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AXONENDO SIGNED
Endosomal control of local protein synthesis in axons
Total Cost €
0EC-Contrib. €
0Partnership
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0AXONENDO project word cloud
Explore the words cloud of the AXONENDO project. It provides you a very rough idea of what is the project "AXONENDO" about.
functionally
signaling
localization
roles
dendrites
selective
compartmentalized
genetic
functional
de
perturbing
strategies
therapeutic
mediate
functions
function
axonopathies
neuropathies
axons
mrnas
rely
bridge
endosomes
endosome
molecules
integrate
synthesis
factors
techniques
xenopus
binding
axonal
transfer
endocytic
answering
tools
motile
complexes
translation
unknown
local
trafficking
foundations
angle
gap
cells
vertebrate
elucidating
proteins
neurons
morphologically
impaired
maintenance
coordinate
fundamental
modulate
mrna
proteome
imaging
combining
regulate
mechanisms
ribosomes
route
questions
cellular
fulfilling
organelles
models
relationship
possibility
comprehension
protein
associations
plan
mouse
neuronal
vivo
area
regulation
rna
revealed
genome
links
ensures
endosomal
novo
physiology
extracellular
mediated
effect
Project "AXONENDO" data sheet
The following table provides information about the project.
| Coordinator |
OSPEDALE SAN RAFFAELE SRL
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Total cost | 1˙499˙563 € |
| EC max contribution | 1˙499˙563 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2019-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-06-01 to 2025-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | OSPEDALE SAN RAFFAELE SRL | IT (MILANO) | coordinator | 1˙499˙563.00 |
Map
Project objective
Neurons are morphologically complex cells that rely on highly compartmentalized signaling to coordinate cellular functions. The endocytic pathway is a crucial trafficking route by which neurons integrate, spatially process and transfer information. Endosomal trafficking in axons and dendrites ensures that required molecules and signaling complexes are present where and when they are functionally needed thus fulfilling essential roles in neuronal physiology. Our recent work has revealed the presence of mRNAs and ribosomes on endosomes in axons, raising the exciting possibility that these motile organelles also directly modulate the local proteome by controlling de novo protein synthesis. However, the mechanisms by which endosomes regulate mRNA translation in neurons is unknown. Moreover, the roles of endosome-mediated control of protein synthesis in neuronal development and function have not been investigated. Here, we propose to bridge this knowledge gap by elucidating links between the endocytic pathway and local protein synthesis in neurons, focusing on their functional relationship in axons. By combining genome-wide analysis, genetic tools, state-of-the-art imaging techniques and the use of Xenopus and mouse vertebrate models, we plan to address the following fundamental questions: (i) What are the mRNAs associated with endosomes and does endosomal trafficking regulate their axonal localization? (ii) Does the endocytic pathway mediate the selective translation of axonal mRNAs in response to extracellular factors? (iii) What are the endosome-associated RNA-binding proteins, and what is the effect of perturbing these associations on axonal development and maintenance in vivo? (iv) Does impaired endosomal regulation of axonal mRNA localization and translation cause axonopathies? Answering these questions will set strong foundations for this new area of research and can provide a new angle in our comprehension of neuropathies in need of novel therapeutic strategies.
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The information about "AXONENDO" are provided by the European Opendata Portal: CORDIS opendata.
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No valid XML
lastchecktime (2024-07-27 2:17:38) correctly updated