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AXONENDO SIGNED

Endosomal control of local protein synthesis in axons

Total Cost €

0

EC-Contrib. €

0

Partnership

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 AXONENDO project word cloud

Explore the words cloud of the AXONENDO project. It provides you a very rough idea of what is the project "AXONENDO" about.

genome    transfer    bridge    axonal    de    functionally    dendrites    mediate    answering    signaling    regulation    angle    therapeutic    effect    fulfilling    associations    endosome    regulate    physiology    neuronal    local    proteome    questions    factors    ensures    proteins    ribosomes    functional    relationship    mechanisms    foundations    elucidating    function    perturbing    impaired    integrate    mouse    genetic    translation    cellular    maintenance    techniques    axons    endosomes    mediated    localization    novo    gap    molecules    morphologically    neurons    area    fundamental    selective    links    neuropathies    organelles    rna    binding    cells    axonopathies    coordinate    plan    complexes    functions    revealed    possibility    vivo    combining    imaging    tools    protein    comprehension    roles    mrnas    rely    xenopus    endocytic    extracellular    strategies    unknown    models    motile    trafficking    endosomal    compartmentalized    synthesis    mrna    route    modulate    vertebrate   

Project "AXONENDO" data sheet

The following table provides information about the project.

Coordinator
OSPEDALE SAN RAFFAELE SRL 

Organization address
address: VIA OLGETTINA 60
city: MILANO
postcode: 20132
website: www.hsr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙499˙563 €
 EC max contribution 1˙499˙563 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OSPEDALE SAN RAFFAELE SRL IT (MILANO) coordinator 1˙499˙563.00

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 Project objective

Neurons are morphologically complex cells that rely on highly compartmentalized signaling to coordinate cellular functions. The endocytic pathway is a crucial trafficking route by which neurons integrate, spatially process and transfer information. Endosomal trafficking in axons and dendrites ensures that required molecules and signaling complexes are present where and when they are functionally needed thus fulfilling essential roles in neuronal physiology. Our recent work has revealed the presence of mRNAs and ribosomes on endosomes in axons, raising the exciting possibility that these motile organelles also directly modulate the local proteome by controlling de novo protein synthesis. However, the mechanisms by which endosomes regulate mRNA translation in neurons is unknown. Moreover, the roles of endosome-mediated control of protein synthesis in neuronal development and function have not been investigated. Here, we propose to bridge this knowledge gap by elucidating links between the endocytic pathway and local protein synthesis in neurons, focusing on their functional relationship in axons. By combining genome-wide analysis, genetic tools, state-of-the-art imaging techniques and the use of Xenopus and mouse vertebrate models, we plan to address the following fundamental questions: (i) What are the mRNAs associated with endosomes and does endosomal trafficking regulate their axonal localization? (ii) Does the endocytic pathway mediate the selective translation of axonal mRNAs in response to extracellular factors? (iii) What are the endosome-associated RNA-binding proteins, and what is the effect of perturbing these associations on axonal development and maintenance in vivo? (iv) Does impaired endosomal regulation of axonal mRNA localization and translation cause axonopathies? Answering these questions will set strong foundations for this new area of research and can provide a new angle in our comprehension of neuropathies in need of novel therapeutic strategies.

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The information about "AXONENDO" are provided by the European Opendata Portal: CORDIS opendata.

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