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MiMoZa SIGNED

Microbiota modulation through horizontal gene transfer.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MiMoZa project word cloud

Explore the words cloud of the MiMoZa project. It provides you a very rough idea of what is the project "MiMoZa" about.

residing    cocktails    experimentally    gastro    infection    health    possibilities    species    resident    initial    influencing    tract    difficult    connected    metagenomic    engraftment    lifestyle    stimulate    intestinal    serve    gut    sizes    intimately    rates    probiotic    transfer    material    small    competition    changing    natural    host    dna    exchange    spread    altering    gene    bodies    strategies    realization    successes    agricultural    ilana    pressure    msca    relative    microbiome    stay    ways    modulation    hgt    successful    gm    nor    dietary    human    limit    functions    datasets    transfers    fecal    medication    my    microbes    horizontal    brito    strain    examine    contacted    environments    time    policies    additional    transgenes    treatment    transit    immune    alternative    fellowship    lab    abundances    effect    raes    diet    led    composition    function    myriad    little    jeroen    modulate    animal    selective    prokaryotes    despite    difficile    genetic    antibiotic    implications    microbiota   

Project "MiMoZa" data sheet

The following table provides information about the project.

Coordinator
VIB 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 266˙425 €
 EC max contribution 266˙425 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-GF
 Starting year 2020
 Duration (year-month-day) from 2020-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB BE (ZWIJNAARDE - GENT) coordinator 266˙425.00
2    CORNELL UNIVERSITY US (ITHACA NY) partner 0.00

Map

 Project objective

My goal is to determine horizontal gene transfer (HGT) rates of specific functions within the gut microbiome. The microbes on and within our bodies, especially within our gastro-intestinal tract, are intimately connected with our immune system and promote health in myriad ways. Altering our gut microbiota (GM) composition and/or function might thus improve health. My research in the Jeroen Raes lab led to the realization that changing species abundances through dietary or lifestyle modulation may be difficult because of the small effect sizes of the factors influencing GM composition (e.g. diet, medication, or transit time). In addition, host-selection and competition of resident microbes, might limit the strain engraftment necessary for the effect of fecal transfers and probiotic cocktails. Despite initial successes (e.g. C. difficile infection treatment), current modulation strategies might therefore be less successful with other conditions. I contacted Ilana Brito, in order to find out whether HGT - a process in which prokaryotes exchange genetic material - may serve as an alternative way to modulate the residing GM. Little is known about the features that affect HGT rates within natural environments nor the role of selection in that process. If these were well-understood, it would allow to assess the possibilities of extending the gut microbiome with additional functions. During my research stay, I will experimentally determine HGT rates within the animal gut under natural and HGT-enhancing conditions. In addition, I will develop methods to examine HGT in metagenomic datasets and determine the relative importance of the factors influencing HGT (selective pressure, host health and DNA delivery method). The knowledge generated through this MSCA-fellowship will stimulate the development of novel GM modulation strategies and will have important implications for human health and agricultural policies (e.g. antibiotic use, spread of transgenes).

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The information about "MIMOZA" are provided by the European Opendata Portal: CORDIS opendata.

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