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Trep-AB SIGNED

Repurposing clinically approved antibacterial drugs for treponematoses therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Trep-AB project word cloud

Explore the words cloud of the Trep-AB project. It provides you a very rough idea of what is the project "Trep-AB" about.

rabbits    advantage    events    regimens    burden    mutations    azithromycin    spirochetes    randomized    infection    susceptibility    shortage    resistant    strains    allergy    confirmed    penicillin    drug    efficacy    basis    cns    incorporate    bacteria    candidates    efficacious    conducting    stages    team    antibiotic    human    similarity    penetration    combination    experimentally    treponemal    options    prediction    tremendous    nervous    drugs    standard    macrolide    resource    microorganism    shows    therapeutic    pallidum    central    cure    disseminate    syphilis    clarify    unknown    validated    acquire    clinical    restricted    broadly    good    current    recurrent    treatment    speaking    risk    lactams    profile    reduce    expertise    prioritized    jeopardize    injectable    resistance    candidate    yaws    treponema    antibiotics    computational    culture    trials    treponematoses    confer    lesion    campaign    antibacterial    investigational    patients    eradication    survive    biological    infected    oral    global    grown    preliminary   

Project "Trep-AB" data sheet

The following table provides information about the project.

Coordinator
FUNDACION PRIVADA DE LUCHA CONTRA EL SIDA 

Organization address
address: CARRETERA DE CANYET HOSPITAL GERMANS TRIAS I PUJOL PLANTA 2
city: BADALONA
postcode: 8916
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙498˙790 €
 EC max contribution 1˙498˙790 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2025-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION PRIVADA DE LUCHA CONTRA EL SIDA ES (BADALONA) coordinator 1˙150˙678.00
2    UNIVERSITY OF WASHINGTON US (SEATTLE WA) participant 348˙111.00

Map

 Project objective

Current therapeutic options for human treponematoses, syphilis and yaws, are, broadly speaking, restricted to one antibiotic: injectable penicillin. The drug susceptibility profile of Treponema pallidum (T.p) is unknown because the microorganism could not be grown in culture. Treatment failure after penicillin has been related to syphilis bacteria that survive in the central nervous system (CNS) and the potential of strains to acquire resistance to penicillin has recently been recognized. Yaws can be treated with azithromycin but there is a real risk that macrolide-resistant strains disseminate widely and jeopardize the global eradication campaign. I propose a research program to have other validated treatment options with good CNS penetration that are efficacious for all the stages of treponemal infection. Our preliminary results using computational prediction of drug activity based on similarity to drugs with known activity against T.p. and other spirochetes shows several candidate antibiotics. I will take advantage of recent developments in culture methods for determination of drug susceptibility to test 20 prioritized drugs. These results will be confirmed in experimentally infected rabbits treated with the investigational drugs and assessed for lesion development and T.p. burden. My second approach will exploit the established expertise of my team conducting randomized clinical trials to evaluate the efficacy of the 2 most promising candidates compared to standard treatment to cure patients with syphilis/yaws. Such studies will incorporate in-depth studies of recurrent events among study participants, to further clarify the biological basis and identify mutations that confer resistance to B-lactams. New antibacterial oral drugs for the treatment of treponematoses will be a tremendous resource in case of penicillin treatment-failure, resistance, shortage, allergy, or for use in yaws combination regimens to reduce the likelihood of resistance selection.

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The information about "TREP-AB" are provided by the European Opendata Portal: CORDIS opendata.

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