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HollidayTrack SIGNED

Tracking the movement and dynamics of Holliday junctions

Total Cost €


EC-Contrib. €






 HollidayTrack project word cloud

Explore the words cloud of the HollidayTrack project. It provides you a very rough idea of what is the project "HollidayTrack" about.

human    organisation    recq1    telomere    repair    respect    reversal    site    wrn    biological    strand    plays    questions    cell    structures    prevention    molecular    double    characterised    biology    newly    reveal    architecture    cellular    detects    stability    fork    proper    valuable    resolved    maintenance    cleavage    determined    chromatin    genomic    recombination    hjs    translocases    omologous    migration    vivo    kinetics    migrate    junctions    vitro    distance    break    deficient    intermediates    tools    stages    initiated    fancm    appearance    whilst    cancer    dynamic    recq5    cells    tool    explore    techniques    reactions    patterns    limited    branch    structure    replication    sequencing    resolution    blm    context    chromosome    types    holliday    central    segregation    additionally    rad54    chip    spontaneously    domain    monitor    first    distributions    ask    local    hj    insights    sites    dna    corresponding    hr   

Project "HollidayTrack" data sheet

The following table provides information about the project.


Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

omologous recombination (HR) is a DNA repair pathway that plays a central role in the maintenance of genomic stability and cancer prevention. In the late stages of HR, recombination intermediates (Holliday junctions, HJs) need to be resolved to allow proper chromosome segregation. Whilst HJ processing reactions have been well characterised in vitro, there is limited knowledge of the dynamic properties of these structures within a cellular context. To explore the biological properties of HJs in vivo, I will use site-specific DNA cleavage and ChIP-sequencing techniques to reveal the distance of HJ migration from the site where HR is initiated. The ability of HJs to branch migrate spontaneously or be driven by potential HJ translocases will be determined using RAD54, BLM, WRN, RECQ1, RECQ5 and FANCM deficient cells. To enable these studies, my first challenge will be to develop a molecular tool that specifically detects HJs in vivo, that can be used to monitor the appearance and kinetics of HJs after DNA double strand break formation. The specific DNA break sites and corresponding HJ migration will be determined with respect to the dynamic chromosome domain architecture and organisation within human cells, which will provide valuable insights into the impact of local chromatin structure on HJ migration and resolution. Additionally, the newly developed HJ-specific tools may be applied to ask a wide range of questions relating to the role of HJs in telomere biology and replication fork reversal or to study patterns and distributions of HJ formation and migration in different cancer cell types.

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The information about "HOLLIDAYTRACK" are provided by the European Opendata Portal: CORDIS opendata.

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