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NOSCAR SIGNED

decipheriNg Oncogenic SIgnalling patterns to break CAncer drug Resistance

Total Cost €

0

EC-Contrib. €

0

Partnership

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 NOSCAR project word cloud

Explore the words cloud of the NOSCAR project. It provides you a very rough idea of what is the project "NOSCAR" about.

tumor    robustness    latter    patterns    compendium    vulnerabilities    cell    combines    avenues    statistical    restart    cultures    fate    reports    ecosystem    breast    fellowship    biology    components    therapy    oncogenic    disease    framework    computer    single    benefit    organoids    combinations    mutation    signalling    delineate    prospects    3d    drugs    atlas    genetic    confer    training    treat    structures    despite    progress    explore    receive    significantly    ras    vision    successfully    perturbations    fourth    aggressive    spheroid    cure    quantitative    therapies    career    locally    multiplexed    akt    drug    mutations    biosensor    erk    cancer    limit    perturbed    self    dynamic    academic    insights    thanks    compromised    mentoring    organizing    dynamics    clinically    rewired    heterogeneity    resistance    network    promise    patients    mechanisms    cells    survive    pi3k    noscar    cellular    signaling    treatment    patient    decisions    modern   

Project "NOSCAR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 304˙724 €
 EC max contribution 304˙724 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 304˙724.00

Map

 Project objective

Despite significant progress in drug therapies for breast cancer, about one fourth of patients still do not survive the disease. Modern, targeted therapies have been proposed to cure the more advanced and aggressive cases of breast cancer. However, non-genetic and genetic mechanisms of drug resistance currently limit the promise of targeted therapy. NOSCAR aims to define the oncogenic Ras/Erk and PI3K/Akt signalling states relevant to breast cancer oncogenic mutations, and delineate the mechanisms which enable development of cancer resistance to targeted therapies. NOSCAR’s objectives are: Using a quantitative cell biology framework that combines a multiplexed biosensor system that reports on Erk/Akt dynamics at single cell level, computer vision, and statistical modelling, I will: (1) produce an atlas of single-cell Erk/Akt dynamic signalling patterns that are associated with a compendium of clinically-relevant breast cancer mutations; (2) measure the signalling states in cells perturbed with clinically-relevant drugs that target different components of the Ras/Erk and PI3K/Akt pathways to evaluate how the oncogenic signalling network is rewired by drug treatment; (3) measure signalling dynamics in 3D spheroid cultures and patient-derived organoids to explore how a self-organizing cellular ecosystem can spatially control signalling at the single cell level to locally control fate decisions, and how the latter process is compromised by an oncogenic mutation. This will provide new insights about tumor heterogeneity and signaling network structures that confer robustness against drug perturbations. We expect to identify vulnerabilities that might be efficiently targeted by drug combinations, providing new avenues to treat breast cancer. The planned research together with training and mentoring that I will receive thanks to the fellowship, will enable to successfully restart my career in research and will significantly benefit my further academic career prospects.

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The information about "NOSCAR" are provided by the European Opendata Portal: CORDIS opendata.

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