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RECYPION SIGNED

Resurrecting the Carboxyl Polyether Ionophores

Total Cost €

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EC-Contrib. €

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Partnership

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 RECYPION project word cloud

Explore the words cloud of the RECYPION project. It provides you a very rough idea of what is the project "RECYPION" about.

ion    microbial    150    molecular    obscure    biological    space    questions    recypion    fundamental    harbor    stagger    activities    components    transformations    morphological    cpis    total    ultrafast    extremely    polyether    cellular    first    thought    pioneer    gt    world    team    uncover    members    draw    spotlight    unprecedented    uninteresting    metabolites    paradigm    spectroscopy    nature    profiling    antibiotic    class    mechanism    post    canonical    era    cells    preserve    interesting    structural    chemical    agents    dark    position    natural    experimental    reveal    relate    involve    membrane    gradients    surface    expand    nmr    membranes    back    cpi    secondary    completely    synthesis    function    sensitive    complicated    compounds    image    darlings    carboxyl    ultra    significantly    resident    anti    recycle    belonging    equilibrating    respect    ask    largely    determinants    mediate    perhaps    screening    deconstruct    characterization    ionophores    unspecific    abundant    family    advocate    molecules    transport    explore    opposite   

Project "RECYPION" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙998˙864 €
 EC max contribution 1˙998˙864 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 1˙998˙864.00

Map

 Project objective

The carboxyl polyether ionophores (CPIs) is a class of >150 complex natural products. Belonging to the most complicated of Nature's secondary metabolites, they are darlings within total chemical synthesis, however, the biological role of these agents is obscure. Due to their canonical function of equilibrating ion-gradients across biological membranes, CPIs are thought to be unspecific and largely uninteresting. Here, I will advocate and demonstrate the opposite position: that not only are these compounds extremely interesting with respect to their complex effects on cells, they also harbor a unique anti-microbial activity that should be a strong priority as we stagger towards a post-antibiotic era. With RECYPION my team and I will draw these compounds back into the spotlight. We will ask the following fundamental questions: 1. Can we develop a synthesis-paradigm that will significantly expand the CPI-chemical space to fully explore their anti-microbial activities? 2. What are the molecular determinants that control the antibiotic-potential of the CPIs, and how do these relate to the mechanism of ion-transport? 3. Can we uncover the cellular activities of CPIs – perhaps even “dark” activities that do not involve ion-transport? We will pioneer a CPI-synthesis-approach based on the ability to recycle complex components from highly abundant CPI-family members. To do so, we will develop novel chemical transformations to deconstruct these molecules which may find broader use in a world that is increasingly focused on how to preserve resources. We will provide the first real experimental characterization of the molecular mechanism by which CPIs mediate ion transport by using ultrafast surface-sensitive spectroscopy on membrane-resident CPIs along with unprecedented structural insight using ultra-high field NMR. Finally, we will use an image-based screening technology called morphological profiling to reveal completely new cellular activities of the CPIs.

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The information about "RECYPION" are provided by the European Opendata Portal: CORDIS opendata.

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