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MiMoZa SIGNED

Microbiota modulation through horizontal gene transfer.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MiMoZa project word cloud

Explore the words cloud of the MiMoZa project. It provides you a very rough idea of what is the project "MiMoZa" about.

policies    nor    intimately    animal    residing    horizontal    gm    resident    modulation    antibiotic    transit    altering    treatment    gastro    little    spread    possibilities    abundances    prokaryotes    difficult    ilana    metagenomic    msca    time    natural    immune    serve    rates    changing    examine    exchange    tract    material    function    dna    alternative    datasets    additional    hgt    intestinal    transfers    cocktails    sizes    pressure    strain    limit    microbes    brito    jeroen    influencing    bodies    engraftment    selective    realization    health    effect    species    successes    microbiota    raes    host    led    gene    environments    genetic    relative    stimulate    functions    myriad    fecal    difficile    despite    connected    ways    probiotic    composition    stay    diet    microbiome    transfer    gut    strategies    experimentally    transgenes    initial    lab    medication    dietary    modulate    contacted    lifestyle    human    successful    implications    competition    fellowship    infection    my    agricultural    small   

Project "MiMoZa" data sheet

The following table provides information about the project.

Coordinator
VIB 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 266˙425 €
 EC max contribution 266˙425 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-GF
 Starting year 2020
 Duration (year-month-day) from 2020-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB BE (ZWIJNAARDE - GENT) coordinator 266˙425.00
2    CORNELL UNIVERSITY US (ITHACA NY) partner 0.00

Map

 Project objective

My goal is to determine horizontal gene transfer (HGT) rates of specific functions within the gut microbiome. The microbes on and within our bodies, especially within our gastro-intestinal tract, are intimately connected with our immune system and promote health in myriad ways. Altering our gut microbiota (GM) composition and/or function might thus improve health. My research in the Jeroen Raes lab led to the realization that changing species abundances through dietary or lifestyle modulation may be difficult because of the small effect sizes of the factors influencing GM composition (e.g. diet, medication, or transit time). In addition, host-selection and competition of resident microbes, might limit the strain engraftment necessary for the effect of fecal transfers and probiotic cocktails. Despite initial successes (e.g. C. difficile infection treatment), current modulation strategies might therefore be less successful with other conditions. I contacted Ilana Brito, in order to find out whether HGT - a process in which prokaryotes exchange genetic material - may serve as an alternative way to modulate the residing GM. Little is known about the features that affect HGT rates within natural environments nor the role of selection in that process. If these were well-understood, it would allow to assess the possibilities of extending the gut microbiome with additional functions. During my research stay, I will experimentally determine HGT rates within the animal gut under natural and HGT-enhancing conditions. In addition, I will develop methods to examine HGT in metagenomic datasets and determine the relative importance of the factors influencing HGT (selective pressure, host health and DNA delivery method). The knowledge generated through this MSCA-fellowship will stimulate the development of novel GM modulation strategies and will have important implications for human health and agricultural policies (e.g. antibiotic use, spread of transgenes).

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The information about "MIMOZA" are provided by the European Opendata Portal: CORDIS opendata.

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