EU H2020 Project "VIRIVITES (ARBOVIRUS SKIN INFECTION MODELLING FOR MORE ACCURATE VIRAL PATHOGENESIS)": description, partecipants, costs and EC-fundings

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VirIVITES project word cloud

Explore the words cloud of the VirIVITES project. It provides you a very rough idea of what is the project "VirIVITES" about.

microscopy treat professionally followed gain tissue reconstructed arthropod comprising mosquitos arbovirus worldwide arboviruses tools human viruses nerve maturity immune transcriptomics neurons naturally links prevent dendritic inflammatory diseases skin stem pluripotent benefit contributed arboviral is scientific infection engineered proposing biomedical perform caused patients skills sensory dengue organization demonstration care infected interdisciplinary palliative excellent cells inappropriate thanks limitations cell assembly slow 24 neurological skill leaving progress stable biology feasibility pathogenesis professional arrangements although borne host ideas dimensional virology differentiation attainable experimental months soft collaborative return cultures training financing molecular single imposed macrophages overcome virus primary explore employment

Project "VirIVITES" data sheet

The following table provides information about the project.

Coordinator	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	196˙707 €
EC max contribution	196˙707 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2019
Funding Scheme	MSCA-IF-EF-RI
Starting year	2020
Duration (year-month-day)	from 2020-09-01 to 2022-08-31

#	participants	country	role	EC contrib. [€]
1	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS	FR (PARIS)	coordinator	196˙707.00

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

FR (PARIS)

coordinator

196˙707.00

Project objective

Although inflammatory and neurological diseases caused by arthropod-borne viruses progress worldwide, biomedical advances are slow, still leaving patients to palliative care. New approaches to arboviral pathogenesis are needed to overcome the limitations imposed by inappropriate experimental systems. Here I propose to use tissue-engineered human skin, comprising immune cells and sensory nerve cells, and naturally-infected mosquitos to investigate infection and cell responses to the Dengue arbovirus. I will benefit from the host organization experience to perform (i) primary and induced pluripotent stem cell cultures and differentiation of dendritic cells, macrophages and sensory neurons, followed by their three-dimensional assembly, (ii) Dengue virus infection of mosquitos and (iii) analysis of cell infection and cell responses using virology, molecular biology and microscopy tools. In return, I will apply my skills in single cell transcriptomics of skin to explore the feasibility to apply this new technology to reconstructed tissue. Thanks to excellent scientific and soft skill training as well as the favourable arrangements provided by the host organization, the deliverables of this interdisciplinary research programme should be attainable in 24 months. In addition, I aim to gain professional maturity by proposing new projects for financing as a result of ideas, knowledge and collaborative links. The demonstration that human sensory neurons are infected by the Dengue virus in reconstructed skin should make an important impact for new biomedical approaches to prevent/treat neurological diseases caused by arboviruses. My objective is also is to have contributed to the progress of the host organization while evolving professionally for a stable employment in Europe.

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