MOBODICT

Noninvasive Monitoring of Blood Flow and Oxygen Dynamics as Biomarkers in Cancer Tumours

Coordinatore	more  Organization address address: AVINGUDA CARL FRIEDRICH GAUSS 3 city: Castelldefels postcode: 8860 contact info Titolo: Ms. Nome: Dolors Cognome: Mateu Email: send email Telefono: 34935534053
Nazionalità Coordinatore	Non specificata
Totale costo	168˙896 €
EC contributo	168˙896 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-03-01   -   2014-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FUNDACIO INSTITUT DE CIENCIES FOTONIQUES  Organization address address: AVINGUDA CARL FRIEDRICH GAUSS 3 city: Castelldefels postcode: 8860 contact info Titolo: Ms. Nome: Dolors Cognome: Mateu Email: send email Telefono: 34935534053	ES (Castelldefels)	coordinator	168˙896.40

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 Obiettivo del progetto (Objective)

'Cancer is one of the leading causes of death in the world, taking an enormous toll on the society. Early detection is paramount for effective treatment. Afterwards, to individualize and optimize the treatment regime, it is increasingly becoming evident that early and frequent monitoring of the evolution of the tumour physiology in response to treatment is needed. Optical tools are emerging as promising modalities to this end. We will take advantage of this ability to carry out a pilot study to investigate the possibility of extending the use of diffuse optical methods to aid thyroid cancer characterization and therapy monitoring. Thyroid nodules are very common (~27% in adults) and a considerable amount of these, about 5%, develop into cancers. Unfortunately, the sensitivity and specificity of currently used technique for detection of potentially malignant nodules, thyroid ultrasound (US)-guided biopsies, is poor, making diagnosis and treatment difficult. We believe that optical methods will improve this. Furthermore, malignant tumours usually attract the formation of new and chaotic blood vessels via a complex process called angiogenesis. This has been exploited by the development of numerous treatment methods that rely on the inhibition of angiogenesis. However, it has also been observed that despite initial successful inhibition of angiogenesis, tumours may adapt and regain angiogenesis so that they can grow again. We will investigate this onset of tumour resistance by developing a novel, new 3D optical scanner for diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) in mouse models. If we are successful, we would advance the frontiers on basic understanding of cancer biology and explore new clinical applications of optical technologies.'

Introduzione (Teaser)

Control of the evolution of tumour physiology in response to treatment is necessary for successful therapy. Optical technologies are emerging as promising tools for early and frequent monitoring.