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MemDense SIGNED

Cellular control of membrane protein density in the endoplasmic reticulum via the unfolded protein response

Total Cost €

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EC-Contrib. €

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Partnership

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 MemDense project word cloud

Explore the words cloud of the MemDense project. It provides you a very rough idea of what is the project "MemDense" about.

density    abundance    signals    metabolism    homeostasis    vitro    framework    neurodegeneration    conceptual    synthesis    genetic    diabetes    mount    unfolded    valuable    crowding    sense    immuno    characterization    memdense    adaptive    radically    chronic    functions    viral    combining    cellular    cells    stress    biochemical    sensing    primed    upr    er    diseases    vivo    endeavor    chaperone    parallel    centrally    reticulum    aberrancies    proteins    controlled    community    responses    lipid    transducers    infections    all    triggers    recognition    sensed    misfolded    questions    homeostatic    tools    senses    imbalances    almost    molecular    isolation    strategies    quality    balance    biophysical    establishing    decisions    membrane    cell    lipids    reconstitute    combination    central    soluble    organelles    activation    apoptosis    answer    mechanisms    protein    biology    perspective    machinery    controls    endoplasmic    provides    folding    exclusively    abundant    survival   

Project "MemDense" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT DES SAARLANDES 

Organization address
address: CAMPUS
city: SAARBRUCKEN
postcode: 66123
website: www.uni-saarland.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙934˙065 €
 EC max contribution 1˙934˙065 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT DES SAARLANDES DE (SAARBRUCKEN) coordinator 1˙934˙065.00

Map

 Project objective

All cells must balance the production of proteins and lipids to maintain membrane functions. Imbalances in protein folding and lipid metabolism cause endoplasmic reticulum (ER) stress associated with a wide range of complex diseases including diabetes, neurodegeneration, and viral infections. The central homeostatic program of the ER is the unfolded protein response (UPR), which senses unfolded proteins in the ER to control protein synthesis, chaperone abundance, and lipid metabolism. Through these mechanisms, the UPR centrally controls decisions between cell survival, adaptation, and apoptosis. The field has focused almost exclusively on soluble proteins as triggers of the UPR, while the more abundant membrane proteins have been neglected. Our finding of UPR activation by membrane aberrancies provides a radically new perspective and allows us to address central questions in membrane and cell biology: How is the density of ER membrane proteins sensed and controlled? How are misfolded membrane proteins recognized to mount adaptive responses?

Focusing on the conceptual advance that UPR transducers sense signals from the membrane, we will 1) establish and reconstitute the machinery for sensing membrane protein crowding, 2) identify mechanisms coordinating protein and lipid homeostasis between organelles, 3) study the molecular recognition of misfolded membrane proteins by the UPR.

Key to this endeavor is our unique combination of genetic, biochemical, and biophysical tools for parallel characterization of the UPR in vivo and in vitro. Combining this framework with novel strategies for an immuno-isolation of organelles, we are primed to answer how membrane aberrancies cause chronic ER stress. By establishing the UPR as a quality control system for membrane proteins, and providing novel tools and valuable resources to the community, MemDense will have wide impact on our molecular and cellular understanding of ER homeostasis and the many diseases related to ER stress.

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The information about "MEMDENSE" are provided by the European Opendata Portal: CORDIS opendata.

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