BIOTRACHEA

Biomaterials for Tracheal Replacement in Age-related Cancer via a Humanly Engineered Airway

 Coordinatore KAROLINSKA INSTITUTET 

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Ms.
Nome: Ylva
Cognome: Hultman
Email: send email
Telefono: +46 8 524 865 02

 Nazionalità Coordinatore Sweden [SE]
 Totale costo 5˙464˙792 €
 EC contributo 3˙999˙300 €
 Programma FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
 Code Call FP7-NMP-2011-SMALL-5
 Funding Scheme CP-FP
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-04-01   -   2017-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Ms.
Nome: Ylva
Cognome: Hultman
Email: send email
Telefono: +46 8 524 865 02

SE (STOCKHOLM) coordinator 1˙173˙842.00
2    UNIVERSITY COLLEGE LONDON

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Ms.
Nome: Greta
Cognome: Borg-Carbott
Email: send email
Telefono: +44 2031083033
Fax: +44 2078132849

UK (LONDON) participant 695˙800.00
3    UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA

 Organization address address: VIA UNIVERSITA 4
city: MODENA
postcode: 41100

contact info
Titolo: Prof.
Nome: Graziella
Cognome: Pellegrini
Email: send email
Telefono: +39 059 2058064
Fax: +39 059 2058115

IT (MODENA) participant 400˙750.00
4    IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

 Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ

contact info
Titolo: Dr.
Nome: Tatjana
Cognome: Palalic
Email: send email
Telefono: +44 020 7594 3866
Fax: +44 020 7594 3860

UK (LONDON) participant 366˙000.00
5    HUGO SACHS ELEKTRONIK - HARVARD APPARATUS GMBH

 Organization address address: GRUNSTRASSE 1
city: MARCH HUGSTETTEN
postcode: 79232

contact info
Titolo: Dr.
Nome: Roger
Cognome: Zink
Email: send email
Telefono: +49 7665920024

DE (MARCH HUGSTETTEN) participant 289˙200.00
6    CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI

 Organization address address: Via Giusti 9
city: FIRENZE
postcode: 50121

contact info
Titolo: Mr.
Nome: Daniele
Cognome: Consigli
Email: send email
Telefono: +39 055 233871
Fax: +39 055 2480111

IT (FIRENZE) participant 208˙800.00
7    CONSIGLIO NAZIONALE DELLE RICERCHE

 Organization address address: Piazzale Aldo Moro 7
city: ROMA
postcode: 185

contact info
Titolo: Dr.
Nome: Loredana
Cognome: De Bartolo
Email: send email
Telefono: +39 0984 492036
Fax: +39 0984 402103

IT (ROMA) participant 205˙428.00
8    INTERCYTEX LTD

 Organization address address: CREWE ROAD INNOVATION HOUSE
city: MANCHESTER
postcode: M23 9QR

contact info
Titolo: Ms.
Nome: Paula
Cognome: Thompson
Email: send email
Telefono: +44 161 606 7204

UK (MANCHESTER) participant 192˙000.00
9    UNIVERSITAET LEIPZIG

 Organization address address: RITTERSTRASSE 26
city: LEIPZIG
postcode: 4109

contact info
Titolo: Dr.
Nome: Doris
Cognome: Stefanowa
Email: send email
Telefono: +49 341 97 31350
Fax: +49 341 97 31359

DE (LEIPZIG) participant 181˙680.00
10    Pharmidex Pharmaceutical Services Limited

 Organization address address: HANOVER STREET 14 FLOOR 3
city: LONDON
postcode: W1S 1RR

contact info
Titolo: Dr.
Nome: Mo
Cognome: Alavijeh
Email: send email
Telefono: +44 0 870 240 5978
Fax: +44 0 845 1259586

UK (LONDON) participant 124˙500.00
11    INSTITUT GUSTAVE ROUSSY

 Organization address address: Rue Camille Desmoulins 39
city: VILLEJUIF
postcode: 94805

contact info
Titolo: Dr.
Nome: Arnauld
Cognome: Forest
Email: send email
Telefono: +33 142116604

FR (VILLEJUIF) participant 80˙400.00
12    ROBERT KOCH-INSTITUT

 Organization address address: Nordufer 20
city: Berlin
postcode: 13353

contact info
Titolo: Ms.
Nome: Birgit
Cognome: Arnold
Email: send email
Telefono: +49 30 18754 2680
Fax: +49 30 18754 2117

DE (Berlin) participant 60˙000.00
13    AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI

 Organization address address: via delle Oblate 1
city: FIRENZE
postcode: 50139

contact info
Titolo: Prof.
Nome: Paolo
Cognome: Macchiarini
Email: send email
Telefono: +39 055 79496099
Fax: +39 055 79499874

IT (FIRENZE) participant 20˙900.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

technique    age    successful    vivo    inoperable    cancer    cancers    tracheal    otherwise    outcome    tissue    patients    related    thousands    human    clinical    lesions    trachea   

 Obiettivo del progetto (Objective)

'Age-related cancers, especially of the trachea, are neoplastic lesions that significantly impact upon the lives of thousands of European patients each year. Unfortunately, most present with inoperable lesions for which median survival is less than 12 months. Based on our previous clinically successful experiences with in vivo completely tissue engineered tracheal replacement in benign tracheal diseases, we recently applied this technology in 2 patients with otherwise inoperable primary tracheal cancers. The successful observed outcome confirms the unique opportunity to scale-up an effective therapeutic approach into a widely accessible clinical technology, which could enhance not only the quality of life but even cure otherwise untreatable patients. However, a limitation of our current technology is the time it takes to re-populate the decellularized trachea. This may prove critical in the case of cancer patients. Further, the size of the transplant is currently limited due to the fact that the transplanted tissue needs to be efficiently and rapidly vascularised to prevent necrosis in vivo. To surmount these limitations, we aim to: i) improve our current technique of in vivo tissue engineering human tracheae in a small number of patients and subsequently begin a formal clinical trial, ii) develop pharmacological approaches to activate endogenous stem cells, stimulate tissue regeneration and vascularisation in situ, iii) develop a synthetic tracheal scaffold using a novel nanocomposite polymer as alternatives to natural human scaffolds and iv) develop good medical practice manufacturing process for safe, efficient and cost effective commercial production. This research project is aimed to define a robust airway implantation technique assuring a better outcome for thousands of patients each year. Moreover, we aim to use these results as a starting point to develop clinical approaches that could improve the treatment of age-related cancers of other hollow organs.'

Introduzione (Teaser)

The outcome for patients with tracheal cancer will be radically transformed with the development of tracheal replacements made from biosynthetic materials.

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