Opendata, web and dolomites
inhibiTOR SIGNED
Novel selective mTORC1 inhibitors
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0inhibiTOR project word cloud
Explore the words cloud of the inhibiTOR project. It provides you a very rough idea of what is the project "inhibiTOR" about.
few
efficient
safer
hepatocellular
effectiveness
mechanism
hyperglycemia
assay
inhibition
deaths
drug
multikinase
clinical
suggests
chronically
proof
primary
correlates
inhibit
fourth
enhances
4e
predominant
pharmacological
clinic
months
fail
efficacy
mammalian
mtorc1
safety
inhibiting
cancers
hyperlipidemia
survival
worldwide
form
effect
undesirable
alone
rapamycin
potentially
completely
administered
predict
unrelated
conferring
applicability
upregulation
selective
treat
grant
carcinoma
biophysical
options
synergy
context
insulin
rapalogs
bp
therapy
rapalog
little
hcc
resistance
combination
central
cancer
signaling
action
mtorc2
sorafenib
inhibitors
phosphorylation
treatment
approved
liver
revealed
erc
inhibitor
derivatives
limited
Project "inhibiTOR" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITAT BASEL
Organization address contact info |
| Coordinator Country | Switzerland [CH] |
| Total cost | 0 € |
| EC max contribution | 150˙000 € (0%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2019-PoC |
| Funding Scheme | ERC-POC-LS |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-01-01 to 2021-06-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITAT BASEL | CH (BASEL) | coordinator | 150˙000.00 |
Map
Project objective
Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and the fourth leading cause of cancer-related deaths worldwide. The multikinase inhibitor sorafenib is the only approved drug to treat HCC and on average enhances survival by three months. Thus, the efficacy of current HCC treatment options is very limited. Studies in the context of our ERC-Synergy grant revealed that sorafenib resistance correlates with upregulation of mammalian target of rapamycin complex 1 (mTORC1) signaling. The central role of mTORC1 in conferring therapy resistance suggests that effective therapy against HCC may require combination of a primary inhibitor (e.g., sorafenib) and an mTORC1 inhibitor. The mTORC1 inhibitor rapamycin and its derivatives (rapalogs) are approved for a few advanced cancers, but not for HCC. Their clinical applicability is limited by their effectiveness and safety. Rapalogs fail to completely inhibit mTORC1 as they have little effect on inhibiting phosphorylation of 4E-BP, one of the two main targets of mTORC1. Moreover, rapamycin and rapalogs also inhibit mTORC2 when chronically administered, leading to undesirable effects such as hyperglycemia, hyperlipidemia, and insulin resistance. We have established a biophysical assay to identify selective mTORC1 inhibitors with a novel, rapalog-unrelated, mechanism of action. We predict these inhibitors to be more selective, more effective, and potentially safer than mTORC1 inhibitors currently used in the clinic. In this Proof of Concept project, we aim to study the pharmacological potential of selective and efficient mTORC1 inhibition alone or in combination therapy with sorafenib to treat HCC.
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The information about "INHIBITOR" are provided by the European Opendata Portal: CORDIS opendata.
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No valid XML
lastchecktime (2024-09-20 8:25:31) correctly updated