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MiMoZa SIGNED

Microbiota modulation through horizontal gene transfer.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MiMoZa project word cloud

Explore the words cloud of the MiMoZa project. It provides you a very rough idea of what is the project "MiMoZa" about.

abundances    msca    agricultural    time    raes    prokaryotes    modulate    datasets    realization    treatment    infection    diet    limit    medication    initial    microbes    transit    function    altering    despite    brito    little    lab    modulation    tract    intimately    genetic    antibiotic    ways    rates    nor    horizontal    cocktails    gene    spread    stimulate    resident    selective    serve    fecal    environments    successful    dna    gut    functions    policies    bodies    composition    strain    small    transfers    strategies    animal    examine    ilana    gm    relative    my    experimentally    additional    species    transgenes    connected    fellowship    probiotic    immune    led    implications    dietary    competition    metagenomic    changing    engraftment    difficile    myriad    possibilities    natural    successes    exchange    pressure    microbiome    influencing    hgt    transfer    health    jeroen    material    residing    human    sizes    effect    microbiota    host    lifestyle    stay    gastro    contacted    alternative    difficult    intestinal   

Project "MiMoZa" data sheet

The following table provides information about the project.

Coordinator
VIB 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 266˙425 €
 EC max contribution 266˙425 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-GF
 Starting year 2020
 Duration (year-month-day) from 2020-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB BE (ZWIJNAARDE - GENT) coordinator 266˙425.00
2    CORNELL UNIVERSITY US (ITHACA NY) partner 0.00

Map

 Project objective

My goal is to determine horizontal gene transfer (HGT) rates of specific functions within the gut microbiome. The microbes on and within our bodies, especially within our gastro-intestinal tract, are intimately connected with our immune system and promote health in myriad ways. Altering our gut microbiota (GM) composition and/or function might thus improve health. My research in the Jeroen Raes lab led to the realization that changing species abundances through dietary or lifestyle modulation may be difficult because of the small effect sizes of the factors influencing GM composition (e.g. diet, medication, or transit time). In addition, host-selection and competition of resident microbes, might limit the strain engraftment necessary for the effect of fecal transfers and probiotic cocktails. Despite initial successes (e.g. C. difficile infection treatment), current modulation strategies might therefore be less successful with other conditions. I contacted Ilana Brito, in order to find out whether HGT - a process in which prokaryotes exchange genetic material - may serve as an alternative way to modulate the residing GM. Little is known about the features that affect HGT rates within natural environments nor the role of selection in that process. If these were well-understood, it would allow to assess the possibilities of extending the gut microbiome with additional functions. During my research stay, I will experimentally determine HGT rates within the animal gut under natural and HGT-enhancing conditions. In addition, I will develop methods to examine HGT in metagenomic datasets and determine the relative importance of the factors influencing HGT (selective pressure, host health and DNA delivery method). The knowledge generated through this MSCA-fellowship will stimulate the development of novel GM modulation strategies and will have important implications for human health and agricultural policies (e.g. antibiotic use, spread of transgenes).

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The information about "MIMOZA" are provided by the European Opendata Portal: CORDIS opendata.

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