makes human tissue amenable to functional studies and faithful disease modeling in vitro.

This project will firmly establish a 'Human Organoid Atlas' within the HCA. Initially focusing on two organs (colon and brain: 100 persons each) additional organs will be included as pilot studies with organoids derived from up to 20 individuals in total. It is, for example, envisioned that pancreas organoids will be included in collaboration with Human Cell Atlas affiliated projects that focus on the single-cell dissection of the human pancreas. We will establish single-cell transcriptomes, single-cell epigenomes, and time-series imaging for several thousand organoids and matched primary tissue. This resource will quantify normal population variation and provide a baseline for disease studies. We will show its practical utility by proof-of-concept disease modeling for genetic epilepsy (brain) and large-scale characterization of disease-linked genetic variants (colon).

Impact: 1. Deeply characterized organoid collection enables functional and disease-centric studies pursuing HCA insights. 2. Single-cell dataset provides reference of population variation under highly standardized conditions. 3. Linking single-cell profiling and organoids will boost HCA’s impact on human health.

Implementation: The project connects the European founders of organoid research (Hans Clevers, Jürgen Knoblich) with expertise in large-scale epigenome/transcriptome profiling (Christoph Bock, Henk Stunnenberg), advanced imaging (Prisca Liberali, Anne Rios), bioinformatics and systems genetics (Oliver Stegle, Michael Boutros), data management (Laura Clarke/EBI), and strong SME contribution (Hubrecht Organoid Technology, Eurice). The project is fully committed to the HCA's values. It implements extensive data sharing and sustainability measures.'

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HCA ORGANOID" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "HCA ORGANOID" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.3.1.1.)

ESPACE (2020)

Human Cell Atlas of the Pancreas

Read More  

CANDY (2020)

Comorbid Analysis of Neurodevelopmental Disorders and Epilepsy

Read More  

BIND (2020)

Brain Involvement iN Dystrophinopathies

Read More