NANODEM

NANOphotonic DEvice for Multiple therapeutic drug monitoring

 Coordinatore CONSIGLIO NAZIONALE DELLE RICERCHE 

 Organization address address: Via Madonna del Piano 10
city: Sesto Fiorentino-Firenze
postcode: 50019

contact info
Titolo: Mr.
Nome: Paolo
Cognome: Di Maggio
Email: send email
Telefono: +39 055 5226491
Fax: +39 055 5226400

 Nazionalità Coordinatore Italy [IT]
 Totale costo 5˙285˙964 €
 EC contributo 3˙983˙000 €
 Programma FP7-ICT
Specific Programme "Cooperation": Information and communication technologies
 Code Call FP7-ICT-2011-8
 Funding Scheme CP
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-10-01   -   2016-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE

 Organization address address: Via Madonna del Piano 10
city: Sesto Fiorentino-Firenze
postcode: 50019

contact info
Titolo: Mr.
Nome: Paolo
Cognome: Di Maggio
Email: send email
Telefono: +39 055 5226491
Fax: +39 055 5226400

IT (Sesto Fiorentino-Firenze) coordinator 0.00
2    DATAMED SRL

 Organization address address: VIA PAPA GIOVANNI XXIII
city: RODANO (MI)
postcode: 20090

contact info
Titolo: Mr.
Nome: Giampiero
Cognome: Porro
Email: send email
Telefono: +39 2 95327090
Fax: +39 2 95327089

IT (RODANO (MI)) participant 0.00
3    EBERHARD KARLS UNIVERSITAET TUEBINGEN

 Organization address address: GESCHWISTER-SCHOLL-PLATZ
city: TUEBINGEN
postcode: 72074

contact info
Titolo: Prof.
Nome: Guenter
Cognome: Gauglitz
Email: send email
Telefono: +49 7071 2976927
Fax: +49 7071 295772

DE (TUEBINGEN) participant 0.00
4    INESC MICROSISTEMAS E NANOTECNOLGIAS-INSTITUTO DE ENGENHARIA DE SISTEMAS DE COMPUTADORES PARA OS MICROSISTEMAS E AS NANOTECNOLOGIAS

 Organization address address: Rua Alves Redol
city: LISBOA
postcode: 1000-029

contact info
Titolo: Mrs.
Nome: Ilda
Cognome: Ribeiro
Email: send email
Telefono: +351 21 3100424
Fax: +351 21 3100425

PT (LISBOA) participant 0.00
5    KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

 Organization address address: ISMANINGER STRASSE
city: MUENCHEN
postcode: 81675

contact info
Titolo: Ms.
Nome: Beate
Cognome: Schaulin
Email: send email
Telefono: +49 89 41402856
Fax: +49 89 41404926

DE (MUENCHEN) participant 0.00
6    MICROFLUIDIC CHIPSHOP GMBH

 Organization address address: STOCKHOLMER STRASSE
city: JENA
postcode: 7747

contact info
Titolo: Dr.
Nome: Holger
Cognome: Becker
Email: send email
Telefono: +49 3641 347050

DE (JENA) participant 0.00
7    Probe Scientific Ltd

 Organization address address: Sir Williams Lyons Road
city: Coventry
postcode: CV4 7EZ

contact info
Titolo: Dr.
Nome: Mark
Cognome: O'Connell
Email: send email
Telefono: +44 24 7632 3049

UK (Coventry) participant 0.00
8    UNIVERSIDAD COMPLUTENSE DE MADRID

 Organization address address: AVENIDA SENECA 2 EDIFICIO SENECA
city: MADRID
postcode: 28040

contact info
Titolo: Ms.
Nome: Maribel
Cognome: RODRIGUEZ VILLA
Email: send email
Telefono: +34 913946376
Fax: +34 913946382

ES (MADRID) participant 0.00
9    UNIVERSITAET STUTTGART

 Organization address address: Keplerstrasse
city: STUTTGART
postcode: 70174

contact info
Titolo: Dr.
Nome: Markus B.
Cognome: Schubert
Email: send email
Telefono: 4971170000000
Fax: 4971170000000

DE (STUTTGART) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

device    analytes    therapeutic    drugs    chip    optical    micro    sections    poct    microdialysis    detection    intervals    reagents    convergence    related    time    metabolites    dialysate    drug   

 Obiettivo del progetto (Objective)

Project aim is the development of a novel therapeutic drug monitoring point-of-care-testing (POCT) device for the measurement of immunosuppressants and related metabolites in transplanted patients. The new device will allow the automatic measurements of therapeutic drugs and metabolites characterized by a narrow therapeutic range and serious potential side effects. Clinical benefit will be an optimized dosage of the respective therapeutical drug. The patient will be connected to the device by an intravenous microdialysis catheter to allow 48-h online measurements. Based on this minimally-invasive approach, the therapeutic drugs and related metabolites will be monitored at short time intervals. The need of mixing the dialysate with the chemical reagents and the necessity of incubation times for the bioassay implementation, unavoidable procedure for bioanalyte detection, implies that a continuous measurement of such analytes is impossible, but the miniaturisation down to micro- and nano-scales will lead to very short time intervals, of the order of a few minutes. Heart of the device will be a multi-parametric optical chip, which will make use of the recent developments in nanotechnology to convert the concentration changes of the analytes in detectable luminescent signals. Essential sections of the device will be also:ni) the microfluidic circuit before the chip, where the dialysate is mixed with the reagents necessary for the implementation of the biological assay;nii) the optical detection system which must be characterised by high efficiency and strong compactness;niii) the compact hardware control unit and user interface that allow instrument control and data handling.nThe integration of all these sections within the POCT stand-alone device requires the convergence of competences ranging from chemistry and biochemistry to optics and medicine as well as the convergence of micro and nanotechnologies, such as micro/nanofluidics,microdialysis and micro/nanosensing.

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