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Assessing cardiac Contractility and Quantification of Underlying mechanisms In vitro via Response in Excitation-contraction coupling

Total Cost €


EC-Contrib. €






 ACQUIRE project word cloud

Explore the words cloud of the ACQUIRE project. It provides you a very rough idea of what is the project "ACQUIRE" about.

electrical    tool    informative    acquire    commercial    proven    ec    strive    quantifies    route    software    service    myocardium    abnormal    cardiomyocyte    cardiomyocytes    fall    accommodate    answer    stem    mechanistic    detect    human    erc    heart    models    quantify    coupling    paucity    analysing    drugs    cardiotoxicity    stemcardiovasc    industry    readouts    diseases    contractility    bioassays    simultaneously    handling    toxic    probes    academia    cardiac    proof    optical    pharma    hipsc    throughput    tools    accurate    cell    flexibility    commercialized    modules    apart    contraction    appropriate    friendliness    function    3d    integrating    triple    entailed    cm    variety    tissue    flux    pluripotent    grant    compete    sensitive    intracellular    cms    running    applicable    larger    assay    disease    discovery    transient    minimum    later    incompatible    calcium    ttm    biologically    urgently    drug    commercialisation    outcome    ing   

Project "ACQUIRE" data sheet

The following table provides information about the project.


Organization address
city: LEIDEN
postcode: 2333 ZA

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2021-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) coordinator 150˙000.00


 Project objective

'Academia and industry urgently needs reliable models to study heart failure and toxic effects of drugs on the heart. While new models based on human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are now emerging, accurate readouts of cardiomyocyte function fall short of needs. Apart from improving the models biologically, more sensitive, informative and accurate readouts are needed to detect abnormal cardiomyocyte behaviour. Several tools have proven their ability to assess electrical changes or calcium handling in hiPSC-CMs, but they are typically incompatible with 3D tissue models and moreover, there is paucity of appropriate tools to quantify the most important function of myocardium: contraction. Our ERC Advanced Grant STEMCARDIOVASC entailed the development of improved tools for cardiac functionality. One of the most important bioassays developed as an outcome of STEMCARDIOVASC was the Triple Transient Measurement (TTM) System. The TTM System quantifies electrical activity, intracellular calcium flux and contractility simultaneously and is our answer to the challenge of pharma in understanding when and how drugs or diseases affect cardiac contractility using hiPSC-CM models. In this ERC Proof of Concept project “ACQUIRE”, we strive to bring the TTM to a commercial applicable service, and later product. To reach this goal we have set out four aims to come to a Minimum Viable Product: i) increase the flexibility of the system to accommodate a larger variety of optical probes, ii) increase the throughput of the system to compete with current measurement systems, iii) increase user friendliness by integrating software modules for running and analysing measurements and iv) define a route for commercialisation. Resulting from 'ACQUIRE' the TTM System can be commercialized as a human cardiac based 3-in-1 assay for cardiotoxicity testing and a novel tool for providing mechanistic insight in the EC coupling for disease modelling and drug discovery.'

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The information about "ACQUIRE" are provided by the European Opendata Portal: CORDIS opendata.

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