Opendata, web and dolomites

AXONENDO SIGNED

Endosomal control of local protein synthesis in axons

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 AXONENDO project word cloud

Explore the words cloud of the AXONENDO project. It provides you a very rough idea of what is the project "AXONENDO" about.

physiology    signaling    coordinate    roles    compartmentalized    imaging    neurons    perturbing    foundations    trafficking    axonal    molecules    organelles    synthesis    selective    strategies    comprehension    endosomal    function    morphologically    integrate    revealed    unknown    xenopus    functionally    proteome    mediated    neuropathies    proteins    vertebrate    axonopathies    mrnas    novo    area    regulate    links    transfer    elucidating    possibility    endosomes    local    effect    ribosomes    vivo    regulation    dendrites    genetic    cellular    rely    fulfilling    gap    binding    therapeutic    relationship    rna    genome    axons    angle    mechanisms    techniques    protein    questions    ensures    combining    functions    functional    maintenance    tools    mouse    factors    motile    impaired    de    cells    mrna    translation    bridge    extracellular    route    endocytic    fundamental    endosome    neuronal    localization    modulate    complexes    plan    mediate    answering    associations    models   

Project "AXONENDO" data sheet

The following table provides information about the project.

Coordinator
OSPEDALE SAN RAFFAELE SRL 

Organization address
address: VIA OLGETTINA 60
city: MILANO
postcode: 20132
website: www.hsr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙499˙563 €
 EC max contribution 1˙499˙563 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OSPEDALE SAN RAFFAELE SRL IT (MILANO) coordinator 1˙499˙563.00

Map

 Project objective

Neurons are morphologically complex cells that rely on highly compartmentalized signaling to coordinate cellular functions. The endocytic pathway is a crucial trafficking route by which neurons integrate, spatially process and transfer information. Endosomal trafficking in axons and dendrites ensures that required molecules and signaling complexes are present where and when they are functionally needed thus fulfilling essential roles in neuronal physiology. Our recent work has revealed the presence of mRNAs and ribosomes on endosomes in axons, raising the exciting possibility that these motile organelles also directly modulate the local proteome by controlling de novo protein synthesis. However, the mechanisms by which endosomes regulate mRNA translation in neurons is unknown. Moreover, the roles of endosome-mediated control of protein synthesis in neuronal development and function have not been investigated. Here, we propose to bridge this knowledge gap by elucidating links between the endocytic pathway and local protein synthesis in neurons, focusing on their functional relationship in axons. By combining genome-wide analysis, genetic tools, state-of-the-art imaging techniques and the use of Xenopus and mouse vertebrate models, we plan to address the following fundamental questions: (i) What are the mRNAs associated with endosomes and does endosomal trafficking regulate their axonal localization? (ii) Does the endocytic pathway mediate the selective translation of axonal mRNAs in response to extracellular factors? (iii) What are the endosome-associated RNA-binding proteins, and what is the effect of perturbing these associations on axonal development and maintenance in vivo? (iv) Does impaired endosomal regulation of axonal mRNA localization and translation cause axonopathies? Answering these questions will set strong foundations for this new area of research and can provide a new angle in our comprehension of neuropathies in need of novel therapeutic strategies.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "AXONENDO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "AXONENDO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

HYPROTIN (2019)

Hyperpolarized Nuclear Magnetic Resonance Spectroscopy for Time-Resolved Monitoring of Interactions of Intrinsically Disordered Breast-Cancer Proteins

Read More  

ImmUne (2019)

Towards identification of the unifying principles of vertebrate adaptive immunity

Read More  

PSYDISC (2020)

Developing and Testing the Psychological Distance to Science Model

Read More