Opendata, web and dolomites
MiMoZa SIGNED
Microbiota modulation through horizontal gene transfer.
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0MiMoZa project word cloud
Explore the words cloud of the MiMoZa project. It provides you a very rough idea of what is the project "MiMoZa" about.
engraftment
pressure
time
competition
implications
changing
microbes
relative
immune
species
abundances
realization
infection
policies
brito
antibiotic
probiotic
medication
selective
transit
functions
metagenomic
spread
nor
human
lifestyle
sizes
msca
serve
stimulate
difficult
horizontal
raes
jeroen
alternative
small
successes
transgenes
tract
natural
hgt
fecal
exchange
dietary
despite
host
strain
effect
microbiome
successful
little
modulation
genetic
composition
additional
agricultural
datasets
material
difficile
examine
microbiota
fellowship
transfers
gastro
resident
myriad
modulate
rates
gut
treatment
residing
dna
altering
environments
limit
gene
led
intimately
lab
stay
function
diet
gm
connected
my
initial
ilana
bodies
strategies
possibilities
influencing
ways
cocktails
contacted
health
experimentally
transfer
intestinal
prokaryotes
animal
Project "MiMoZa" data sheet
The following table provides information about the project.
| Coordinator |
VIB
Organization address contact info |
| Coordinator Country | Belgium [BE] |
| Total cost | 266˙425 € |
| EC max contribution | 266˙425 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2019 |
| Funding Scheme | MSCA-IF-GF |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-08-01 to 2023-07-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | VIB | BE (ZWIJNAARDE - GENT) | coordinator | 266˙425.00 |
| 2 | CORNELL UNIVERSITY | US (ITHACA NY) | partner | 0.00 |
Map
Project objective
My goal is to determine horizontal gene transfer (HGT) rates of specific functions within the gut microbiome. The microbes on and within our bodies, especially within our gastro-intestinal tract, are intimately connected with our immune system and promote health in myriad ways. Altering our gut microbiota (GM) composition and/or function might thus improve health. My research in the Jeroen Raes lab led to the realization that changing species abundances through dietary or lifestyle modulation may be difficult because of the small effect sizes of the factors influencing GM composition (e.g. diet, medication, or transit time). In addition, host-selection and competition of resident microbes, might limit the strain engraftment necessary for the effect of fecal transfers and probiotic cocktails. Despite initial successes (e.g. C. difficile infection treatment), current modulation strategies might therefore be less successful with other conditions. I contacted Ilana Brito, in order to find out whether HGT - a process in which prokaryotes exchange genetic material - may serve as an alternative way to modulate the residing GM. Little is known about the features that affect HGT rates within natural environments nor the role of selection in that process. If these were well-understood, it would allow to assess the possibilities of extending the gut microbiome with additional functions. During my research stay, I will experimentally determine HGT rates within the animal gut under natural and HGT-enhancing conditions. In addition, I will develop methods to examine HGT in metagenomic datasets and determine the relative importance of the factors influencing HGT (selective pressure, host health and DNA delivery method). The knowledge generated through this MSCA-fellowship will stimulate the development of novel GM modulation strategies and will have important implications for human health and agricultural policies (e.g. antibiotic use, spread of transgenes).
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The information about "MIMOZA" are provided by the European Opendata Portal: CORDIS opendata.
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