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RECYPION SIGNED

Resurrecting the Carboxyl Polyether Ionophores

Total Cost €

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EC-Contrib. €

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Partnership

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 RECYPION project word cloud

Explore the words cloud of the RECYPION project. It provides you a very rough idea of what is the project "RECYPION" about.

experimental    recypion    class    equilibrating    determinants    fundamental    dark    cpi    paradigm    nature    perhaps    nmr    team    respect    image    molecules    transport    profiling    largely    synthesis    cells    extremely    gt    structural    completely    significantly    cellular    members    era    secondary    anti    ultrafast    mediate    uninteresting    explore    membranes    position    natural    darlings    canonical    morphological    metabolites    abundant    membrane    molecular    complicated    belonging    advocate    components    resident    space    biological    unprecedented    activities    antibiotic    interesting    deconstruct    compounds    cpis    chemical    harbor    questions    ask    ultra    unspecific    150    expand    mechanism    polyether    agents    surface    carboxyl    spotlight    pioneer    screening    world    spectroscopy    total    function    preserve    gradients    microbial    recycle    post    characterization    involve    reveal    draw    back    family    first    relate    stagger    thought    obscure    sensitive    transformations    opposite    uncover    ion    ionophores   

Project "RECYPION" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙998˙864 €
 EC max contribution 1˙998˙864 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 1˙998˙864.00

Map

 Project objective

The carboxyl polyether ionophores (CPIs) is a class of >150 complex natural products. Belonging to the most complicated of Nature's secondary metabolites, they are darlings within total chemical synthesis, however, the biological role of these agents is obscure. Due to their canonical function of equilibrating ion-gradients across biological membranes, CPIs are thought to be unspecific and largely uninteresting. Here, I will advocate and demonstrate the opposite position: that not only are these compounds extremely interesting with respect to their complex effects on cells, they also harbor a unique anti-microbial activity that should be a strong priority as we stagger towards a post-antibiotic era. With RECYPION my team and I will draw these compounds back into the spotlight. We will ask the following fundamental questions: 1. Can we develop a synthesis-paradigm that will significantly expand the CPI-chemical space to fully explore their anti-microbial activities? 2. What are the molecular determinants that control the antibiotic-potential of the CPIs, and how do these relate to the mechanism of ion-transport? 3. Can we uncover the cellular activities of CPIs – perhaps even “dark” activities that do not involve ion-transport? We will pioneer a CPI-synthesis-approach based on the ability to recycle complex components from highly abundant CPI-family members. To do so, we will develop novel chemical transformations to deconstruct these molecules which may find broader use in a world that is increasingly focused on how to preserve resources. We will provide the first real experimental characterization of the molecular mechanism by which CPIs mediate ion transport by using ultrafast surface-sensitive spectroscopy on membrane-resident CPIs along with unprecedented structural insight using ultra-high field NMR. Finally, we will use an image-based screening technology called morphological profiling to reveal completely new cellular activities of the CPIs.

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The information about "RECYPION" are provided by the European Opendata Portal: CORDIS opendata.

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