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HollidayTrack SIGNED

Tracking the movement and dynamics of Holliday junctions

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 HollidayTrack project word cloud

Explore the words cloud of the HollidayTrack project. It provides you a very rough idea of what is the project "HollidayTrack" about.

types    biological    dynamic    intermediates    resolution    patterns    branch    stability    respect    organisation    genomic    structure    context    site    telomere    wrn    distance    biology    explore    cell    recq5    dna    stages    limited    cancer    proper    whilst    migrate    first    characterised    chromatin    migration    cells    resolved    determined    insights    sequencing    appearance    rad54    maintenance    questions    newly    hr    additionally    central    repair    omologous    chromosome    reveal    kinetics    blm    structures    valuable    ask    deficient    cellular    segregation    tool    sites    human    techniques    hjs    replication    strand    reversal    molecular    cleavage    junctions    distributions    hj    holliday    break    spontaneously    vivo    reactions    chip    recombination    translocases    vitro    domain    prevention    corresponding    plays    double    fancm    local    architecture    initiated    recq1    tools    monitor    fork    detects   

Project "HollidayTrack" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 212˙933.00

Map

 Project objective

omologous recombination (HR) is a DNA repair pathway that plays a central role in the maintenance of genomic stability and cancer prevention. In the late stages of HR, recombination intermediates (Holliday junctions, HJs) need to be resolved to allow proper chromosome segregation. Whilst HJ processing reactions have been well characterised in vitro, there is limited knowledge of the dynamic properties of these structures within a cellular context. To explore the biological properties of HJs in vivo, I will use site-specific DNA cleavage and ChIP-sequencing techniques to reveal the distance of HJ migration from the site where HR is initiated. The ability of HJs to branch migrate spontaneously or be driven by potential HJ translocases will be determined using RAD54, BLM, WRN, RECQ1, RECQ5 and FANCM deficient cells. To enable these studies, my first challenge will be to develop a molecular tool that specifically detects HJs in vivo, that can be used to monitor the appearance and kinetics of HJs after DNA double strand break formation. The specific DNA break sites and corresponding HJ migration will be determined with respect to the dynamic chromosome domain architecture and organisation within human cells, which will provide valuable insights into the impact of local chromatin structure on HJ migration and resolution. Additionally, the newly developed HJ-specific tools may be applied to ask a wide range of questions relating to the role of HJs in telomere biology and replication fork reversal or to study patterns and distributions of HJ formation and migration in different cancer cell types.

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The information about "HOLLIDAYTRACK" are provided by the European Opendata Portal: CORDIS opendata.

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