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HollidayTrack SIGNED

Tracking the movement and dynamics of Holliday junctions

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 HollidayTrack project word cloud

Explore the words cloud of the HollidayTrack project. It provides you a very rough idea of what is the project "HollidayTrack" about.

segregation    fancm    central    distance    holliday    vitro    rad54    dynamic    determined    migrate    deficient    genomic    repair    sites    structures    whilst    kinetics    resolved    chromosome    cancer    valuable    appearance    break    resolution    insights    limited    branch    hj    newly    cell    chip    maintenance    double    reversal    chromatin    recq5    tool    characterised    corresponding    initiated    spontaneously    questions    hjs    sequencing    organisation    human    domain    additionally    wrn    reveal    local    techniques    ask    first    stages    cells    structure    proper    recombination    cellular    hr    vivo    omologous    patterns    blm    stability    biology    site    detects    tools    translocases    intermediates    plays    distributions    reactions    prevention    explore    architecture    context    migration    types    fork    replication    dna    strand    recq1    junctions    telomere    cleavage    biological    respect    monitor    molecular   

Project "HollidayTrack" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 212˙933.00

Map

 Project objective

omologous recombination (HR) is a DNA repair pathway that plays a central role in the maintenance of genomic stability and cancer prevention. In the late stages of HR, recombination intermediates (Holliday junctions, HJs) need to be resolved to allow proper chromosome segregation. Whilst HJ processing reactions have been well characterised in vitro, there is limited knowledge of the dynamic properties of these structures within a cellular context. To explore the biological properties of HJs in vivo, I will use site-specific DNA cleavage and ChIP-sequencing techniques to reveal the distance of HJ migration from the site where HR is initiated. The ability of HJs to branch migrate spontaneously or be driven by potential HJ translocases will be determined using RAD54, BLM, WRN, RECQ1, RECQ5 and FANCM deficient cells. To enable these studies, my first challenge will be to develop a molecular tool that specifically detects HJs in vivo, that can be used to monitor the appearance and kinetics of HJs after DNA double strand break formation. The specific DNA break sites and corresponding HJ migration will be determined with respect to the dynamic chromosome domain architecture and organisation within human cells, which will provide valuable insights into the impact of local chromatin structure on HJ migration and resolution. Additionally, the newly developed HJ-specific tools may be applied to ask a wide range of questions relating to the role of HJs in telomere biology and replication fork reversal or to study patterns and distributions of HJ formation and migration in different cancer cell types.

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The information about "HOLLIDAYTRACK" are provided by the European Opendata Portal: CORDIS opendata.

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