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ALTER-brain SIGNED

Metastasis-associated altered molecular patterns in the brain

Total Cost €

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EC-Contrib. €

0

Partnership

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 ALTER-brain project word cloud

Explore the words cloud of the ALTER-brain project. It provides you a very rough idea of what is the project "ALTER-brain" about.

initiating    understand    slowly    validate    clinically    treat    diagnosis    cells    tracing    connected    pressure    mice    relies    rising    lesions    clinical    na    treating    translated    functional    cancer    underlying    inefficient    unknown    organ    origin    metastatic    pro    once    therapeutic    rates    mouse    options    tumour    iuml    patterns    survival    emerge    heterogeneity    altered    brain    engineered    dissecting    metastasis    principles    networks    components    colonization    relevance    combined    microenvironment    limiting    genetically    incidence    previously    network    alter    experimental    cell    ve    lineage    reprogrammed    prevalent    pathological    metastases    rewired    models    simultaneously    re    basis    therapy    initiate    spontaneous    types    relapse    few    initial    critical    human    ways    nurture    technologies    reprogramming    poor    innovative    actively    newly    prevent    favouring    outgrowth    molecular    explore    identification    biology    ecosystem    disorders   

Project "ALTER-brain" data sheet

The following table provides information about the project.

Coordinator
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III 

Organization address
address: CALLE MELCHOR FERNANDEZ ALMAGRO 3
city: MADRID
postcode: 28029
website: www.cnio.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙897˙437 €
 EC max contribution 1˙897˙437 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2025-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III ES (MADRID) coordinator 1˙897˙437.00

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 Project objective

Organ colonization is the most inefficient step of metastasis. However, once a few cancer cells manage to re-initiate their growth in the brain, the initial naïve microenvironment, which was not favouring and even actively limiting the number of potential metastasis initiating cells, is slowly rewired into a different ecosystem with pro-metastatic properties. In this project (ALTER-brain), we will study the biology of microenvironment reprogramming to explore innovative ways of treating metastasis. Microenvironment reprogramming relies on altered molecular patterns that emerge in specific brain cell types simultaneously to the outgrowth of metastases. Dissecting the biology of these emerging patterns and their functional consequences could provide the basis to prevent metastasis but also to treat advances lesions. A key objective of ALTER-brain is the identification of newly established functional networks among previously non-connected components of the microenvironment that are critical to nurture tumour growth. This research proposal focuses on metastasis in the brain given its rising incidence, poor therapeutic options and short survival rates upon diagnosis. ALTER-brain will use novel (i.e. spontaneous metastasis) and clinically relevant (i.e. relapse after therapy) experimental mouse models of brain metastasis combined with genetically engineered mice in which we will target specific components of the microenvironment. In addition, we will apply novel lineage tracing technologies to understand the origin and emerging heterogeneity of the reprogrammed microenvironment. Given the clinical relevance of our research, human brain metastasis provided by our clinical network will be used to validate key findings. ALTER-brain will identify key principles underlying the unknown biology of the brain under a specific pathological pressure that might be translated to other highly prevalent disorders affecting this organ in the future.

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The information about "ALTER-BRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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