INVIVOSYNAPSE

Cellular determinants of neuronal plasticity on the level of single synapses in vivo

Coordinatore	TECHNISCHE UNIVERSITAET MUENCHEN    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Germany [DE]
Totale costo	2˙404˙800 €
EC contributo	2˙404˙800 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2012-ADG_20120314
Funding Scheme	ERC-AG
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-05-01   -   2018-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITAET MUENCHEN  Organization address address: Arcisstrasse 21 city: MUENCHEN postcode: 80333 contact info Titolo: Ms. Nome: Ulrike Cognome: Ronchetti Email: send email Telefono: +49 89 289 22616 Fax: +49 89 289 22620	DE (MUENCHEN)	hostInstitution	2˙404˙800.00
2	TECHNISCHE UNIVERSITAET MUENCHEN  Organization address address: Arcisstrasse 21 city: MUENCHEN postcode: 80333 contact info Titolo: Prof. Nome: Arthur Cognome: Konnerth Email: send email Telefono: +49 89 4140 3351 Fax: +49 89 4140 3352	DE (MUENCHEN)	hostInstitution	2˙404˙800.00

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 Obiettivo del progetto (Objective)

'The search for the fundamental mechanisms of learning and experience-dependent memory formation in the brain has long been a central quest in neuroscience. The neocortex is a particularly relevant region for plasticity because it is involved in sensory, motor, and cognitive tasks with strong learning components. However, despite many years of intensive research our knowledge of the neuronal mechanisms of plasticity on the level of single synapses in the intact living brain is still very limited. Here I propose the use of cutting edge technology, including the ultrasensitive LOTOS procedure of in vivo two-photon calcium imaging that was developed in our laboratory, to investigate for the first time the functional properties and the plasticity of signal synapses in auditory cortical pyramidal neurons of layers 2/3, 4 and 5 in vivo. For the study of the cellular determinants of synaptic plasticity we will focus on an associative learning paradigm underlying cued fear conditioning. Importantly, this paradigm can be rapidly and effectively induced not only in awake, but also in anesthetized animals and is therefore ideally suited for these studies. In addition to a comprehensive analysis of wild type animals, we will perform experiments in mouse models of Alzheimer’s disease (AD), aiming to identify the cellular cause of the devastating impairment of memory formation observed in patients suffering from AD.'