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MemDense SIGNED

Cellular control of membrane protein density in the endoplasmic reticulum via the unfolded protein response

Total Cost €

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EC-Contrib. €

0

Partnership

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 MemDense project word cloud

Explore the words cloud of the MemDense project. It provides you a very rough idea of what is the project "MemDense" about.

biophysical    chaperone    endeavor    vivo    characterization    activation    reticulum    diseases    cell    community    folding    mount    senses    homeostatic    density    abundant    perspective    answer    cells    imbalances    radically    unfolded    primed    stress    infections    viral    valuable    er    biology    functions    combination    framework    mechanisms    biochemical    cellular    establishing    memdense    controls    adaptive    sensed    all    strategies    machinery    chronic    proteins    abundance    conceptual    lipid    misfolded    provides    homeostasis    protein    transducers    synthesis    reconstitute    tools    isolation    survival    vitro    almost    sense    metabolism    endoplasmic    upr    decisions    centrally    questions    immuno    apoptosis    genetic    molecular    soluble    central    combining    aberrancies    parallel    crowding    exclusively    controlled    responses    diabetes    sensing    neurodegeneration    organelles    quality    signals    balance    recognition    triggers    membrane    lipids   

Project "MemDense" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT DES SAARLANDES 

Organization address
address: CAMPUS
city: SAARBRUCKEN
postcode: 66123
website: www.uni-saarland.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙934˙065 €
 EC max contribution 1˙934˙065 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT DES SAARLANDES DE (SAARBRUCKEN) coordinator 1˙934˙065.00

Map

 Project objective

All cells must balance the production of proteins and lipids to maintain membrane functions. Imbalances in protein folding and lipid metabolism cause endoplasmic reticulum (ER) stress associated with a wide range of complex diseases including diabetes, neurodegeneration, and viral infections. The central homeostatic program of the ER is the unfolded protein response (UPR), which senses unfolded proteins in the ER to control protein synthesis, chaperone abundance, and lipid metabolism. Through these mechanisms, the UPR centrally controls decisions between cell survival, adaptation, and apoptosis. The field has focused almost exclusively on soluble proteins as triggers of the UPR, while the more abundant membrane proteins have been neglected. Our finding of UPR activation by membrane aberrancies provides a radically new perspective and allows us to address central questions in membrane and cell biology: How is the density of ER membrane proteins sensed and controlled? How are misfolded membrane proteins recognized to mount adaptive responses?

Focusing on the conceptual advance that UPR transducers sense signals from the membrane, we will 1) establish and reconstitute the machinery for sensing membrane protein crowding, 2) identify mechanisms coordinating protein and lipid homeostasis between organelles, 3) study the molecular recognition of misfolded membrane proteins by the UPR.

Key to this endeavor is our unique combination of genetic, biochemical, and biophysical tools for parallel characterization of the UPR in vivo and in vitro. Combining this framework with novel strategies for an immuno-isolation of organelles, we are primed to answer how membrane aberrancies cause chronic ER stress. By establishing the UPR as a quality control system for membrane proteins, and providing novel tools and valuable resources to the community, MemDense will have wide impact on our molecular and cellular understanding of ER homeostasis and the many diseases related to ER stress.

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The information about "MEMDENSE" are provided by the European Opendata Portal: CORDIS opendata.

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