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M6AQuantKit SIGNED

Development and commercialization of kit for quantitative interrogation of a key RNA modification

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 M6AQuantKit project word cloud

Explore the words cloud of the M6AQuantKit project. It provides you a very rough idea of what is the project "M6AQuantKit" about.

immense    therapeutic    pharma    benefit    levels    business    strategy    commercialization    self    quantitative    multiplexed    renewal    plays    therapeutics    hepatocellular    dysregulation    cancer    mazter    tool    industry    position    ip    variety    raised    academic    interrogation    fundamental    community    poc    implicated    methyladenosine    patient    seeking    streamlined    amenable    roles    systematic    functions    leukemia    startup    diagnostic    drug    methodology    commercializable    market    metabolism    consequently    simultaneous    biotech    methylation    feedback    input    readout    monitoring    rna    labs    seq    interrogating    quantifying    human    prioritizing    rnase    industries    considerations    m6a    machinery    n6    sensitive    first    kit    amounts    cell    consistently    vast    added    exhibits    diseases    cancers    multiple    unravelling    planning    protocol    samples    erc    data    relying    disease    create    profiling    coupled    carcinoma    representing    actions    material    unmet    harnesses    metastasis    stem    ribonuclease    scientific    regulation    glioblastoma   

Project "M6AQuantKit" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 150˙000.00

Map

 Project objective

N6-Methyladenosine (m6A) plays fundamental roles in regulation of metabolism, stem cell self-renewal, and metastasis. Consistently its dysregulation is implicated in a variety of human cancers including leukemia, glioblastoma and hepatocellular carcinoma. Consequently, the potential of m6A both as a novel cancer diagnostic and as a drug target has raised immense interest in scientific community and industry. For unravelling m6A functions, for the development of therapeutics and for prioritizing diseases and disease states most likely to benefit from therapeutic targeting of the methylation complex, it is thus of crucial importance to be able to measure the levels at which m6A is present. In our ERC project we addressed this challenge and developed MAZTER-seq, a methodology for quantifying m6A levels relying on a methylation-sensitive ribonuclease (RNase), representing the first systematic approach for quantitative interrogating of m6A levels.

The goal of the project is to advance our approach as commercializable kit for quantitative profiling of m6A. In the PoC, we will develop multiplexed protocol of MAZTER-seq that allows the simultaneous processing and interrogation of multiple samples from low amounts of sample material. The kit, coupled with streamlined data analysis tool, addresses a major market need and exhibits significant added value for academic labs and the biotech & pharma industries targeting the methylation machinery, e.g. for creating novel RNA based therapeutics. Our readout from low-input material makes m6A monitoring amenable to patient samples, representing an unmet challenge across all our target market. Thus, our goal is to create a startup which harnesses the vast market potential. In the PoC, the commercialization considerations are advanced through actions such as, seeking market feedback, strengthening the IP position, defining the business strategy and planning business execution.

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The information about "M6AQUANTKIT" are provided by the European Opendata Portal: CORDIS opendata.

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