SPICY

Spatial Integration in Cell Cytoskeleton

 Coordinatore COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore France [FR]
 Totale costo 1˙435˙000 €
 EC contributo 1˙435˙000 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2012-StG_20111109
 Funding Scheme ERC-SG
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-12-01   -   2017-11-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

 Organization address address: RUE LEBLANC 25
city: PARIS 15
postcode: 75015

contact info
Titolo: Dr.
Nome: Manuel
Cognome: Thery
Email: send email
Telefono: +33 4 38789126

FR (PARIS 15) hostInstitution 1˙435˙000.00
2    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

 Organization address address: RUE LEBLANC 25
city: PARIS 15
postcode: 75015

contact info
Titolo: Ms.
Nome: Haiyet
Cognome: Chebli
Email: send email
Telefono: +33 4 38 78 90 15

FR (PARIS 15) hostInstitution 1˙435˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

adhesions    context    ecm    compartments    spatial    multicellular    cells    actin    mechanical    centrosome    tissue    forces    dynamic    cell    time    peripheral    model    organisation    architectures    microtubule    microtubules    cues    polarity    space    polarisation   

 Obiettivo del progetto (Objective)

'The functional coherence in multicellular arrangements depends on each cell’s ability to adapt its internal organisation to the spatial configuration of their microenvironment. The asymmetric distributions of cell compartments and peripheral domains define the cell polarity. In multicellular animals, the establishment of cell polarity is mainly regulated by the cell’s adhesions to its neighbours and to the surrounding extracellular matrix (ECM). How cells integrate all these cues in space and time to determine the orientation of their polarity is a fundamental but unresolved problem. I hypothesize that the centrosome, which regulates the radial organisation of microtubules throughout the cell, plays a major role in the spatial integration of peripheral adhesive cues. Each type of adhesion induces the assembly of actin filaments into defined dynamic architectures. These architectures produce specific mechanical forces on microtubules. The net force displaces the centrosome-microtubule network and thereby repositions cell compartments and orients cell polarity. I propose to develop a new experimental strategy to manipulate cell adhesions in space and time. Using surface micropatterning and a new laser activation method, the spatial organisation of cell-cell and cell-ECM adhesions in complex multicellular context will be manipulated in real-time. We will quantify the dynamic rearrangements of actin and microtubule networks and measure intracellular forces. These results will allow us to develop a new physical model describing the stability of cell polarisation states. Finally, in the context of this model, we will explore the contribution of polarity reversal to critical morphogenetic events. This work will demonstrate that cell polarisation is a dynamic and mechanical event that is not the final outcome of tissue morphogenesis but instead an active mechanism allowing cells to continually probe and reconfigure tissue architecture.'

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