WINTHER

WINTHERapeutics: development of a systems biology method to predict efficacy of cancer drugs to optimize individualized therapeutic decision and improve clinical outcome for cancer patients

 Coordinatore INSTITUT GUSTAVE ROUSSY 

 Organization address address: Rue Camille Desmoulins 39
city: VILLEJUIF
postcode: 94805

contact info
Titolo: Mr.
Nome: Arnauld
Cognome: Forest
Email: send email
Telefono: 33142116604
Fax: 33142116160

 Nazionalità Coordinatore France [FR]
 Totale costo 4˙229˙837 €
 EC contributo 2˙998˙355 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2012-INNOVATION-1
 Funding Scheme CP-FP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-03-01   -   2015-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    INSTITUT GUSTAVE ROUSSY

 Organization address address: Rue Camille Desmoulins 39
city: VILLEJUIF
postcode: 94805

contact info
Titolo: Mr.
Nome: Arnauld
Cognome: Forest
Email: send email
Telefono: 33142116604
Fax: 33142116160

FR (VILLEJUIF) coordinator 991˙102.00
2    ARIANA PHARMACEUTICALS SA

 Organization address address: RUE DU DOCTEUR FINLAY 28
city: PARIS CEDEX
postcode: 75015

contact info
Titolo: Mrs.
Nome: Isabelle
Cognome: Chaduteau
Email: send email
Telefono: 33144371700

FR (PARIS CEDEX) participant 440˙496.00
3    FOUNDATION MEDICINE INC

 Organization address address: KENDALL SQUARE 1 SUITE B3501
city: CAMBRIDGE
postcode: 2139

contact info
Titolo: Dr.
Nome: Gary
Cognome: Palmer
Email: send email
Telefono: 446174000000

US (CAMBRIDGE) participant 368˙000.00
4    MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER

 Organization address address: TEL HASHOMER SHEBA MEDICAL CENTER
city: RAMAT GAN
postcode: 52621

contact info
Titolo: Mrs.
Nome: Aliza
Cognome: Ackerstein
Email: send email
Telefono: 97235307037
Fax: 97235304963

IL (RAMAT GAN) participant 315˙813.00
5    BEN-GURION UNIVERSITY OF THE NEGEV

 Organization address address: Office of the President - Main Campus
city: BEER SHEVA
postcode: 84105

contact info
Titolo: Ms.
Nome: Dori
Cognome: Schneider
Email: send email
Telefono: +972 8 6472435
Fax: +972 8 6472930

IL (BEER SHEVA) participant 306˙000.00
6    WORLDWIDE INNOVATIVE NETWORK ASSOCIATION

 Organization address address: RUE EDOUARD VAILLANT 114
city: VILLEJUIF
postcode: 94800

contact info
Titolo: Mrs.
Nome: Catherine
Cognome: Bresson
Email: send email
Telefono: 33142114020

FR (VILLEJUIF) participant 208˙620.00
7    Jewish General Hospital

 Organization address address: 3755 CHEMIN COTE SAINTE CATHERINE
city: MONTREAL QC
postcode: H3T 1E2

contact info
Titolo: Mr.
Nome: Gustavo
Cognome: Wendichansky
Email: send email
Telefono: 5143408222

CA (MONTREAL QC) participant 164˙794.00
8    FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON

 Organization address city: Barcelona
postcode: 8035

contact info
Titolo: Dr.
Nome: Alejandro
Cognome: Piris Gimenez
Email: send email
Telefono: +34 934 893 021

ES (Barcelona) participant 147˙952.00
9    THE UNIVERSITY OF TEXAS SYSTEM

 Organization address address: COLORADO STREET 601
city: AUSTIN
postcode: 78701 2982

contact info
Titolo: Mrs.
Nome: Ollieta
Cognome: Nicholas
Email: send email
Telefono: 17137924397
Fax: 17137924436

US (AUSTIN) participant 55˙578.00
10    STICHTING SAGE BIONETWORKS EU

 Organization address address: NOORDERAKERWEG 271 B
city: AMSTERDAM
postcode: 1069LT

contact info
Titolo: Dr.
Nome: Stephen H.
Cognome: Friend
Email: send email
Telefono: 12066673038

NL (AMSTERDAM) participant 0.00
11    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

 Organization address address: "FRANKLIN STREET 1111, 12 FLOOR"
city: OAKLAND CA
postcode: 94607

contact info
Nome: Sentelle
Cognome: Eubanks
Email: send email
Telefono: 18588225378

US (OAKLAND CA) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

tissue    patients    computational    efficacy    drug    genomic    benefit    tools    cancer    right    normal    therapies    tumour    drugs    trials    winther    database    clinical    matched    industry    algorithms    predict   

 Obiettivo del progetto (Objective)

'Relevance: WINTHER project focuses on the development and validation, in 24 months, of industry supported new tools and computational methods, to predict efficacy of drugs in cancer patients Current medical needs: Selection of cancer targeted therapies based on molecular abnormalities (mutations /amplifications/ translocations) benefit today only to 10-40% of patients. For the remaining majority, therapeutic decision is still based according to decade-old protocols with limited efficacy. Drug development depends on efficiency of clinical trials, with a staggering 95% failure rate

The objective: WINTHER proposes a fundamental change in trial design, through: 1. investigation of the tumour simultaneously with the normal matched tissue 2. development of a comprehensive database and genomic based algorithms and computational tools to predict the efficacy of drugs at individual level, in all patients, irrespective of cancer type 3. increase efficacy of therapeutics and clinical outcome,

Impact: Optimization of the portfolio of existing drugs and new compounds in clinical trials by matching the right drug to the right patient. In particular, it permits to avoid use of expensive drugs for patients that would not benefit from such treatments. WINTHER will made available to community as a clinically validated industry tool (website, database and algorithms) to assist clinicians in the analysis of genomic information based on the comparison of tumour and matched normal tissue and to increase the number of the patients to benefit from individualized rational selection of therapies.'

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