BRAINLEAP

A quantum leap: from a spike-centered brain universe to its underlying synaptic landscape

 Coordinatore UNIVERSITEIT ANTWERPEN 

 Organization address address: PRINSSTRAAT 13
city: ANTWERPEN
postcode: 2000

contact info
Titolo: Ms.
Nome: Anne
Cognome: Adams
Email: send email
Telefono: 3232653028
Fax: 3232653011

 Nazionalità Coordinatore Belgium [BE]
 Totale costo 3˙286˙599 €
 EC contributo 2˙478˙350 €
 Programma FP7-ICT
Specific Programme "Cooperation": Information and communication technologies
 Code Call FP7-ICT-2011-C
 Funding Scheme CP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-02-01   -   2016-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITEIT ANTWERPEN

 Organization address address: PRINSSTRAAT 13
city: ANTWERPEN
postcode: 2000

contact info
Titolo: Ms.
Nome: Anne
Cognome: Adams
Email: send email
Telefono: 3232653028
Fax: 3232653011

BE (ANTWERPEN) coordinator 0.00
2    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Célia
Cognome: Farge
Email: send email
Telefono: +33 4 72138859
Fax: +33 4 72 13 88 01

FR (PARIS) participant 0.00
3    NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN

 Organization address address: MARKWIESENSTRASSE 55
city: REUTLINGEN
postcode: 72770

contact info
Titolo: Mr.
Nome: Thomas
Cognome: Schweikert
Email: send email
Telefono: +49 7121 51530 885
Fax: +49 7121 51530 62

DE (REUTLINGEN) participant 0.00
4    THE HEBREW UNIVERSITY OF JERUSALEM.

 Organization address address: GIVAT RAM CAMPUS
city: JERUSALEM
postcode: 91904

contact info
Titolo: Ms.
Nome: Jane
Cognome: Turner
Email: send email
Telefono: +972 2 6586676
Fax: +972 72 2447007

IL (JERUSALEM) participant 0.00
5    UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

 Organization address address: Piazzale Aldo Moro 5
city: ROMA
postcode: 185

contact info
Titolo: Dr.
Nome: Cinzia
Cognome: Di Florio
Email: send email
Telefono: +39 06 4991 0793
Fax: +39 06 4969 0236

IT (ROMA) participant 0.00

Mappa


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computation    cognition    potentials    integration    brain    subthreshold    neuronal    synaptic    neurons    individual    brainleap    action   

 Obiettivo del progetto (Objective)

The richness of high-level cognitive and adaptive properties of the brain is reflected in the complexity of its anatomy and (electro)physiology. At the cellular level, evolution privileged for the central nervous system an analog distributed information storage and encoding, by plastic (graded) synapses and by their continuous temporal and spatial integration into firing rates. Beyond all-or-none action potentials, subthreshold synaptic and membrane electric activity in neurons disclose the details of single-neuron computations, neuronal identity and role, information processing and synaptic readout, as well as history-dependent dynamics of excitability and synaptic efficacy. The long-term experimental access to subthreshold activity of many neurons simultaneously, during behaviour and cognition, is then a requirement for the ultimate understanding of brain functions, its reverse engineering, as well as an unexplored alternative for neuroprosthetics.nProject BRAINLEAP develops a breakthrough, revolutionary technological approach to explore cognition and plasticity in cortical neuronal networks, and preliminary applies it in vitro and in awake behaving rodents and primates. BRAINLEAP will enable simultaneous, long-term, and independent recording and stimulation of the electrical activity from hundreds of individual mammalian neurons, with a quality that in practice matches the intracellular configuration. By allowing one to record (and stimulate) for very long times, synaptic- and action-potentials from individual neurons, in the context of specific sensorimotor integration tasks, the leap we propose might ultimately shift current paradigms and theories, from spike-centred computation to its underlying subthreshold synaptic potentials computation.

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