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discovAIR SIGNED

Discovering the cellular landscape of the airways and the lung

Total Cost €

EC-Contrib. €

Partnership

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discovAIR project word cloud

Explore the words cloud of the discovAIR project. It provides you a very rough idea of what is the project "discovAIR" about.

tissue phenotypes active incidence precision sustainability health multimodal expressing hampered human limitation chart branches urgently ageing perturbation reconstruction transitions therapeutic lung basic evidenced diagnostic map interactions clinical ipf thereby overcome architecture first atlas effort progress asthma living community pharmaceutical visualization regenerative spatial patients cftr candidates copd translational cell computational platform cellular data multilevel fixed disease combine identification neighbourhoods cells incomplete shared phenotyping organization integrate herein mapping curative death experimental local industry molecular ionocyte profiling discovair macroscopic diagnostics scientific infrastructure lack diseases complexity medicine acquire exploration 3d interventions healthy

Project "discovAIR" data sheet

The following table provides information about the project.

Coordinator	ACADEMISCH ZIEKENHUIS GRONINGEN Organization address address: HANZEPLEIN 1 city: GRONINGEN postcode: 9713 GZ website: www.umcg.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	4˙958˙682 €
EC max contribution	4˙958˙682 € (100%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-SC1-2019-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ACADEMISCH ZIEKENHUIS GRONINGEN ACADEMISCH ZIEKENHUIS GRONINGEN Organization address address: HANZEPLEIN 1 city: GRONINGEN postcode: 9713 GZ website: www.umcg.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	coordinator	658˙951.00
2	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Organization address address: INGOLSTADTER LANDSTRASSE 1 city: NEUHERBERG postcode: 85764 website: www.helmholtz-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (NEUHERBERG)	participant	683˙418.00
3	GENOME RESEARCH LIMITED GENOME RESEARCH LIMITED Organization address address: THE GIBBS BUILDING, EUSTON ROAD 215 city: LONDON postcode: NW1 2BE website: http://www.sanger.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	653˙316.00
4	RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN Organization address address: REGINA PACIS WEG 3 city: BONN postcode: 53113 website: www.uni-bonn.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BONN)	participant	477˙888.00
5	STOCKHOLMS UNIVERSITET STOCKHOLMS UNIVERSITET Organization address address: UNIVERSITETSVAGEN 10 city: STOCKHOLM postcode: 10691 website: www.su.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	427˙225.00
6	COMMA SOFT AG COMMA SOFT AG Organization address address: PUTZCHENS CHAUSSEE 202-204A city: BONN postcode: 53229 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BONN)	participant	418˙125.00
7	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	373˙760.00
8	SZEGEDI BIOLOGIAI KUTATOKOZPONT SZEGEDI BIOLOGIAI KUTATOKOZPONT Organization address address: TEMESVARI KORUT 62 city: SZEGED postcode: 6726 website: www1.szbk.u-szeged.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (SZEGED)	participant	284˙125.00
9	EUROPEAN MOLECULAR BIOLOGY LABORATORY EUROPEAN MOLECULAR BIOLOGY LABORATORY Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 website: http://www.embl.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	237˙213.00
10	KUNGLIGA TEKNISKA HOEGSKOLAN KUNGLIGA TEKNISKA HOEGSKOLAN Organization address address: BRINELLVAGEN 8 city: STOCKHOLM postcode: 100 44 website: www.kth.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	195˙625.00
11	CARTANA AB CARTANA AB Organization address address: NOBELS VAG 3 city: SOLNA postcode: 171 65 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (SOLNA)	participant	172˙125.00
12	CENTRE HOSPITALIER UNIVERSITAIRE DE NICE CENTRE HOSPITALIER UNIVERSITAIRE DE NICE Organization address address: AVENUE VICTORIA 4 city: NICE postcode: 6003 website: www.chu-nice.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (NICE)	participant	162˙725.00
13	EUROPEAN RESPIRATORY SOCIETY EUROPEAN RESPIRATORY SOCIETY Organization address address: AVENUE SAINTE LUCE 4 city: LAUSANNE postcode: 1003 website: www.ersnet.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	110˙406.00
14	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	70˙590.00
15	EUROPEAN LUNG FOUNDATION EUROPEAN LUNG FOUNDATION Organization address address: GLOSSOP ROAD 442 city: SHEFFIELD postcode: S10 2PX website: www.european-lung-foundation.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SHEFFIELD)	participant	33˙187.00

Map

Project objective

Lung diseases are a leading cause of death, with increasing incidence and lack of curative interventions. The development of novel therapeutic interventions is hampered by our incomplete knowledge of the cellular complexity of the lung, as evidenced by the recent identification of the CFTR-expressing ionocyte. To overcome this limitation, we urgently need to acquire detailed knowledge of the cells of the lung, their fixed and variable molecular features, their interactions and their organization into macroscopic tissue architecture in health and disease. To achieve this, discovAIR aims to establish the first draft of the Human Lung Cell Atlas. Herein, discovAIR will combine multimodal molecular profiling of lung tissue cells with a detailed spatial mapping of the identified cell states, 3D reconstruction of lung tissue architecture, and in-depth molecular phenotyping of local cellular neighbourhoods. We will develop novel computational approaches to integrate the multilevel data of the spatial and the cellular branches of discovAIR. To identify the molecular phenotypes of cells in disease, discovAIR will include lung tissue from patients with asthma, COPD and IPF in the molecular profiling and spatial mapping effort. Moreover, discovAIR will chart cell state transitions from health to disease in a novel experimental approach, the lung cell perturbation map. The discovAIR results will be shared with the basic, translational and clinical scientific community as well as diagnostic and pharmaceutical industry through and open-access data visualization and exploration platform. For sustainability, this platform will be embedded in the Human Cell Atlas infrastructure. The discovAIR results will facilitate progress in regenerative and precision medicine and identify novel candidates for precision diagnostics and curative interventions in lung disease, thereby contributing to healthy ageing and active living in Europe.

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The information about "DISCOVAIR" are provided by the European Opendata Portal: CORDIS opendata.