Explore the words cloud of the MCNANO project. It provides you a very rough idea of what is the project "MCNANO" about.
The following table provides information about the project.
KATHOLIEKE UNIVERSITEIT LEUVEN
|Coordinator Country||Belgium [BE]|
|Total cost||172˙800 €|
|EC max contribution||172˙800 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-04-01 to 2018-03-31|
Take a look of project's partnership.
|1||KATHOLIEKE UNIVERSITEIT LEUVEN||BE (LEUVEN)||coordinator||172˙800.00|
The main aim of this proposal is to synthesize a range of lanthanide containing nanoparticles with an upconverting core, that can be excited in the infrared region to yield emission in the visible range, as for MRI and optical imaging. The nanoparticles will be covered with a rare earth doped MRI active shell and decorated with targeting moieties, which offers a means of targeting cancer cells that greatly over express the receptors. Further we will develop “phototheranostic” agents by anchoring the photo active anti cancer drug in between the receptors and the surface of upconverting/MRI active nanoparticle. A platform for synthesis of water soluble, modular target specific bimodal agents based on nanoprobes will be developed that will exhibit efficient upconverted photoluminescence from the rare-earth ions (Er3/Tm3) doped into fluoride nanomatrix. Simultaneously, the Tb3/Dy3/Ho3 present at the shell will make them suitable as T2 contrast agents for MRI. Specific tumor targeting strategies will be developed by attaching targeting components like folic acid, cholesterol or cyclic-RGD to the surface of the nanoparticles. Functionalization of nanoparticles with [Pt(N3)2(OH)2(NH2-R)(py)] drug, which can be photoactivated by the blue light emitted from the nanoparticle core upon excitation at 980, will result in a novel phototheranostic anti-cancer agent. This system may allow a large degree of control of the therapeutic efficacy and ultimately lead to simultaneous diagnosis and treatment in clinical applications. The unique multidisciplinary approach adopted here which combines areas of nano-chemistry, spectroscopy and bio-imaging, is expected to lead to a disruptive change in the area of cancer research. The combination of these areas would allow for the first time the development of biocompatible “phototheranostic” agents for the simultaneous detection by MRI/optical imaging and cure of the cancer- affected tissues.
|year||authors and title||journal||last update|
Silvanose Biju, Juan Gallo, M. BaÃ±obre-LÃ³pez, Bella B. Manshian, Stefaan J. Soenen, Uwe Himmelreich, Luce Vanderâ€…Elst, Tatjana N. Parac-Vogt
A Magnetic Chameleon: Biocompatible Lanthanide Fluoride Nanoparticles with Magnetic Field Dependent Tunable Contrast Properties as a Versatile Contrast Agent for Low to Ultrahigh Field MRI and Optical Imaging in Biological Window
published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201801814
|Chemistry - A European Journal||2019-06-13|
Silvanose Biju, Tatjana Parac-Vogt
Recent Advances in Lanthanide Based Nano-architectures as Probes for Ultra High-Field Magnetic Resonance Imaging
published pages: , ISSN: 0929-8673, DOI: 10.2174/0929867325666180201110244
|Current Medicinal Chemistry 25||2019-06-13|
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The information about "MCNANO" are provided by the European Opendata Portal: CORDIS opendata.
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