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Statistical Inference of the Cerebellar Network

Total Cost €


EC-Contrib. €






 SICNET project word cloud

Explore the words cloud of the SICNET project. It provides you a very rough idea of what is the project "SICNET" about.

experimental    believe    hypothesis    temporally    theory    match    actions    sensory    optimization    break    models    fundamental    precise    anatomical    theoretical    revealed    constraints    organization    coordinate    time    model    plays    comparatively    combination    carlo    infer    laboratory    neuronal    elucidate    temporal    types    connectivity    mechanisms    milliseconds    driving    network    imaging    rigorous    effort    direct    capacity    extract    technological    cell    little    dynamic    physiological    data    barriers    behaving    conditioning    circuit    neuroscience    cortical    statistical    computations    cerebellar    substrate    generative    synapse    calcium    monte    recordings    evolutionary    animals    dependent    host    neural    perfect    thereby    despite    cerebellum    circuits    tuning    sequential    drive    functional    patterns    cellular    led    representations    insights    resolution    brain    question    examine    arising    sequences    fine    accuracy    behavior    understand    synaptic    learning    computation    behaviors   

Project "SICNET" data sheet

The following table provides information about the project.


Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 196˙707.00


 Project objective

The brain can coordinate complex sequences of actions with the accuracy of milliseconds. Where and how these neural computations occur is an open question in neuroscience. Despite recent technological developments allowing for large-scale high-resolution functional imaging of the brain and direct neuronal recordings in behaving animals, there has been little effort in applying rigorous statistical approaches to test circuit connectivity patterns and synaptic mechanisms driving neural activity.

Experimental evidence from classical conditioning and neuronal recordings have revealed that the cerebellum plays a fundamental role in fine-tuning of temporally precise behaviors. This project aims to elucidate the neural computation arising from anatomical and physiological constraints of the comparatively simple organization of the cerebellar cortical circuit, which allows the cerebellum to represent time-dependent sensory information necessary to drive behavior. Experimental and theoretical findings in the host laboratory have led to the hypothesis that dynamic synapse are a substrate for temporal representations and temporal learning. I will use sequential Monte Carlo methods to extract activity from calcium imaging data. Then I will use a generative model of the cerebellar network to infer the connectivity among the known cell types of the cerebellum as well as their synaptic properties. Finally, I will use information theory to examine the processing capacity of the cerebellar network, thereby providing new insights on evolutionary optimization of brain computation.

The combination of my experience in statistical methods and the host laboratory's experience in state-of-art neural recordings and theoretical models, is a perfect match to break down the barriers to understanding the cellular mechanisms of circuit computations. We believe that this analysis approach could also be applied to understand other neuronal circuits.

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The information about "SICNET" are provided by the European Opendata Portal: CORDIS opendata.

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