CBTOUCH

The cerebellar control of motor tuning during sensory discrimination

Coordinatore	ECOLE NORMALE SUPERIEURE    more  Organization address address: "45, RUE D'ULM" city: PARIS CEDEX 05 postcode: 75230 contact info Titolo: Ms. Nome: Anne Cognome: Cormier Email: send email Telefono: +33 1 44 32 33 20 Fax: +33 1 44 32 38 47
Nazionalità Coordinatore	France [FR]
Totale costo	193˙594 €
EC contributo	193˙594 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IEF
Funding Scheme	MC-IEF
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-06-01   -   2014-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ECOLE NORMALE SUPERIEURE  Organization address address: "45, RUE D'ULM" city: PARIS CEDEX 05 postcode: 75230 contact info Titolo: Ms. Nome: Anne Cognome: Cormier Email: send email Telefono: +33 1 44 32 33 20 Fax: +33 1 44 32 38 47	FR (PARIS CEDEX 05)	coordinator	193˙594.80

Mappa

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 Obiettivo del progetto (Objective)

'The CBTOUCH project focuses on the cerebellum as a crucial component of the circuit involved in the precise tuning of motor control during tactile discrimination. A large fraction of the tactile information is acquired in a motor context.The nervous system must thus combine the sensory and motor informations to optimize movements aimed at collecting information and ultimately correctly interpret the sensations. My project aims at exploring the neurobiological basis of these operations, and particularly to identify the contribution of the cerebellum. Specifically, I will study the whisker sensory system in the rodent. The aims of my project are to: 1.identify the connections of the cerebellum with the whisker sensory-motor cortices thanks to a combination of functional imaging optogenetic and electrophysiological experiments. 2.demonstrate the functional recruitment of the cerebellum in relation with the whiskers movements during tactile exploration of known and unknown stimuli configurations, using electrophysiological recordings and fast video recordings in awake animals. 3.establish the contribution of the cerebellum to the sense of touch by perturbing the cerebellar function during sensory discrimination, using optogenetic stimulations during a behavioral task This project should help to understand how the body movements are precisely tuned to optimize the sense of touch.'

Introduzione (Teaser)

Several diseases, such as stroke, Huntington's and Parkinson's diseases, schizophrenia and autism, are all connected to abnormal sensorimotor integration. A better understanding of the circuitry involved in sensorimotor cooperation has been obtained in a study using rodents.