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discovAIR SIGNED

Discovering the cellular landscape of the airways and the lung

Total Cost €

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EC-Contrib. €

0

Partnership

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 discovAIR project word cloud

Explore the words cloud of the discovAIR project. It provides you a very rough idea of what is the project "discovAIR" about.

chart    transitions    atlas    platform    lack    diagnostics    experimental    ipf    medicine    multilevel    ionocyte    architecture    macroscopic    living    effort    profiling    exploration    overcome    pharmaceutical    visualization    clinical    identification    precision    urgently    expressing    discovair    asthma    mapping    fixed    active    cell    map    curative    perturbation    cellular    incomplete    data    local    hampered    computational    acquire    molecular    organization    tissue    interventions    3d    limitation    industry    ageing    complexity    interactions    health    cells    combine    regenerative    multimodal    human    scientific    phenotypes    translational    branches    candidates    therapeutic    disease    integrate    death    basic    copd    shared    evidenced    infrastructure    herein    cftr    incidence    diseases    healthy    reconstruction    spatial    neighbourhoods    first    diagnostic    progress    sustainability    phenotyping    community    lung    thereby    patients   

Project "discovAIR" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS GRONINGEN 

Organization address
address: HANZEPLEIN 1
city: GRONINGEN
postcode: 9713 GZ
website: www.umcg.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 4˙958˙682 €
 EC max contribution 4˙958˙682 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS GRONINGEN NL (GRONINGEN) coordinator 658˙951.00
2    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) participant 683˙418.00
3    GENOME RESEARCH LIMITED UK (LONDON) participant 653˙316.00
4    RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN DE (BONN) participant 477˙888.00
5    STOCKHOLMS UNIVERSITET SE (STOCKHOLM) participant 427˙225.00
6    COMMA SOFT AG DE (BONN) participant 418˙125.00
7    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 373˙760.00
8    SZEGEDI BIOLOGIAI KUTATOKOZPONT HU (SZEGED) participant 284˙125.00
9    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 237˙213.00
10    KUNGLIGA TEKNISKA HOEGSKOLAN SE (STOCKHOLM) participant 195˙625.00
11    CARTANA AB SE (SOLNA) participant 172˙125.00
12    CENTRE HOSPITALIER UNIVERSITAIRE DE NICE FR (NICE) participant 162˙725.00
13    EUROPEAN RESPIRATORY SOCIETY CH (LAUSANNE) participant 110˙406.00
14    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 70˙590.00
15    EUROPEAN LUNG FOUNDATION UK (SHEFFIELD) participant 33˙187.00

Map

 Project objective

Lung diseases are a leading cause of death, with increasing incidence and lack of curative interventions. The development of novel therapeutic interventions is hampered by our incomplete knowledge of the cellular complexity of the lung, as evidenced by the recent identification of the CFTR-expressing ionocyte. To overcome this limitation, we urgently need to acquire detailed knowledge of the cells of the lung, their fixed and variable molecular features, their interactions and their organization into macroscopic tissue architecture in health and disease. To achieve this, discovAIR aims to establish the first draft of the Human Lung Cell Atlas. Herein, discovAIR will combine multimodal molecular profiling of lung tissue cells with a detailed spatial mapping of the identified cell states, 3D reconstruction of lung tissue architecture, and in-depth molecular phenotyping of local cellular neighbourhoods. We will develop novel computational approaches to integrate the multilevel data of the spatial and the cellular branches of discovAIR. To identify the molecular phenotypes of cells in disease, discovAIR will include lung tissue from patients with asthma, COPD and IPF in the molecular profiling and spatial mapping effort. Moreover, discovAIR will chart cell state transitions from health to disease in a novel experimental approach, the lung cell perturbation map. The discovAIR results will be shared with the basic, translational and clinical scientific community as well as diagnostic and pharmaceutical industry through and open-access data visualization and exploration platform. For sustainability, this platform will be embedded in the Human Cell Atlas infrastructure. The discovAIR results will facilitate progress in regenerative and precision medicine and identify novel candidates for precision diagnostics and curative interventions in lung disease, thereby contributing to healthy ageing and active living in Europe.

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The information about "DISCOVAIR" are provided by the European Opendata Portal: CORDIS opendata.

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