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AXONENDO SIGNED

Endosomal control of local protein synthesis in axons

Total Cost €

0

EC-Contrib. €

0

Partnership

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 AXONENDO project word cloud

Explore the words cloud of the AXONENDO project. It provides you a very rough idea of what is the project "AXONENDO" about.

localization    physiology    trafficking    combining    transfer    axonal    questions    techniques    gap    neurons    factors    molecules    fundamental    local    de    signaling    mediate    complexes    morphologically    proteins    answering    imaging    associations    protein    mrnas    elucidating    axons    genome    fulfilling    comprehension    mechanisms    rely    organelles    regulation    function    effect    xenopus    proteome    coordinate    perturbing    foundations    ribosomes    route    vertebrate    dendrites    endosome    possibility    vivo    genetic    strategies    roles    modulate    selective    neuropathies    endosomal    novo    rna    impaired    compartmentalized    synthesis    maintenance    extracellular    plan    regulate    endocytic    therapeutic    functional    cells    relationship    cellular    functions    ensures    endosomes    mediated    bridge    tools    area    axonopathies    angle    integrate    mouse    models    binding    unknown    neuronal    motile    translation    links    mrna    revealed    functionally   

Project "AXONENDO" data sheet

The following table provides information about the project.

Coordinator
OSPEDALE SAN RAFFAELE SRL 

Organization address
address: VIA OLGETTINA 60
city: MILANO
postcode: 20132
website: www.hsr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙499˙563 €
 EC max contribution 1˙499˙563 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OSPEDALE SAN RAFFAELE SRL IT (MILANO) coordinator 1˙499˙563.00

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 Project objective

Neurons are morphologically complex cells that rely on highly compartmentalized signaling to coordinate cellular functions. The endocytic pathway is a crucial trafficking route by which neurons integrate, spatially process and transfer information. Endosomal trafficking in axons and dendrites ensures that required molecules and signaling complexes are present where and when they are functionally needed thus fulfilling essential roles in neuronal physiology. Our recent work has revealed the presence of mRNAs and ribosomes on endosomes in axons, raising the exciting possibility that these motile organelles also directly modulate the local proteome by controlling de novo protein synthesis. However, the mechanisms by which endosomes regulate mRNA translation in neurons is unknown. Moreover, the roles of endosome-mediated control of protein synthesis in neuronal development and function have not been investigated. Here, we propose to bridge this knowledge gap by elucidating links between the endocytic pathway and local protein synthesis in neurons, focusing on their functional relationship in axons. By combining genome-wide analysis, genetic tools, state-of-the-art imaging techniques and the use of Xenopus and mouse vertebrate models, we plan to address the following fundamental questions: (i) What are the mRNAs associated with endosomes and does endosomal trafficking regulate their axonal localization? (ii) Does the endocytic pathway mediate the selective translation of axonal mRNAs in response to extracellular factors? (iii) What are the endosome-associated RNA-binding proteins, and what is the effect of perturbing these associations on axonal development and maintenance in vivo? (iv) Does impaired endosomal regulation of axonal mRNA localization and translation cause axonopathies? Answering these questions will set strong foundations for this new area of research and can provide a new angle in our comprehension of neuropathies in need of novel therapeutic strategies.

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The information about "AXONENDO" are provided by the European Opendata Portal: CORDIS opendata.

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