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Trep-AB SIGNED

Repurposing clinically approved antibacterial drugs for treponematoses therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Trep-AB project word cloud

Explore the words cloud of the Trep-AB project. It provides you a very rough idea of what is the project "Trep-AB" about.

antibiotics    resistance    burden    risk    treponema    central    acquire    advantage    resource    experimentally    lactams    speaking    options    efficacy    susceptibility    infection    candidate    computational    yaws    team    bacteria    strains    confer    good    incorporate    drug    jeopardize    regimens    preliminary    human    lesion    treponematoses    macrolide    investigational    antibiotic    pallidum    recurrent    survive    global    therapeutic    antibacterial    cns    penicillin    disseminate    campaign    nervous    basis    reduce    drugs    resistant    biological    efficacious    prediction    culture    eradication    validated    treatment    spirochetes    penetration    clinical    shows    clarify    patients    conducting    restricted    infected    standard    profile    microorganism    azithromycin    treponemal    prioritized    broadly    events    candidates    similarity    shortage    confirmed    grown    stages    combination    syphilis    unknown    rabbits    cure    trials    injectable    oral    allergy    randomized    mutations    tremendous    expertise    current   

Project "Trep-AB" data sheet

The following table provides information about the project.

Coordinator
FUNDACION PRIVADA DE LUCHA CONTRA EL SIDA 

Organization address
address: CARRETERA DE CANYET HOSPITAL GERMANS TRIAS I PUJOL PLANTA 2
city: BADALONA
postcode: 8916
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙498˙790 €
 EC max contribution 1˙498˙790 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2025-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION PRIVADA DE LUCHA CONTRA EL SIDA ES (BADALONA) coordinator 1˙150˙678.00
2    UNIVERSITY OF WASHINGTON US (SEATTLE WA) participant 348˙111.00

Map

 Project objective

Current therapeutic options for human treponematoses, syphilis and yaws, are, broadly speaking, restricted to one antibiotic: injectable penicillin. The drug susceptibility profile of Treponema pallidum (T.p) is unknown because the microorganism could not be grown in culture. Treatment failure after penicillin has been related to syphilis bacteria that survive in the central nervous system (CNS) and the potential of strains to acquire resistance to penicillin has recently been recognized. Yaws can be treated with azithromycin but there is a real risk that macrolide-resistant strains disseminate widely and jeopardize the global eradication campaign. I propose a research program to have other validated treatment options with good CNS penetration that are efficacious for all the stages of treponemal infection. Our preliminary results using computational prediction of drug activity based on similarity to drugs with known activity against T.p. and other spirochetes shows several candidate antibiotics. I will take advantage of recent developments in culture methods for determination of drug susceptibility to test 20 prioritized drugs. These results will be confirmed in experimentally infected rabbits treated with the investigational drugs and assessed for lesion development and T.p. burden. My second approach will exploit the established expertise of my team conducting randomized clinical trials to evaluate the efficacy of the 2 most promising candidates compared to standard treatment to cure patients with syphilis/yaws. Such studies will incorporate in-depth studies of recurrent events among study participants, to further clarify the biological basis and identify mutations that confer resistance to B-lactams. New antibacterial oral drugs for the treatment of treponematoses will be a tremendous resource in case of penicillin treatment-failure, resistance, shortage, allergy, or for use in yaws combination regimens to reduce the likelihood of resistance selection.

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The information about "TREP-AB" are provided by the European Opendata Portal: CORDIS opendata.

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