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Super Time-resolved Fluorescence Anisotropy with Switchable States

Total Cost €


EC-Contrib. €






 STARSS project word cloud

Explore the words cloud of the STARSS project. It provides you a very rough idea of what is the project "STARSS" about.

overcoming    capability    micro    technique    practically    lifetime    screening    diffusion    molecular    time    nano    few    resolved    quantify    transitions    nanoseconds    interaction    shedding    biology    revolutionize    reversibly    rotational    dynamics    cells    limits    discern    bound    aggregates    scales    anisotropy    conformational    unlimited    multitude    sizes    small    sensible    drug    designed    techniques    biomedical    translates    precision    imposed    complexes    enormous    named    despite    compartments    measuring    employed    seconds    mobility    probing    light    experimental    interactions    protein    microscopy    upper    biological    living    powerful    tool    setting    favorable    coupling    inside    practical    inability    switchable    tools    lasts    situ    clusters    viable    discovery    nanometers    finite    fluorescence    free    limit    cell    starss    limiting    binding    rotating    reveal    size    observables    fa    fluorescent    molecules    throughput    angular    super   

Project "STARSS" data sheet

The following table provides information about the project.


Organization address
postcode: 100 44

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 191˙852 €
 EC max contribution 191˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Viable experimental techniques able to reveal and quantify protein-protein interactions and protein conformational changes can have a significant impact on cell biology and drug discovery. Fluorescence anisotropy (FA) has been widely employed in biomedical research as a tool for high-throughput screening applications, to study the binding of small molecules to protein and characterize protein-protein interaction. Despite the enormous potential of the FA technique, the major limiting factor is the inability of probing the system past the fluorescence lifetime, which in the most favorable cases lasts for a few nanoseconds, setting an upper limit to the time scales that can be addressed with the technique, which translates in an upper limit of few nanometers of molecular size. Reversibly switchable fluorescent transitions have the potential to revolutionize the capability of FA tools for the study of large molecular aggregates, overcoming the limits imposed by the finite fluorescence lifetime, and providing a practical and highly sensible way of measuring rotational diffusion processes with a practically unlimited upper bound on molecular sizes. This proposal aims to develop a novel fluorescent anisotropy technique, named Super Time-resolved Anisotropy with Reversibly Switchable States (STARSS), designed to measure rotational mobility all-across the time scale from nano- to micro-seconds, which will enable to discern clusters from free rotating molecules in situ and with high angular precision. The coupling of STARSS observables and microscopy will provide a powerful tool to reveal the dynamics of protein complexes inside the compartments of living cells, shedding new light on a multitude of biological processes.

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The information about "STARSS" are provided by the European Opendata Portal: CORDIS opendata.

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