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VirIVITES SIGNED

ARBOVIRUS SKIN INFECTION MODELLING FOR MORE ACCURATE VIRAL PATHOGENESIS

Total Cost €

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EC-Contrib. €

0

Partnership

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 VirIVITES project word cloud

Explore the words cloud of the VirIVITES project. It provides you a very rough idea of what is the project "VirIVITES" about.

diseases    maturity    stable    comprising    cell    soft    employment    inappropriate    links    benefit    care    tools    single    limitations    skill    engineered    proposing    24    pathogenesis    transcriptomics    pluripotent    borne    interdisciplinary    perform    arrangements    cultures    biomedical    palliative    arbovirus    nerve    arboviruses    experimental    stem    return    mosquitos    immune    dimensional    arthropod    collaborative    ideas    professionally    overcome    viruses    neurological    macrophages    caused    sensory    dendritic    excellent    infection    thanks    imposed    human    assembly    training    feasibility    cells    financing    worldwide    scientific    although    followed    progress    contributed    naturally    treat    prevent    biology    inflammatory    virus    skin    demonstration    organization    skills    reconstructed    gain    differentiation    patients    tissue    leaving    primary    microscopy    dengue    slow    virology    arboviral    molecular    infected    explore    months    attainable    host    neurons    is    professional   

Project "VirIVITES" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 196˙707.00

Map

 Project objective

Although inflammatory and neurological diseases caused by arthropod-borne viruses progress worldwide, biomedical advances are slow, still leaving patients to palliative care. New approaches to arboviral pathogenesis are needed to overcome the limitations imposed by inappropriate experimental systems. Here I propose to use tissue-engineered human skin, comprising immune cells and sensory nerve cells, and naturally-infected mosquitos to investigate infection and cell responses to the Dengue arbovirus. I will benefit from the host organization experience to perform (i) primary and induced pluripotent stem cell cultures and differentiation of dendritic cells, macrophages and sensory neurons, followed by their three-dimensional assembly, (ii) Dengue virus infection of mosquitos and (iii) analysis of cell infection and cell responses using virology, molecular biology and microscopy tools. In return, I will apply my skills in single cell transcriptomics of skin to explore the feasibility to apply this new technology to reconstructed tissue. Thanks to excellent scientific and soft skill training as well as the favourable arrangements provided by the host organization, the deliverables of this interdisciplinary research programme should be attainable in 24 months. In addition, I aim to gain professional maturity by proposing new projects for financing as a result of ideas, knowledge and collaborative links. The demonstration that human sensory neurons are infected by the Dengue virus in reconstructed skin should make an important impact for new biomedical approaches to prevent/treat neurological diseases caused by arboviruses. My objective is also is to have contributed to the progress of the host organization while evolving professionally for a stable employment in Europe.

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The information about "VIRIVITES" are provided by the European Opendata Portal: CORDIS opendata.

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