NEUROPROTEIN PROFILE

Large-scale protein expression profiling of genes implicated in cognitive disorders and dissection of their role in neural tissue development and plasticity

 Coordinatore MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. 

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Dr.
Nome: Birgit
Cognome: Knepper-Nicolai
Email: send email
Telefono: +49 351 2102772
Fax: +49 351 2101089

 Nazionalità Coordinatore Germany [DE]
 Totale costo 167˙390 €
 EC contributo 167˙390 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-04-01   -   2015-07-13

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Dr.
Nome: Birgit
Cognome: Knepper-Nicolai
Email: send email
Telefono: +49 351 2102772
Fax: +49 351 2101089

DE (MUENCHEN) coordinator 167˙390.40

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

expression    function    molecular    human    gene    neuronal    treatment    genes    adult    brain    cognitive    disease    disorders   

 Obiettivo del progetto (Objective)

Cognitive disorders are, due to their high frequency and lifelong costs, a leading medical and socio-economical problem world-wide. Particularly for the large number of disorders characterized by intellectual disability, no therapy is available. The search for effective treatment is unlikely to be successful until the pathology of these disorders is better understood. Currently mutations in around 300 human genes are known to cause cognitive disorders. These genes provide an exciting molecular window into fundamental neuroscience and translational research. In 2010, a large international project, FP7 GENCODYS, has been started to characterize their function on the large scale. An early outcome of this project is a systematic library of Drosophila strains that express the fly homologs of human cognitive disorder disease genes as fluorescently tagged (and thus easily traceable) proteins, under their endogenous genomic regulatory control. Combining this novel native reporter toolbox with modern microscopy techniques I propose to create and assemble high-resolution 3D maps of gene expression profiles of these genes in the nervous tissue during embryonic development and in the adult brains of fruitflies, the two conditions most relevant to their associated human disease pathologies. Adult gene expression patterns will be generated under both the steady-state and the stimulated brain activity conditions in order to uncover key factors of neuronal plasticity. We expect these unique charts of plastic neuronal activity to significantly contribute to our understanding of higher brain function in health and disease. They will also facilitate the identification of common molecular pathways that can be targeted for effective treatment of cognitive disorders.

Altri progetti dello stesso programma (FP7-PEOPLE)

NANOTOX (2011)

"Nanoparticle - Cell Interactions, a Pathway for Understanding Nanotoxicity: from a Model System to in-vitro System."

Read More  

RTSAPA (2013)

The role of Toll-Like Receptors Signaling in Angiogenesis and its Potential Applications in Promoting Vascularization in Regenerative Medicine

Read More  

POLYMEIO (2014)

The Role of ASY1 in Promoting Meiotic Stability in Polyploid Arabidopsis

Read More