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SICNET SIGNED

Statistical Inference of the Cerebellar Network

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SICNET project word cloud

Explore the words cloud of the SICNET project. It provides you a very rough idea of what is the project "SICNET" about.

technological    connectivity    temporal    cellular    cerebellar    cortical    mechanisms    believe    theoretical    optimization    cell    representations    tuning    capacity    little    synaptic    milliseconds    calcium    patterns    led    arising    precise    imaging    brain    elucidate    conditioning    neuroscience    network    substrate    neuronal    examine    comparatively    sensory    time    anatomical    circuits    fine    statistical    despite    actions    accuracy    thereby    physiological    fundamental    recordings    sequential    break    question    types    temporally    neural    cerebellum    models    sequences    behaviors    resolution    generative    carlo    theory    experimental    functional    laboratory    rigorous    organization    perfect    effort    direct    host    model    combination    constraints    dependent    revealed    monte    behaving    synapse    computation    understand    circuit    learning    dynamic    driving    data    coordinate    plays    match    infer    computations    animals    drive    barriers    behavior    extract    hypothesis    insights    evolutionary   

Project "SICNET" data sheet

The following table provides information about the project.

Coordinator
INSTITUT PASTEUR 

Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724
website: http://www.pasteur.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 196˙707.00

Map

 Project objective

The brain can coordinate complex sequences of actions with the accuracy of milliseconds. Where and how these neural computations occur is an open question in neuroscience. Despite recent technological developments allowing for large-scale high-resolution functional imaging of the brain and direct neuronal recordings in behaving animals, there has been little effort in applying rigorous statistical approaches to test circuit connectivity patterns and synaptic mechanisms driving neural activity.

Experimental evidence from classical conditioning and neuronal recordings have revealed that the cerebellum plays a fundamental role in fine-tuning of temporally precise behaviors. This project aims to elucidate the neural computation arising from anatomical and physiological constraints of the comparatively simple organization of the cerebellar cortical circuit, which allows the cerebellum to represent time-dependent sensory information necessary to drive behavior. Experimental and theoretical findings in the host laboratory have led to the hypothesis that dynamic synapse are a substrate for temporal representations and temporal learning. I will use sequential Monte Carlo methods to extract activity from calcium imaging data. Then I will use a generative model of the cerebellar network to infer the connectivity among the known cell types of the cerebellum as well as their synaptic properties. Finally, I will use information theory to examine the processing capacity of the cerebellar network, thereby providing new insights on evolutionary optimization of brain computation.

The combination of my experience in statistical methods and the host laboratory's experience in state-of-art neural recordings and theoretical models, is a perfect match to break down the barriers to understanding the cellular mechanisms of circuit computations. We believe that this analysis approach could also be applied to understand other neuronal circuits.

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The information about "SICNET" are provided by the European Opendata Portal: CORDIS opendata.

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