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MiMoZa SIGNED

Microbiota modulation through horizontal gene transfer.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MiMoZa project word cloud

Explore the words cloud of the MiMoZa project. It provides you a very rough idea of what is the project "MiMoZa" about.

pressure    modulate    intestinal    msca    health    metagenomic    myriad    abundances    serve    composition    little    medication    difficult    tract    gut    gene    small    brito    additional    functions    sizes    altering    treatment    led    residing    spread    host    modulation    intimately    contacted    experimentally    rates    gastro    species    transit    microbiome    antibiotic    animal    possibilities    policies    transfer    horizontal    ilana    lab    cocktails    realization    alternative    transgenes    transfers    material    my    bodies    prokaryotes    implications    successes    selective    connected    datasets    engraftment    relative    gm    despite    agricultural    fecal    exchange    dietary    immune    nor    jeroen    function    effect    examine    strain    environments    initial    difficile    microbiota    dna    hgt    resident    successful    stay    fellowship    microbes    ways    human    stimulate    changing    strategies    natural    influencing    limit    time    genetic    competition    probiotic    lifestyle    infection    raes    diet   

Project "MiMoZa" data sheet

The following table provides information about the project.

Coordinator
VIB 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 266˙425 €
 EC max contribution 266˙425 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-GF
 Starting year 2020
 Duration (year-month-day) from 2020-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB BE (ZWIJNAARDE - GENT) coordinator 266˙425.00
2    CORNELL UNIVERSITY US (ITHACA NY) partner 0.00

Map

 Project objective

My goal is to determine horizontal gene transfer (HGT) rates of specific functions within the gut microbiome. The microbes on and within our bodies, especially within our gastro-intestinal tract, are intimately connected with our immune system and promote health in myriad ways. Altering our gut microbiota (GM) composition and/or function might thus improve health. My research in the Jeroen Raes lab led to the realization that changing species abundances through dietary or lifestyle modulation may be difficult because of the small effect sizes of the factors influencing GM composition (e.g. diet, medication, or transit time). In addition, host-selection and competition of resident microbes, might limit the strain engraftment necessary for the effect of fecal transfers and probiotic cocktails. Despite initial successes (e.g. C. difficile infection treatment), current modulation strategies might therefore be less successful with other conditions. I contacted Ilana Brito, in order to find out whether HGT - a process in which prokaryotes exchange genetic material - may serve as an alternative way to modulate the residing GM. Little is known about the features that affect HGT rates within natural environments nor the role of selection in that process. If these were well-understood, it would allow to assess the possibilities of extending the gut microbiome with additional functions. During my research stay, I will experimentally determine HGT rates within the animal gut under natural and HGT-enhancing conditions. In addition, I will develop methods to examine HGT in metagenomic datasets and determine the relative importance of the factors influencing HGT (selective pressure, host health and DNA delivery method). The knowledge generated through this MSCA-fellowship will stimulate the development of novel GM modulation strategies and will have important implications for human health and agricultural policies (e.g. antibiotic use, spread of transgenes).

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The information about "MIMOZA" are provided by the European Opendata Portal: CORDIS opendata.

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