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SILIA SIGNED

Solid Immersion Lens Microscopy to Study Cilia Assembly

Total Cost €

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EC-Contrib. €

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Partnership

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 SILIA project word cloud

Explore the words cloud of the SILIA project. It provides you a very rough idea of what is the project "SILIA" about.

human    self    broaden    broad    reconstitution    organelles    orchestrated    place    dynamic    principles    largely    od    parasites    omnipresence    employing    spectrum    domains    ciliopathies    budding    intraflagellar    explains    symptoms    immersion    correlative    unraveling    unknown    ing    synthetic    body    lab    vesicles    achievements    eukaryotic    flagella    domain    constituting    data    ultrastructure    sole    biological    sil    cytoskeleton    capping    lens    indispensable    signaling    proteome    cilia    congenital    cryogenic    provides    microscopy    cell    disorders    organisms    technique    light    mechanical    imaging    vitro    hampers    stabilization    integrate    cryo    ciliary    tip    functions    turning    host    motility    solid    optics    transport    evolutionary    cilium    sensing    model    organization    mechanistic    biology    enigmatic    vital    trypanosomatids    point    therapeutic    electron    project    conserved    gain    environment    trains    survival    structures   

Project "SILIA" data sheet

The following table provides information about the project.

Coordinator
USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE 

Organization address
address: VIDENSKA 1083
city: PRAHA 4
postcode: 142 20
website: www.img.cas.cz

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Total cost 156˙980 €
 EC max contribution 156˙980 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-04   to  2021-09-27

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE CZ (PRAHA 4) coordinator 156˙980.00

Map

 Project objective

Cilia and flagella are evolutionary conserved organelles indispensable for vital processes in eukaryotic organisms, such as environment sensing, cell motility, signaling and development. Broad spectrum of ciliary functions, together with omnipresence of the cilium throughout human body, explains the range of symptoms associated with congenital ciliary disorders called ciliopathies. On the other hand, cilia are essential for survival of parasites, such as trypanosomatids, in the host. Therefore, cilia are of great interest as a potential therapeutic target. The ciliary tip is an essential ciliary domain; it provides capping and mechanical stabilization of the ciliary cytoskeleton, it is a turning point of the intraflagellar transport trains, a sole place of cilium growth and a place of budding of signaling vesicles. Yet the tip is the most enigmatic of all ciliary domains, with structures constituting the ciliary tip largely unknown. This hampers our understanding of how are the tip-related processes brought about and orchestrated. To gain insight into the dynamic ultrastructure od the ciliary tip, I will develop a novel technique for cryogenic correlative light and electron microscopy based on solid immersion lens (SIL) optics. I will integrate the resulting imaging data with the tip proteome project project carried out by the host lab and provide mechanistic understanding of the resulting tip model by employing top-down synthetic biology and in vitro reconstitution approaches. Key achievements of this project will include: (i) development of the cryo-SIL technique and (ii) unraveling the functions of the the ciliary tip domain, which will broaden our knowledge of the principles of self-organization of biological systems.

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The information about "SILIA" are provided by the European Opendata Portal: CORDIS opendata.

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