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EVOMENS SIGNED

The evolution of menstruation in primates

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EVOMENS project word cloud

Explore the words cloud of the EVOMENS project. It provides you a very rough idea of what is the project "EVOMENS" about.

composition    activated    differentially    advent    emerged    assays    genes    networks    mutational    occurred    gynaecological    regulation    endometrial    underpinnings    regions    mechanisms    understand    linings    shed    human    fecundation    vervets    reabsorbed    single    novelty    lineage    genetic    molecular    uterine    coding    primates    orangutans    transcriptomics    vs    functional    differentiate    discover    instead    humans    acquired    inherited    divergence    interplay    shedding    genomes    baboons    physiological    innovation    cell    dynamics    evolutionary    regulatory    genetically    primate    replace    gene    endometrium    reveal    adoption    somatic    genome    dramatic    populations    critical    uncover    evolution    involvement    cycle    reproduction    chromatin    trait    menstruating    closely    reproductive    menstruation    despite    mammals    levels    elucidate    species    context    latter    accessible    leverage    marker    tissues    reabsorption    deep    cellular    modifications    sorted    tissue    compares   

Project "EVOMENS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙185˙250 €
 EC max contribution 1˙185˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙185˙250.00

Map

 Project objective

Menstruation is a recent evolutionary innovation in primates: the trait is present in some species (humans, baboons) but not in closely related others (orangutans, vervets). In the latter and in most mammals, the uterine endometrium is reabsorbed at the end of the cycle instead of being shed when fecundation has not occurred. The molecular and genetic underpinnings of this complex process are not fully understood, despite its critical involvement in gynaecological conditions. I propose to discover the molecular mechanisms leading to menstruation by comparing the uterine linings from five primate species at the cellular, functional and genetic levels. The objectives are to identify the gene networks and non-coding regulatory elements that control the advent of menstruation in primates, and to understand how this genetically inherited trait was acquired in primate genomes during the evolution of the human lineage. In Aim 1, I will leverage single-cell transcriptomics to uncover the cellular composition and marker modifications that differentiate the uterine linings of menstruating and non-menstruating primates. In Aim 2, I will use deep transcriptomics and accessible chromatin assays on sorted endometrial cell populations to identify genes and non-coding regulatory regions differentially activated in menstruating species. This analysis will reveal the molecular pathways, regulation networks and cellular interplay involved in uterine tissue shedding vs. reabsorption. In Aim 3, I will replace these modifications within the context of primate genome evolution: I will elucidate the mutational dynamics by which genetic novelty has emerged during the adoption of menstruation, and how the functional divergence of the endometrium compares to other reproductive and somatic tissues. This project will enhance our understanding of a key physiological trait for human reproduction as well as a dramatic example of functional innovation in the primate lineage.

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The information about "EVOMENS" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-05-25 22:04:15) correctly updated