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MCNANO SIGNED

“Multi-component nanoparticles as bimodal contrast agents for MRI and optical detection of tumors and for targeted photodynamic therapy”

Total Cost €

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EC-Contrib. €

0

Partnership

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 MCNANO project word cloud

Explore the words cloud of the MCNANO project. It provides you a very rough idea of what is the project "MCNANO" about.

water    ions    optical    photoactivated    region    contrast    ho3    lanthanide    n3    ultimately    chemistry    excitation    acid    imaging    cholesterol    suitable    tumor    modular    express    disruptive    cure    nanomatrix    tissues    mri    efficacy    offers    rgd    cells    emission    degree    clinical    decorated    functionalization    biocompatible    drug    nh2    area    upconverting    photo    bimodal    nanoparticles    receptors    fluoride    anti    dy3    covered    bio    tm3    infrared    visible    will    tb3    agents    oh    treatment    core    efficient    soluble    upconverted    er3    active    light    blue    components    synthesis    surface    exhibit    detection    therapeutic    first    cancer    nanoparticle    attaching    t2    combination    multidisciplinary    emitted    of    time    rare    nanoprobes    containing    photoluminescence    spectroscopy    shell    synthesize    980    excited    platform    yield    strategies    earth    pt    nano    diagnosis    simultaneously    agent    cyclic    combines    moieties    py    folic    simultaneous    anchoring    doped    phototheranostic   

Project "MCNANO" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201801815
 Total cost 172˙800 €
 EC max contribution 172˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 172˙800.00

Map

 Project objective

The main aim of this proposal is to synthesize a range of lanthanide containing nanoparticles with an upconverting core, that can be excited in the infrared region to yield emission in the visible range, as for MRI and optical imaging. The nanoparticles will be covered with a rare earth doped MRI active shell and decorated with targeting moieties, which offers a means of targeting cancer cells that greatly over express the receptors. Further we will develop “phototheranostic” agents by anchoring the photo active anti cancer drug in between the receptors and the surface of upconverting/MRI active nanoparticle. A platform for synthesis of water soluble, modular target specific bimodal agents based on nanoprobes will be developed that will exhibit efficient upconverted photoluminescence from the rare-earth ions (Er3/Tm3) doped into fluoride nanomatrix. Simultaneously, the Tb3/Dy3/Ho3 present at the shell will make them suitable as T2 contrast agents for MRI. Specific tumor targeting strategies will be developed by attaching targeting components like folic acid, cholesterol or cyclic-RGD to the surface of the nanoparticles. Functionalization of nanoparticles with [Pt(N3)2(OH)2(NH2-R)(py)] drug, which can be photoactivated by the blue light emitted from the nanoparticle core upon excitation at 980, will result in a novel phototheranostic anti-cancer agent. This system may allow a large degree of control of the therapeutic efficacy and ultimately lead to simultaneous diagnosis and treatment in clinical applications. The unique multidisciplinary approach adopted here which combines areas of nano-chemistry, spectroscopy and bio-imaging, is expected to lead to a disruptive change in the area of cancer research. The combination of these areas would allow for the first time the development of biocompatible “phototheranostic” agents for the simultaneous detection by MRI/optical imaging and cure of the cancer- affected tissues.

 Publications

year authors and title journal last update
List of publications.
2018 Silvanose Biju, Juan Gallo, M. Bañobre-López, Bella B. Manshian, Stefaan J. Soenen, Uwe Himmelreich, Luce Vander Elst, Tatjana N. Parac-Vogt
A Magnetic Chameleon: Biocompatible Lanthanide Fluoride Nanoparticles with Magnetic Field Dependent Tunable Contrast Properties as a Versatile Contrast Agent for Low to Ultrahigh Field MRI and Optical Imaging in Biological Window
published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201801814
Chemistry - A European Journal 2019-06-13
2018 Silvanose Biju, Tatjana Parac-Vogt
Recent Advances in Lanthanide Based Nano-architectures as Probes for Ultra High-Field Magnetic Resonance Imaging
published pages: , ISSN: 0929-8673, DOI: 10.2174/0929867325666180201110244
Current Medicinal Chemistry 25 2019-06-13

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