CARDIOMICROBIOME

Discovery of Atherosclerosis Microbiome: Systems Biology of Cardiovascular Pathogenesis

 Coordinatore CONSORCI INSTITUT CATALÀ DE CIÈNCIES CARDIOVASCULARS 

 Organization address address: Av. Sant Antoni M. Claret 167
city: Barcelona
postcode: 8025

contact info
Titolo: Mr.
Nome: Escobar
Cognome: Joaquim
Email: send email
Telefono: +34 93 556 56 10
Fax: +34 93 556 55 59

 Nazionalità Coordinatore Spain [ES]
 Totale costo 226˙548 €
 EC contributo 226˙548 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-IIF
 Funding Scheme MC-IIF
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-06-04   -   2014-06-03

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    Nome Ente NON disponibile

 Organization address address: Av. Sant Antoni M. Claret 167
city: Barcelona
postcode: 8025

contact info
Titolo: Mr.
Nome: Escobar
Cognome: Joaquim
Email: send email
Telefono: +34 93 556 56 10
Fax: +34 93 556 55 59

ES (Barcelona) coordinator 226˙548.40

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

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 Obiettivo del progetto (Objective)

'The target for this project is a novel approach addressing the infectious component of atherosclerosis, a disease which leads to myocardial infarction and stroke. Using immunology, cellular microbiology, genomics/metagenomics and fluorescence microscopy, our multidisciplinary team was the first to demonstrate vascular cell transmission of bacterial pathogens, the first to show association of dormant invasive bacteria with atheromatous tissue and, most importantly, the first to develop a technology to isolate and identify previously uncultivable bacterial pathogens from such tissues from patients.

The objectives of this innovative proposal are to describe for the first time a critical for public health segment of the human microbiome, the atherosclerosis microbiome, to cultivate and identify its members and to determine the prevalence of these species in patients’ tissues. Further, we will examine the physiological capability of the pathogens to modulate 1) the lipid metabolism, 2) the pro-inflammatory response and 3) the viability of atheromatous tissue resident cell types, human phagocytic, endothelial and smooth muscle cells (SMCs). This will allow us to reveal the functional significance of the members of the atherosclerotic microbiome that may be critical for atherogenesis.

This proposal builds on the excellence in the field of atherosclerosis research of the ICCC and of the Columbia University Medical Center in New York City. The deliverables of this project include much-awaited clarification of an entirely novel risk factor for atherogenesis that will benefit the majority of the EU population, at risk of number one cause of death. This focused project will define entirely novel targets for theragnostic clinical developments in the critical area of cardiovascular disease. Notably, bacterial infections can be a modifiable risk factor, making the accomplishment of this project a significant advancement, opening a new field in vascular medicine.'

Introduzione (Teaser)

The mouth is teeming with bacteria, most of them harmless. However, EU-funded scientists have shown that they often find their way to the arteries, remaining dormant until some trigger causes them to play a role in heart attack.

Descrizione progetto (Article)

The Consorci Institut Catala de Ciencies Cardiovasculars (ICCC) in Spain was among the first to demonstrate an association between dormant invasive bacteria and degenerative tissue on artery walls. ICCC scientists also developed a method to isolate and cultivate bacterial pathogens from patient tissue for the first time.

The group recently completed work on an EU-funded study of patients undergoing surgery for arterial obstruction. The results of the project 'Discovery of atherosclerosis microbiome: Systems biology of cardiovascular pathogenesis' (CARDIOMICROBIOME) point to a different microbial environment in atherosclerotic tissue compared to that in healthy vascular tissue. This may partially explain why atherosclerosis does not always follow the patient profile associated with hypertension, hyperlipidaemia, diabetes and smoking.

In particular, using advanced molecular probes it was shown for the first time that within the same individual, there was a higher presence of bacterial species compared to a similar sample of healthy tissue. These bacteria are known to induce clotting of the blood. This points to a model where, unlike in the mouth, the bacteria in the arteries go relatively unnoticed for a long period of time, causing chronic low-grade inflammation. At some point, an as yet unclear trigger causes them to play a role in heart attack or stroke.

The data also support previous results from the same research group showing periodontal bacteria in the carotid arteries, the large arteries in the neck that carry blood from the heart to the brain. This provides a potential link between oral hygiene and brain-related diseases such as ischemic stroke and neurodegenerative conditions that requires further investigation.

CARDIOMICROBIOME results are important for a number of reasons. The link between oral hygiene and cardiovascular health provides a straightforward route to prevention of cardiovascular diseases through improved tooth and gum care. Identification of the bacteria present in the arterial plaques opens the door to use of antibiotics to treat atherosclerosis. Finally, demonstration of bacterial species from the mouth in the blood highlights the possibility of those bacteria setting up house virtually anywhere in the body.

The project has answered significant questions and, as all good research should, identified new ones and the direction of future studies. Practically, the potential benefits to health care costs and patient morbidity cannot be underestimated.

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