HETEROGENIUS

Heterogeneous activity underlying the control of animal behaviour by a fungus

 Coordinatore LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Mr.
Nome: Frank
Cognome: Spiekermann
Email: send email
Telefono: 498922000000
Fax: 498922000000

 Nazionalità Coordinatore Germany [DE]
 Totale costo 266˙289 €
 EC contributo 266˙289 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-IOF
 Funding Scheme MC-IOF
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-08-16   -   2015-08-15

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Mr.
Nome: Frank
Cognome: Spiekermann
Email: send email
Telefono: 498922000000
Fax: 498922000000

DE (MUENCHEN) coordinator 266˙289.00

Mappa


 Word cloud

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hypothesis    host    ant    manipulation    circadian    parts    combine    elucidate    cells    transcriptome    heterogeneous    fungus    fungal    parasite   

 Obiettivo del progetto (Objective)

'One of the most dramatic examples of parasites controlling behaviour is the manipulation of ants infected by the fungus Ophiocordyceps unilateralis, causing them to bite into vegetation before dying. Most work so far has described the ant’s behaviour. I plan to study the process behind this behaviour from the fungal genome point of view. The environment experienced by the fungal parasite changes dramatically as it goes from infection to manipulation. Therefore, the transcriptome of this mind controlling fungus is expected to be highly heterogeneous. To test this hypothesis and elucidate the complex genetic mechanisms behind adaptive parasite manipulation of host behaviour I will use a single cell, whole transcriptome analysis protocol I pioneered and apply it to this emerging model. This will allow me to sample cells in different parts of the ant’s body during different phases of the lifecycle. I will combine this with LC/MS in fungal cells transferred between artificial ant environments to elucidate the fungal metabolites that are secreted in different parts within the host. Recently, it has been discovered that manipulated biting behaviour is synchronized at noon. This indicates that the fungal circadian clock might have a big influence on this parasitic behavioural control. Therefore, I will combine my findings with chronobiology to test the hypothesis if this heterogeneous activity is a function of circadian rhythm. An important additional objective of this proposal is advanced training facilitating my transition to independence.'

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