Opendata, web and dolomites


Assessing cardiac Contractility and Quantification of Underlying mechanisms In vitro via Response in Excitation-contraction coupling

Total Cost €


EC-Contrib. €






 ACQUIRE project word cloud

Explore the words cloud of the ACQUIRE project. It provides you a very rough idea of what is the project "ACQUIRE" about.

detect    larger    myocardium    ttm    cell    electrical    cardiomyocytes    triple    fall    compete    contraction    commercial    cardiomyocyte    diseases    appropriate    minimum    cardiotoxicity    erc    incompatible    applicable    contractility    abnormal    coupling    strive    discovery    calcium    cm    stem    proven    quantify    apart    variety    probes    cardiac    bioassays    later    flexibility    mechanistic    answer    ing    readouts    proof    software    ec    paucity    disease    models    cms    commercialisation    toxic    handling    simultaneously    assay    service    biologically    throughput    intracellular    pharma    urgently    friendliness    acquire    drugs    sensitive    academia    heart    tools    stemcardiovasc    hipsc    modules    human    analysing    quantifies    pluripotent    outcome    accommodate    industry    function    3d    entailed    tissue    route    informative    accurate    grant    drug    transient    flux    optical    running    integrating    tool    commercialized   

Project "ACQUIRE" data sheet

The following table provides information about the project.


Organization address
city: LEIDEN
postcode: 2333 ZA

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2021-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) coordinator 150˙000.00


 Project objective

'Academia and industry urgently needs reliable models to study heart failure and toxic effects of drugs on the heart. While new models based on human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are now emerging, accurate readouts of cardiomyocyte function fall short of needs. Apart from improving the models biologically, more sensitive, informative and accurate readouts are needed to detect abnormal cardiomyocyte behaviour. Several tools have proven their ability to assess electrical changes or calcium handling in hiPSC-CMs, but they are typically incompatible with 3D tissue models and moreover, there is paucity of appropriate tools to quantify the most important function of myocardium: contraction. Our ERC Advanced Grant STEMCARDIOVASC entailed the development of improved tools for cardiac functionality. One of the most important bioassays developed as an outcome of STEMCARDIOVASC was the Triple Transient Measurement (TTM) System. The TTM System quantifies electrical activity, intracellular calcium flux and contractility simultaneously and is our answer to the challenge of pharma in understanding when and how drugs or diseases affect cardiac contractility using hiPSC-CM models. In this ERC Proof of Concept project “ACQUIRE”, we strive to bring the TTM to a commercial applicable service, and later product. To reach this goal we have set out four aims to come to a Minimum Viable Product: i) increase the flexibility of the system to accommodate a larger variety of optical probes, ii) increase the throughput of the system to compete with current measurement systems, iii) increase user friendliness by integrating software modules for running and analysing measurements and iv) define a route for commercialisation. Resulting from 'ACQUIRE' the TTM System can be commercialized as a human cardiac based 3-in-1 assay for cardiotoxicity testing and a novel tool for providing mechanistic insight in the EC coupling for disease modelling and drug discovery.'

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ACQUIRE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ACQUIRE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)


The Enemy of the Good: Towards a Theory of Moral Progress

Read More  

VictPart (2019)

Righting Victim Participation in Transitional Justice

Read More  

Photopharm (2020)

Photopharmacology: From Academia toward the Clinic.

Read More