Explore the words cloud of the ImmunoSep project. It provides you a very rough idea of what is the project "ImmunoSep" about.
The following table provides information about the project.
STICHTING KATHOLIEKE UNIVERSITEIT
|Coordinator Country||Netherlands [NL]|
|Total cost||10˙081˙333 €|
|EC max contribution||10˙081˙333 € (100%)|
1. H2020-EU.3.1.3. (Treating and managing disease)
|Duration (year-month-day)||from 2020-01-01 to 2023-12-31|
Take a look of project's partnership.
|1||STICHTING KATHOLIEKE UNIVERSITEIT||NL (NIJMEGEN)||coordinator||1˙660˙226.00|
|2||ELLINIKO INSTITUTO MELETIS TIS SIPSIS||EL (ATHENS)||participant||1˙700˙000.00|
|3||ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM||NL (AMSTERDAM)||participant||950˙000.00|
|4||HOSPICES CIVILS DE LYON||FR (LYON)||participant||760˙080.00|
|5||CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS||CH (LAUSANNE)||participant||760˙000.00|
|6||Universitätsklinikum Jena||DE (Jena)||participant||759˙875.00|
|7||RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN||DE (BONN)||participant||505˙881.00|
|8||CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH||AT (WIEN)||participant||499˙715.00|
|9||UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA||RO (Cluj-Napoca)||participant||460˙001.00|
|10||BIOASTER FONDATION DE COOPERATION SCIENTIFIQUE||FR (LYON)||participant||436˙270.00|
|11||EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH||DE (ST INGBERT)||participant||402˙625.00|
|12||TEL AVIV UNIVERSITY||IL (TEL AVIV)||participant||399˙975.00|
|13||BIOMERIEUX SA||FR (Marcy l'Etoile)||participant||399˙685.00|
|14||THE UNIVERSITY OF READING||UK (READING)||participant||387˙000.00|
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, and is characterized by a high mortality of up to 30-40%. Treatment of sepsis was revolutionized by two steps that significantly decreased mortality: antibiotics and the intensive care units. It has been hoped that a third revolution, immunotherapy, would further improve outcome of sepsis, but this hope did not materialize. This was due to the incompletely understood pathophysiology, and the heterogeneity of the immune status in different sepsis patients. We propose that while both overinflammation and immunoparalysis are important, they are present in individual sepsis patients.The mission of the present project is to design and perform a proof-of-concept clinical trial of personalized immunotherapy in sepsis, and within this clinical trial, to develop a next-generation theranostics platform for the design of future personalized immunotherapy trials in sepsis. This theranostics platform would be based on an integrated, multidimensional systems biology analysis of omics-based datasets, to identify biomarkers, clinical endotypes, and therapeutic targets for precision medicine approaches. In order to achieve the mission proposed, several complementary aims will be pursued: Aim 1: To design and perform a large personalized immunotherapy trial in sepsis patients, that can provide a clinical answer towards the usefulness of currently employed immunotherapies for sepsis. Aim 2: To chart host genome, epigenome, transcriptome, metabolome and microbiome in at least 180 sepsis patients enrolled in Aim 1 over a defined time course. Aim 3: To use a theranostics approach based on the data provided by Aim 2 to design novel personalized immunotherapeutic strategies. Aim 4: To integrate the clinical and psychological aspects involved when introducing novel immunotherapies for infections in the health care systems of European countries, building bridges with the patient community.
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The information about "IMMUNOSEP" are provided by the European Opendata Portal: CORDIS opendata.
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