ARTHEROSPACE

Arthero-Space project: A model based exploration of the regulatory mechanism of the microcirculation for the prevention of orthostatic intolerance

 Coordinatore DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV 

 Organization address address: Linder Hoehe
city: KOELN
postcode: 51147

contact info
Titolo: Ms.
Nome: Uliana
Cognome: Eckler
Email: send email
Telefono: +49 2203 601 4212
Fax: +49 2203 601 2893

 Nazionalità Coordinatore Germany [DE]
 Totale costo 221˙718 €
 EC contributo 221˙718 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-IOF
 Funding Scheme MC-IOF
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-09-01   -   2015-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV

 Organization address address: Linder Hoehe
city: KOELN
postcode: 51147

contact info
Titolo: Ms.
Nome: Uliana
Cognome: Eckler
Email: send email
Telefono: +49 2203 601 4212
Fax: +49 2203 601 2893

DE (KOELN) coordinator 221˙718.60

Mappa


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combining    hydrostatic    physiology    blood    responses    model    quadratic    me    programs    cardiovascular    peripheral    propagation    mechanisms    vivo    wave    experiments    linear    data    earth    crucial    pressure    space    loads    protocols    astronaut   

 Obiettivo del progetto (Objective)

'Orthostatic intolerance remains a problem upon return to Earth from the microgravity environment of spaceflight. To improve astronaut's countermeasure programs, a better understanding of the response of the cardiovascular system to changes in hydrostatic pressure is crucial. My objective is to assess the regulatory mechanisms of the microcirculation in response to hydrostatic pressure by combining in vivo experiments and 1D blood pressure wave propagation model. At the Aerospace Physiology Laboratory of SFU, I will perform in vivo experiments using a tilt table and a Low Body Negative Pressure set-up to generate a step and linear increases in the hydrostatic pressure. Quadratic increases in hydrostatic pressure will be generated with a Short Arm Human Centrifuge at the Space Physiology division of the DLR. Combining these three protocols will allow me to differentiate responses to abnormal hydrostatic loads (step and quadratic increases) from a linear gradient in hydrostatic pressure normally felt on earth. High resolution ultrasound imaging techniques will be used to measure hemodynamical parameters of large vessels. Concurrently, the theoritical effects of hydrostatic pressure will be implemented in a 1D wave propagation model of blood flow and pressure to simulate the cardiovascular response to the in vivo protocols described above. Furthermore, a fitting process between in-vivo data and simulated data will provide physiological parameters describing the specific vasoconstriction responses of the peripheral bed to the different hydrostqtic loads. The results of this project will bring new insights into the response of the cardiovascular system to changes in hydrostatic pressure which are essential to improve astronaut's training programs and resolve crucial issues in hypotension and peripheral vascular diseases. This project will enable me to make an important step towards my career objective to become an established researcher in the field of space physiology.'

Introduzione (Teaser)

The cardiovascular system relies on a complex synergy of control mechanisms to maintain blood pressure and cerebral perfusion, but the system malfunctions during astronauts' re-entry from space. New studies of mechanisms will improve countermeasures.

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