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ENDFLU SIGNED

Evaluation of ratioNally Designed Influenza vaccines

Total Cost €

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EC-Contrib. €

0

Partnership

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 ENDFLU project word cloud

Explore the words cloud of the ENDFLU project. It provides you a very rough idea of what is the project "ENDFLU" about.

advocacy    scientific    clinically    constructs    model    generation    vaccination    m2e    rationally    achievements    induces    combination    encoding    expertise    biochemical    manufacturing    humoral    clade    demonstration    gmp    rational    strategies    nanoparticles    clinical    enter    ferrets    toward    compliant    adoption    fusions    construct    india    optimal    mice    vaccine    epitopes    na    designed    candidates    protective    formulation    human    chim    cell    combat    efficacy    mediated    seeds    cross    broadly    elicit    immunogenicity    create    expressed    surface    indian    infection    repository    conserved    protein    functional    criteria    pandemic    proteins    hemagglutinin    stem    combined    assessing    fueled    artificial    optimized    endflu    biophysical    polyepitope    select    dose    complementary    world    internal    ing    head    h5    worldwide    immunity    plan    trial    optimize    manifestations    either    influenza    safety    mva    encode    followed   

Project "ENDFLU" data sheet

The following table provides information about the project.

Coordinator
STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER 

Organization address
address: BUNTEWEG 2
city: HANNOVER
postcode: 30559
website: www.tiho-hannover.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 14˙444˙867 €
 EC max contribution 8˙646˙254 € (60%)
 Programme 1. H2020-EU.3.1.2. (Preventing disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER DE (HANNOVER) coordinator 1˙234˙225.00
2    CURVE CLINICAL BV NL (AMSTERDAM DUIVENDRECHT) participant 3˙364˙571.00
3    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 2˙342˙075.00
4    VIB BE (ZWIJNAARDE - GENT) participant 608˙750.00
5    UNIVERSITEIT UTRECHT NL (UTRECHT) participant 435˙707.00
6    LUNDS UNIVERSITET SE (LUND) participant 360˙925.00
7    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) participant 300˙000.00
8    COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH IN (NEW DEHLI) participant 0.00
9    INDIAN INSTITUTE OF SCIENCE IN (BANGALORE) participant 0.00
10    INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH THIRUVANANTHAPURAM IN (THIRUVANANTHAPURAM) participant 0.00
11    MANIPAL ACADEMY OF HIGHER EDUCATION IN (MANIPAL) participant 0.00
12    MYNVAX PRIVATE LIMITED IN (BANGLADORE) participant 0.00
13    SETH G S M COLLEGE AND K E M HOSPITAL DIAMOND JUBILEE SOCIETY IN (MUMBAI) participant 0.00
14    TRANSLATIONAL HEALTH SCIENCE AND TECHNOLOGY INSTITUTE IN (FARIDABAD) participant 0.00

Map

 Project objective

ENDFLU will develop three complementary next-generation influenza vaccination strategies for the world, fueled by the unique combined expertise of Indian and European partners in rational vaccine design and development: • Create a repository of pre-pandemic GMP-compliant MVA-based vaccine seeds, each encoding an influenza hemagglutinin (HA), based on European partners demonstration of clinical safety and cross-clade immunogenicity of MVA-H5. • Optimize and select protein- and MVA-based constructs developed by Indian and European ENDFLU partners, resulting in a rationally combined vaccine formulation that induces broadly protective humoral and cell-mediated immunity against all influenza manifestations. This will be advanced in a Phase I clinical trial and Controlled Human Infection Model (CHIM) study. • Pre-clinically advance other promising protein- and MVA-based constructs toward future development beyond ENDFLU. Constructs to elicit humoral immunity build on rationally-designed and optimized conserved epitopes of influenza surface proteins, HA stem- and HA head-nanoparticles, and NA-M2e fusions either as proteins or MVA expressed. Other MVA-based constructs to elicit cell-mediated immunity will encode conserved internal protein T cell epitopes, as an artificial polyepitope. The best candidates will be selected based on biochemical, biophysical, functional and manufacturing criteria, and immunogenicity and protective efficacy in mice and ferrets. The selected protein-based construct will enter a Part A Phase I clinical trial in India assessing safety, immunogenicity and optimal dose, to be combined with the selected MVA-based construct. This protein-MVA combination will enter a Part B Phase I clinical trial in the EU, assessing safety and immunogenicity, followed by the CHIM study. A dissemination and exploitation plan, and collaboration with key scientific advocacy organizations will facilitate the adoption of ENDFLU achievements to combat influenza worldwide.

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The information about "ENDFLU" are provided by the European Opendata Portal: CORDIS opendata.

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