small RNA mediated heterochromatin formation in fission yeast


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 Nazionalità Coordinatore Germany [DE]
 Totale costo 1˙500˙000 €
 EC contributo 1˙500˙000 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2012-StG_20111109
 Funding Scheme ERC-SG
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-11-01   -   2017-10-31


# participant  country  role  EC contrib. [€] 

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
postcode: 80539

contact info
Titolo: Mr.
Nome: Steven
Cognome: Daskalov
Email: send email
Telefono: +49 89 21803 6941
Fax: +49 89 2180 2985

DE (MUENCHEN) hostInstitution 1˙500˙000.00

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
postcode: 80539

contact info
Titolo: Prof.
Nome: Mario
Cognome: Halic
Email: send email
Telefono: +49 89 2180 76903

DE (MUENCHEN) hostInstitution 1˙500˙000.00


 Word cloud

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rnas    rnai    repetitive    genome    heterochromatin    cells    determine    biogenesis    prirnas    rna    regulation    small    gene    expression   

 Obiettivo del progetto (Objective)

'Regulation of genome expression is essential for cell proliferation, differentiation, development and viability. Small RNA silencing pathways are involved in the cellular control of gene expression and in protection of the genome against mobile repetitive DNA sequences, retroelements and transposons. Small RNAs interact with target RNAs and promote chromatin modifications, translational inhibition or degradation of complementary RNAs. We have uncovered new class of small RNAs in fission yeast, priRNAs, which are generated independently of Dicer. priRNAs are likely to be involved in triggering of siRNA amplification and heterochromatin assembly within centromeric repeats. In first aim, using small RNA sequencing and transcriptomic approaches, combined with biochemistry and functional assays, we will determine biogenesis and function of noncentromeric priRNAs. Specifically, Argonaute-dependent 3' end formation of priRNAs will be studied, a process conserved in piRNA biogenesis in higher eukaryotes. In second aim, we will study what recruits RNAi to transposable and repetitive elements. Furthermore, we will study RNA susceptibility to RNA interference. In third aim, we will use cryo electron microscopy to determine structure of chromodomain protein Chp1 bound to nucleosomes with histone 3 lysine 9 methylated. We will extend this study on other RNAi and heterochromatin complexes. Defects in small RNA-mediated regulation of genome expression have been described in several human cancers. Fundamental understanding of the role of small RNAs in gene regulation will help us understand why some cells loose their identity and turn into cancer cells.'

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