BRAINAGE

Impact of Prenatal Stress on BRAIN AGEing

Coordinatore	Universitätsklinikum Jena    more  Organization address city: Jena postcode: 7740 contact info Titolo: Prof. Nome: Matthias Cognome: Schwab Email: send email Telefono: +49 3641 9323486 Fax: +49 3641 9323412
Nazionalità Coordinatore	Germany [DE]
Sito del progetto	http://www.brain-age.eu/
Totale costo	3˙880˙676 €
EC contributo	2˙998˙420 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2011-two-stage
Funding Scheme	CP-FP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-03-01   -   2017-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	Nome Ente NON disponibile  Organization address city: Jena postcode: 7740 contact info Titolo: Prof. Nome: Matthias Cognome: Schwab Email: send email Telefono: +49 3641 9323486 Fax: +49 3641 9323412	DE (Jena)	coordinator	1˙076˙295.60
2	THE UNIVERSITY OF TEXAS SYSTEM  Organization address address: COLORADO STREET 601 city: AUSTIN postcode: 78701 2982 contact info Titolo: Mr. Nome: Chris Cognome: Green Email: send email Telefono: +01 210 567 2340 Fax: +01 210 567 2344	US (AUSTIN)	participant	372˙800.40
3	Academisch Medisch Centrum bij de Universiteit van Amsterdam  Organization address address: MEIBERGDREEF 9 city: AMSTERDAM postcode: 1105AZ contact info Nome: Salena Cognome: Voorneman Email: send email Telefono: +31 20 5667072 Fax: +31 20 5669698	NL (AMSTERDAM)	participant	355˙542.40
4	BIOCRATES LIFE SCIENCES AG  Organization address address: EDUARD BODEM GASSE 8 1 STOCK city: Innsbruck postcode: 6020 contact info Titolo: Dr. Nome: Denise Cognome: Sonntag Email: send email Telefono: 435126000000000 Fax: 435126000000000	AT (Innsbruck)	participant	303˙585.60
5	LEIBNIZ-INSTITUT FUR ALTERSFORSCHUNG - FRITZ-LIPMANN-INSTITUT E.V.  Organization address address: BEUTENBERGSTRASSE 11 city: JENA postcode: 7745 contact info Titolo: Ms. Nome: Babette Cognome: Scherneck Email: send email Telefono: +49 3641 656370 Fax: +49 3641 656351	DE (JENA)	participant	269˙544.00
6	STICHTING KATHOLIEKE UNIVERSITEIT BRABANT UNIVERSITEIT VAN TILBURG  Organization address address: Warandelaan 2 city: TILBURG postcode: 5037 AB contact info Titolo: Ms. Nome: Jane Cognome: Pinas Email: send email Telefono: +31 13 466 8064	NL (TILBURG)	participant	217˙279.20
7	UNIVERSITAET ULM  Organization address address: HELMHOLTZSTRASSE 16 city: ULM postcode: 89081 contact info Titolo: Mr. Nome: Jerg Cognome: Reiner Email: send email Telefono: +49 731 50 25066 Fax: +49 731 50 25064	DE (ULM)	participant	216˙144.00
8	LIFE LENGTH SL  Organization address address: CALLE AGUSTIN DE BETANCOURT 21 city: MADRID postcode: 28003 contact info Titolo: Mr. Nome: Stephen Cognome: Matlin Email: send email Telefono: 34913956368	ES (MADRID)	participant	115˙800.00
9	KATHOLIEKE UNIVERSITEIT LEUVEN  Organization address address: Oude Markt 13 city: LEUVEN postcode: 3000 contact info Titolo: Dr. Nome: Elke Cognome: Lammertyn Email: send email Telefono: +32 16 320621 Fax: +32 16 326515	BE (LEUVEN)	participant	71˙428.80

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 Obiettivo del progetto (Objective)

'Healthy brain ageing is a major determinant of quality life-long health, allowing integration into society at all ages. Human epidemiological and animal studies indicate that in addition to life style and genetic factors, environmental influences in prenatal life have a major impact on brain ageing and age-associated brain disorders. We hypothesize that: (1) prenatal stress programs early brain ageing; (2) this predisposes to age-associated brain diseases including cognitive decline and stroke; (3) epigenetic changes affecting glucocorticoid receptor (GR) sensitivity, altered autonomic nervous system (ANS) reactivity and cerebrovascular tone are important mediators of these processes, (4) these changes represent targets for diagnosis and therapeutic interventions. Our consortium has unique access to well-defined human and non-human primate cohorts (age range 25-115 y equivalents) that have been exposed to different types of prenatal stress. For experimental analysis of mechanisms of prenatal programming, we apply innovative techniques to characterize brain ageing, namely MRI based volumetry, non-linear analysis of EEG and ANS, advanced molecular techniques including epigenetics and metabolomics and neuropsychological and behavioral tests. Human subjects, non-human primates and rodents (including transgenic models) exposed to maternal stress, glucocorticoids or undernutrition are examined in order to: (1) determine structural (MRI based volumetry) and functional (metabolomics, brain function, cerebrovascular tone) indicators of brain age, (2) relate them to susceptibility to stroke and cognitive decline, (3) determine to what extent GR resistance, stress sensitivity, and cerebrovascular contractility mediate premature brain ageing and disease susceptibility; and, (4) dissect mechanisms and pharmacological interventions relevant for aged subjects. Data from the study allow to identify subjects at risk for premature brain ageing and to initiate interventional therapy.'