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RECYPION SIGNED

Resurrecting the Carboxyl Polyether Ionophores

Total Cost €

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EC-Contrib. €

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Partnership

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 RECYPION project word cloud

Explore the words cloud of the RECYPION project. It provides you a very rough idea of what is the project "RECYPION" about.

characterization    ultrafast    determinants    cells    darlings    deconstruct    carboxyl    morphological    questions    screening    involve    era    membranes    class    spectroscopy    anti    activities    transformations    advocate    transport    unprecedented    mediate    natural    team    back    respect    150    gradients    thought    secondary    total    obscure    polyether    ion    canonical    abundant    mechanism    expand    space    experimental    complicated    recypion    stagger    metabolites    recycle    nature    gt    world    post    extremely    structural    first    pioneer    biological    function    resident    nmr    completely    ionophores    draw    dark    explore    uncover    agents    surface    synthesis    antibiotic    microbial    membrane    cellular    spotlight    perhaps    reveal    image    components    molecules    largely    ask    relate    position    preserve    significantly    members    molecular    cpi    opposite    sensitive    equilibrating    interesting    cpis    compounds    unspecific    paradigm    belonging    chemical    uninteresting    family    profiling    fundamental    harbor    ultra   

Project "RECYPION" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙998˙864 €
 EC max contribution 1˙998˙864 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 1˙998˙864.00

Map

 Project objective

The carboxyl polyether ionophores (CPIs) is a class of >150 complex natural products. Belonging to the most complicated of Nature's secondary metabolites, they are darlings within total chemical synthesis, however, the biological role of these agents is obscure. Due to their canonical function of equilibrating ion-gradients across biological membranes, CPIs are thought to be unspecific and largely uninteresting. Here, I will advocate and demonstrate the opposite position: that not only are these compounds extremely interesting with respect to their complex effects on cells, they also harbor a unique anti-microbial activity that should be a strong priority as we stagger towards a post-antibiotic era. With RECYPION my team and I will draw these compounds back into the spotlight. We will ask the following fundamental questions: 1. Can we develop a synthesis-paradigm that will significantly expand the CPI-chemical space to fully explore their anti-microbial activities? 2. What are the molecular determinants that control the antibiotic-potential of the CPIs, and how do these relate to the mechanism of ion-transport? 3. Can we uncover the cellular activities of CPIs – perhaps even “dark” activities that do not involve ion-transport? We will pioneer a CPI-synthesis-approach based on the ability to recycle complex components from highly abundant CPI-family members. To do so, we will develop novel chemical transformations to deconstruct these molecules which may find broader use in a world that is increasingly focused on how to preserve resources. We will provide the first real experimental characterization of the molecular mechanism by which CPIs mediate ion transport by using ultrafast surface-sensitive spectroscopy on membrane-resident CPIs along with unprecedented structural insight using ultra-high field NMR. Finally, we will use an image-based screening technology called morphological profiling to reveal completely new cellular activities of the CPIs.

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The information about "RECYPION" are provided by the European Opendata Portal: CORDIS opendata.

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