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NOSCAR SIGNED

decipheriNg Oncogenic SIgnalling patterns to break CAncer drug Resistance

Total Cost €

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EC-Contrib. €

0

Partnership

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 NOSCAR project word cloud

Explore the words cloud of the NOSCAR project. It provides you a very rough idea of what is the project "NOSCAR" about.

perturbations    spheroid    components    organoids    explore    successfully    genetic    delineate    avenues    significantly    vulnerabilities    cultures    training    drug    fellowship    career    decisions    self    reports    ecosystem    fourth    computer    network    resistance    patients    cellular    dynamics    clinically    cells    ras    cure    compendium    tumor    receive    latter    erk    fate    statistical    aggressive    therapy    modern    multiplexed    patterns    promise    organizing    pi3k    patient    oncogenic    limit    compromised    cancer    structures    restart    perturbed    prospects    mutation    single    breast    insights    confer    mentoring    survive    noscar    despite    framework    signalling    vision    progress    thanks    atlas    treat    locally    benefit    3d    quantitative    therapies    disease    dynamic    signaling    combines    akt    mutations    rewired    biosensor    heterogeneity    biology    cell    robustness    combinations    mechanisms    treatment    drugs    academic   

Project "NOSCAR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 304˙724 €
 EC max contribution 304˙724 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 304˙724.00

Map

 Project objective

Despite significant progress in drug therapies for breast cancer, about one fourth of patients still do not survive the disease. Modern, targeted therapies have been proposed to cure the more advanced and aggressive cases of breast cancer. However, non-genetic and genetic mechanisms of drug resistance currently limit the promise of targeted therapy. NOSCAR aims to define the oncogenic Ras/Erk and PI3K/Akt signalling states relevant to breast cancer oncogenic mutations, and delineate the mechanisms which enable development of cancer resistance to targeted therapies. NOSCAR’s objectives are: Using a quantitative cell biology framework that combines a multiplexed biosensor system that reports on Erk/Akt dynamics at single cell level, computer vision, and statistical modelling, I will: (1) produce an atlas of single-cell Erk/Akt dynamic signalling patterns that are associated with a compendium of clinically-relevant breast cancer mutations; (2) measure the signalling states in cells perturbed with clinically-relevant drugs that target different components of the Ras/Erk and PI3K/Akt pathways to evaluate how the oncogenic signalling network is rewired by drug treatment; (3) measure signalling dynamics in 3D spheroid cultures and patient-derived organoids to explore how a self-organizing cellular ecosystem can spatially control signalling at the single cell level to locally control fate decisions, and how the latter process is compromised by an oncogenic mutation. This will provide new insights about tumor heterogeneity and signaling network structures that confer robustness against drug perturbations. We expect to identify vulnerabilities that might be efficiently targeted by drug combinations, providing new avenues to treat breast cancer. The planned research together with training and mentoring that I will receive thanks to the fellowship, will enable to successfully restart my career in research and will significantly benefit my further academic career prospects.

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The information about "NOSCAR" are provided by the European Opendata Portal: CORDIS opendata.

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