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MATBFOB SIGNED

MAThematical modelling of Biofilm FOrmation on Biomaterials

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MATBFOB project word cloud

Explore the words cloud of the MATBFOB project. It provides you a very rough idea of what is the project "MATBFOB" about.

implant    nosocomial    detachment    substrate    experimental    bacterial    considering    cardiac    pseudomonas    simulate    visualising    manufacturers    pathogen    effect    observations    employ    surface    medical    mass    models    modellers    suitable    biomaterials    treatment    adhesion    biofilms    mathematically    little    brand    microbes    manner    tool    brief    urinary    wastewater    mathematical    couple    initiation    pivotal    aeruginosa    monitoring    forces    orthopaedic    structures    spread    fundamental    spatio    rate    morphology    healthcare    microbial    consists    correlate    originate    surfaces    surgeons    characterizing    model    colonies    tools    catheters    pacemakers    exact    guided    interactions    indwelling    stages    dynamics    biofilm    precise    deciphering    interaction    gradual    biomaterial    elucidate    progression    time    nutrient    acknowledged    scientists    transfer    implants    vascular    of    temporal    establishment    infections    microbiologists    microbe    play    endeavour   

Project "MATBFOB" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EXETER 

Organization address
address: THE QUEEN'S DRIVE NORTHCOTE HOUSE
city: EXETER
postcode: EX4 4QJ
website: www.ex.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 337˙400 €
 EC max contribution 337˙400 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EXETER UK (EXETER) coordinator 337˙400.00

Map

 Project objective

Biofilms play a pivotal role in healthcare-associated infections, especially those related to indwelling medical devices, such as intra-vascular and urinary catheters, cardiac pacemakers and orthopaedic implants. Many mathematical models have been developed to simulate and elucidate the main processes characterizing biofilm growth. Biofilm models have been widely acknowledged as a tool for fundamental understanding of wastewater treatment processes, the morphology of biofilm structures and for deciphering the manner in which they originate through the interaction of a couple of factors like: mass transfer, nutrient availability, detachment forces etc. However there has been very little or no endeavour to develop a suitable model for understanding the exact stages of microbial adhesion on biomaterials and the process of gradual establishment of microbial colonies on medical devices, considering the effect of substrate-microbe interactions . The proposed project consists of a brief and precise experimental part for investigating the initiation and progression of biofilm formation of Pseudomonas aeruginosa, a nosocomial pathogen, on implant surfaces through real-time monitoring. The experimental observations will be used to mathematically model the process of growth of biofilm on a biomaterial surface, considering the effect of interactions of microbes with a specific substrate and the rate of nutrient uptake.The project will employ currently used mathematical tools to model the spatio-temporal dynamics of biofilm formation of Pseudomonas aeruginosa on different biomaterial surfaces.The model will help in visualising the manner and the rate at which bacterial infections can spread on a particular surface and correlate it with the surface properties. This will be the initiation of - model guided substrate design of implants- a brand new concept for implant manufacturers, orthopaedic surgeons, biomaterial scientists, microbiologists and biofilm modellers.

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The information about "MATBFOB" are provided by the European Opendata Portal: CORDIS opendata.

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