TIMER

TargetIng novel MEchanisms of Resolution in inflammation

 Coordinatore FONDAZIONE HUMANITAS PER LA RICERCA 

 Organization address address: Via Manzoni 56
city: ROZZANO
postcode: 20089

contact info
Titolo: Dr.
Nome: Danilo
Cognome: Petroni
Email: send email
Telefono: +39 02 82242435
Fax: +39 02 82245191

 Nazionalità Coordinatore Italy [IT]
 Totale costo 3˙989˙175 €
 EC contributo 2˙999˙300 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2011-single-stage
 Funding Scheme CP-FP
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-01-01   -   2015-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    FONDAZIONE HUMANITAS PER LA RICERCA

 Organization address address: Via Manzoni 56
city: ROZZANO
postcode: 20089

contact info
Titolo: Dr.
Nome: Danilo
Cognome: Petroni
Email: send email
Telefono: +39 02 82242435
Fax: +39 02 82245191

IT (ROZZANO) coordinator 597˙503.54
2    FONDAZIONE PER L'ISTITUTO DI RICERC A IN BIOMEDICINA

 Organization address address: Via Vincenzo Vela 6
city: BELLINZONA
postcode: 6500

contact info
Titolo: Prof.
Nome: Giorgio
Cognome: Noseda
Email: send email
Telefono: +41 91 820 0309
Fax: +41 91 820 0305

CH (BELLINZONA) participant 363˙600.00
3    UNIVERSITY OF GLASGOW

 Organization address address: University Avenue
city: GLASGOW
postcode: G12 8QQ

contact info
Titolo: Ms.
Nome: Adriana
Cognome: Scicluna
Email: send email
Telefono: +44 141 330 4646
Fax: +44 141 330 5856

UK (GLASGOW) participant 357˙600.00
4    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

 Organization address address: College Green -
city: DUBLIN
postcode: 2

contact info
Titolo: Ms.
Nome: Deirdre
Cognome: Savage
Email: send email
Telefono: 35318961942
Fax: 35317071633

IE (DUBLIN) participant 297˙600.00
5    TELORMEDIX SA

 Organization address address: Via della Posta 10
city: Bioggio
postcode: 6934

contact info
Titolo: Dr.
Nome: Johanna
Cognome: Holldack
Email: send email
Telefono: 41916107038
Fax: 41912606836

CH (Bioggio) participant 289˙696.46
6    UNIVERSIDADE FEDERAL DE MINAS GERAIS

 Organization address address: AV. ANTONIO CARLOS - PAMPULHA 6627
city: BELO HORIZONTE MINAS GERAIS
postcode: 31270901

contact info
Titolo: Dr.
Nome: Marco Aurelio
Cognome: Crocco Afonso
Email: send email
Telefono: +55 31 3409 4200
Fax: +55 31 3409 4252

BR (BELO HORIZONTE MINAS GERAIS) participant 250˙500.00
7    FUNDACAO OSWALDO CRUZ

 Organization address address: AVENIDA BRASIL 4365
city: RIO DE JANEIRO
postcode: 21040 900

contact info
Titolo: Prof.
Nome: Adolfo Horácio
Cognome: Chorny
Email: send email
Telefono: +55 21 2209 2600
Fax: +55 21 22092295

BR (RIO DE JANEIRO) participant 222˙000.00
8    UNIVERSIDADE DE SAO PAULO

 Organization address address: RUA DA REITORIA 109 BUTANTA
city: SAO PAULO SP
postcode: 05508 900

contact info
Titolo: Prof.
Nome: Antonio Marcos De Aguirra
Cognome: Massola
Email: send email
Telefono: +55 11 3035 0550
Fax: +55 11 3035 0580

BR (SAO PAULO SP) participant 220˙800.00
9    NOVIMMUNE SA

 Organization address address: CHEMIN DES AULX 14
city: PLAN LES OUATES GENEVE
postcode: 1228

contact info
Titolo: Mrs.
Nome: Nathalie
Cognome: Muller
Email: send email
Telefono: +41 22 593 5104
Fax: +41 22 839 7143

CH (PLAN LES OUATES GENEVE) participant 163˙037.00
10    ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU

 Organization address address: VIA FIORENTINA 151
city: SIENA
postcode: 53100

contact info
Titolo: Dr.
Nome: Cristiana
Cognome: Tozzi
Email: send email
Telefono: +39 0577 587906
Fax: +39 0577 593815

IT (SIENA) participant 100˙000.00
11    DOMPE FARMACEUTICI SPA

 Organization address address: VIA S MARTINO DELLA BATTAGLIA 12
city: MILANO
postcode: 20122

contact info
Titolo: Dr.
Nome: Cinzia
Cognome: D'ettorre
Email: send email
Telefono: +39 0862 338324
Fax: +39 0862 338219

IT (MILANO) participant 100˙000.00
12    MERCK SERONO SA

 Organization address address: Chemin des Mines 9
city: GENEVE
postcode: 1202

contact info
Titolo: Mr.
Nome: Albert
Cognome: Pitteloud
Email: send email
Telefono: +41 22 739 3865
Fax: +41 22 739 3063

CH (GENEVE) participant 36˙963.00
13    DOMPE SPA

 Organization address address: Via Campo di Pile
city: L'Aquila
postcode: 67100

contact info
Titolo: Dr.
Nome: Cinzia
Cognome: D'ettorre
Email: send email
Telefono: +39 0862 338324
Fax: +39 0862 338219

IT (L'Aquila) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

pro    innovative    chronic    synthetic    inflammation    clinical    tlr    natural    leukocytes    resolving    strategies    activation    mechanisms    recruitment    leukocyte    microrna    resolution    drugs    diseases    autoimmune    resolve    chemokine    basis    shown    inflammatory    timer    molecules    endogenous    pathways    therapeutic    validate    receptors    cells   

 Obiettivo del progetto (Objective)

'Resolution of inflammation is a key determinant of pathology, and an active process which involves diverse pathways and molecules. The general objective of the TIMER Consortium is to identify and validate new molecules involved in the resolution of inflammation as a basis for the development of innovative therapeutic strategies in chronic inflammatory and autoimmune diseases. The project will involve discovery of new natural or synthetic “pro-resolving” molecules for plant and animals and investigation on endogenous inflammation “pro-resolving” mechanisms identified by various partners of the Consortium, including atypical chemokine receptors, decoy receptors, and microRNA. Tapping resources of natural compounds will be a major thrust. Efforts will be mainly focused on the regulation by “pro-resolving” agents on two molecular systems of key relevance in inflammation: the chemokine system, which regulates recruitment, permanence and egress of leukocyte in tissues; and the TLR/IL-1R system, which is central for the activation of infiltrating leukocytes. To this purpose, the project will capitalize on, and bring added value to a strong tradition of the Consortium in the fields of: leukocyte recruitment and activation; negative regulators of inflammation; industrial-academic collaboration; identification and characterization of innovative inhibitors of natural origin; European-Brazilian collaboration.'

Introduzione (Teaser)

Although inflammation is desirable to maintain health, the inability to resolve inflammatory responses can alter tissue homeostasis and cause disease. A group of European researchers is taking advantage of the physiological mechanisms that resolve inflammation to design drugs for treating chronic conditions.

Descrizione progetto (Article)

Inflammation is the complex response of our immune system to get rid of harmful stimuli, including pathogens.

Pathological chronic inflammation is known to be associated with many conditions including cancer, neurodegeneration and many autoimmune diseases.

The aim of the EU-funded 'Targeting novel mechanisms of resolution in inflammation' (http://www.eumbrella.org/timer.html (TIMER)) project is to identify and validate new molecules involved in the resolution of inflammation.

By focusing on the cells that sustain inflammation, the consortium hopes to provide the basis for the development of innovative therapeutic strategies.

The concept behind the TIMER study lies on the resolution of inflammation rather than on the passive blockade of pro-inflammatory mediators.

Through natural or synthetic 'pro-resolving' molecules, partners will target two key pathways of inflammation, namely the chemokine and the toll-like receptor (TLR) systems.

Chemokines work to attract leukocytes to sites of inflammation where they become activated by macrophages or dendritic cells through TLRs.

So far, researchers have unveiled three different mechanisms controlling inflammation.

The molecule TIR8 has been shown to promote the resolution of inflammation by blocking both chemokine and TLR pathways.

Resolution of inflammation has also been found to depend on microRNA molecules as well as on metabolic molecules.

Partners have worked on providing solutions to resolve inflammation in the form of synthetic or natural peptides and TLR-binding agonists.

Some of these have shown promising results in pre-clinical models and their efficacy is being further evaluated in a human clinical study.

By shedding light onto the mechanisms that resolve inflammation, the TIMER study proposes to use both endogenous and exogenous molecules that can regulate the inflammatory process.

The generated information could be exploited for the design of novel therapies and pro-resolving drugs that can alleviate the detrimental impact of chronic inflammation.

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