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GEMiNI SIGNED

A genetic model for neurorehabilitation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "GEMiNI" data sheet

The following table provides information about the project.

Coordinator
FACULDADE DE CIENCIAS MEDICAS DA UNIVERSIDADE NOVA DE LISBOA 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country Portugal [PT]
 Total cost 160˙635 €
 EC max contribution 160˙635 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) coordinator 160˙635.00
2    FACULDADE DE CIENCIAS MEDICAS DA UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) coordinator 0.00

Map

 Project objective

Coordinated walking in vertebrates and multi-legged invertebrates such as the fruit fly Drosophila melanogaster is controlled by an evolutionarily conserved network capable to control movement in a fast, stable, and energy-efficient way. At the same time, it provides the flexibility to adapt to changes in the terrain, load, and internal motor representations due to disease or injury. Currently, the contribution of different brain structures responsible for the recovery process is only partially understood and, importantly, the role of specific genes remains mostly elusive. Preliminary data shows that adult Drosophila flies in which the two middle legs were amputated improve their gait performance gradually over the course of a few days engaging in a more controlled gait. We also find that mutants for the learning and memory gene rutabaga lack any kind of short- or long-term recovery. These results suggest that flies can readjust their motor circuitry upon injury and that a mechanism of synaptic plasticity might be involved. The overall goal of this proposal is to establish the fruit fly Drosophila as a genetic model for neurorehabilitation and recovery after amputation, which will allow the identification of new genes and mechanisms of motor plasticity. In order to carry out these aims, I will take advantage of the sophisticated Drosophila neurogenetic toolkit that allows gene manipulation and the execution of in vivo gain and loss-of-function experiments in a controlled number of neurons. In addition, I will use an adult fly walking assay that I developed during my postdoc, the FlyWalker system, which allows a detailed quantification of locomotor activity. Identifying genes and molecular components that affect the process of plasticity and motor adaptation will allow us to identify new biochemical pathways that influence the recovery process and design new approaches to enhance recovery outcomes.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GEMINI" project.

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Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GEMINI" are provided by the European Opendata Portal: CORDIS opendata.

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