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EVOMENS SIGNED

The evolution of menstruation in primates

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EVOMENS project word cloud

Explore the words cloud of the EVOMENS project. It provides you a very rough idea of what is the project "EVOMENS" about.

innovation    tissue    cellular    gene    accessible    baboons    uncover    functional    cycle    understand    replace    lineage    menstruating    activated    reabsorption    regions    differentiate    vs    fecundation    shed    gynaecological    linings    critical    leverage    mammals    levels    divergence    somatic    orangutans    instead    cell    regulation    closely    emerged    mechanisms    evolutionary    trait    assays    menstruation    despite    occurred    networks    differentially    endometrium    acquired    discover    primate    deep    reveal    transcriptomics    endometrial    context    reproductive    vervets    tissues    species    mutational    populations    molecular    latter    uterine    novelty    adoption    chromatin    evolution    regulatory    sorted    primates    composition    genome    genes    reproduction    underpinnings    genetic    physiological    coding    single    advent    reabsorbed    genomes    shedding    marker    dynamics    modifications    involvement    inherited    genetically    dramatic    human    humans    interplay    elucidate    compares   

Project "EVOMENS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙185˙250 €
 EC max contribution 1˙185˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙185˙250.00

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 Project objective

Menstruation is a recent evolutionary innovation in primates: the trait is present in some species (humans, baboons) but not in closely related others (orangutans, vervets). In the latter and in most mammals, the uterine endometrium is reabsorbed at the end of the cycle instead of being shed when fecundation has not occurred. The molecular and genetic underpinnings of this complex process are not fully understood, despite its critical involvement in gynaecological conditions. I propose to discover the molecular mechanisms leading to menstruation by comparing the uterine linings from five primate species at the cellular, functional and genetic levels. The objectives are to identify the gene networks and non-coding regulatory elements that control the advent of menstruation in primates, and to understand how this genetically inherited trait was acquired in primate genomes during the evolution of the human lineage. In Aim 1, I will leverage single-cell transcriptomics to uncover the cellular composition and marker modifications that differentiate the uterine linings of menstruating and non-menstruating primates. In Aim 2, I will use deep transcriptomics and accessible chromatin assays on sorted endometrial cell populations to identify genes and non-coding regulatory regions differentially activated in menstruating species. This analysis will reveal the molecular pathways, regulation networks and cellular interplay involved in uterine tissue shedding vs. reabsorption. In Aim 3, I will replace these modifications within the context of primate genome evolution: I will elucidate the mutational dynamics by which genetic novelty has emerged during the adoption of menstruation, and how the functional divergence of the endometrium compares to other reproductive and somatic tissues. This project will enhance our understanding of a key physiological trait for human reproduction as well as a dramatic example of functional innovation in the primate lineage.

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The information about "EVOMENS" are provided by the European Opendata Portal: CORDIS opendata.

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