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ACQUIRE SIGNED

Assessing cardiac Contractility and Quantification of Underlying mechanisms In vitro via Response in Excitation-contraction coupling

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ACQUIRE project word cloud

Explore the words cloud of the ACQUIRE project. It provides you a very rough idea of what is the project "ACQUIRE" about.

tissue    contraction    cm    outcome    pluripotent    commercialisation    cms    incompatible    friendliness    cardiomyocytes    minimum    flexibility    mechanistic    informative    modules    proof    function    3d    stem    human    tool    handling    proven    ing    detect    electrical    coupling    cardiomyocyte    transient    drugs    readouts    biologically    industry    accurate    integrating    calcium    answer    simultaneously    quantify    contractility    myocardium    probes    entailed    later    assay    drug    heart    applicable    erc    strive    analysing    sensitive    acquire    hipsc    larger    disease    stemcardiovasc    commercialized    throughput    bioassays    tools    models    paucity    triple    toxic    compete    route    optical    service    cell    academia    running    abnormal    discovery    pharma    ec    software    commercial    quantifies    apart    appropriate    fall    grant    intracellular    flux    diseases    ttm    cardiotoxicity    variety    accommodate    cardiac    urgently   

Project "ACQUIRE" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS LEIDEN 

Organization address
address: ALBINUSDREEF 2
city: LEIDEN
postcode: 2333 ZA
website: www.lumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) coordinator 150˙000.00

Map

 Project objective

'Academia and industry urgently needs reliable models to study heart failure and toxic effects of drugs on the heart. While new models based on human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are now emerging, accurate readouts of cardiomyocyte function fall short of needs. Apart from improving the models biologically, more sensitive, informative and accurate readouts are needed to detect abnormal cardiomyocyte behaviour. Several tools have proven their ability to assess electrical changes or calcium handling in hiPSC-CMs, but they are typically incompatible with 3D tissue models and moreover, there is paucity of appropriate tools to quantify the most important function of myocardium: contraction. Our ERC Advanced Grant STEMCARDIOVASC entailed the development of improved tools for cardiac functionality. One of the most important bioassays developed as an outcome of STEMCARDIOVASC was the Triple Transient Measurement (TTM) System. The TTM System quantifies electrical activity, intracellular calcium flux and contractility simultaneously and is our answer to the challenge of pharma in understanding when and how drugs or diseases affect cardiac contractility using hiPSC-CM models. In this ERC Proof of Concept project “ACQUIRE”, we strive to bring the TTM to a commercial applicable service, and later product. To reach this goal we have set out four aims to come to a Minimum Viable Product: i) increase the flexibility of the system to accommodate a larger variety of optical probes, ii) increase the throughput of the system to compete with current measurement systems, iii) increase user friendliness by integrating software modules for running and analysing measurements and iv) define a route for commercialisation. Resulting from 'ACQUIRE' the TTM System can be commercialized as a human cardiac based 3-in-1 assay for cardiotoxicity testing and a novel tool for providing mechanistic insight in the EC coupling for disease modelling and drug discovery.'

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The information about "ACQUIRE" are provided by the European Opendata Portal: CORDIS opendata.

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