MERIT

Mutanome Engineered RNA Immuno-Therapy

 Coordinatore BIONTECH AG 

 Organization address address: HOLDERLINSTRASSE 8
city: Mainz
postcode: 55131

contact info
Titolo: Prof.
Nome: Ugur
Cognome: Sahin
Email: send email
Telefono: +49 613157627014
Fax: +49 613157627028

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://merit-consortium.eu
 Totale costo 7˙794˙995 €
 EC contributo 5˙964˙250 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2013-INNOVATION-2
 Funding Scheme CP-FP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-06-01   -   2016-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    BIONTECH AG

 Organization address address: HOLDERLINSTRASSE 8
city: Mainz
postcode: 55131

contact info
Titolo: Prof.
Nome: Ugur
Cognome: Sahin
Email: send email
Telefono: +49 613157627014
Fax: +49 613157627028

DE (Mainz) coordinator 4˙456˙750.00
2    INSTITUT GUSTAVE ROUSSY

 Organization address address: Rue Camille Desmoulins 39
city: VILLEJUIF
postcode: 94805

contact info
Titolo: Mr.
Nome: Arnauld
Cognome: Forest
Email: send email
Telefono: 33142116604
Fax: +33 142116160

FR (VILLEJUIF) participant 453˙750.00
3    VRIJE UNIVERSITEIT BRUSSEL

 Organization address address: PLEINLAAN 2
city: BRUSSEL
postcode: 1050

contact info
Titolo: Mr.
Nome: Nik
Cognome: Claesen
Email: send email
Telefono: 3226292210
Fax: 3226293640

BE (BRUSSEL) participant 401˙250.00
4    UPPSALA UNIVERSITET

 Organization address address: SANKT OLOFSGATAN 10 B
city: UPPSALA
postcode: 751 05

contact info
Titolo: Mrs.
Nome: Pirkko
Cognome: Boox
Email: send email
Telefono: +46 18 471 4815
Fax: +46 18 471 4808

SE (UPPSALA) participant 337˙500.00
5    UNIVERSITAET ZUERICH

 Organization address address: Raemistrasse 71
city: ZURICH
postcode: 8006

contact info
Titolo: Dr.
Nome: Steve
Cognome: Pascolo
Email: send email
Telefono: +41 44 63 42877
Fax: +4144 63 42872

CH (ZURICH) participant 315˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

clinical    negative    patient    cancer    innovative    therapeutics    mutations    shared    rna    therapeutic    patents    vaccines    immunotherapy    tumour    merit    triple    breast    signature    antigens    patients    generation    individual    grade   

 Obiettivo del progetto (Objective)

'The Mutanome Engineered RNA Immuno-Therapy (MERIT) project aims to clinically translate and industrially validate a pioneering RNA-based immunotherapy approach to target the individual tumour antigen signature. MERIT focuses on previous inventions, fits into the overall business and innovation needs of the partners, and addresses triple-negative breast cancer patients with high medical need. The MERIT concept, including patents and potential products, was developed using EU FP6 funding. The innovative therapeutics will pave the way for generation of scientific knowledge and technologies and will stimulate the development of new products, tools, patents, and innovative marketable applications. The concept behind MERIT is to implement a highly innovative Next-Generation-Immunotherapy drug platform enabling Next–Generation-Sequencing-guided stratified medicine and clinical-grade individualized RNA vaccines. Every patient’s tumour expresses many shared tumour-specific antigens and bears a highly individual molecular “signature” comprising 10’s to 100’s of non-synonymous mutations, many of which are immunogenic. We will use clinical-grade RNA to produce a) a warehouse of therapeutic vaccines targeting shared antigens and b) custom therapeutic vaccines targeting patient-specific mutations. Upon success, partner BioNTech will move the therapeutics to advanced clinical trials and commercial applications for the benefit of triple negative breast cancer patients and other solid tumours.'

Altri progetti dello stesso programma (FP7-HEALTH)

NEUROGRAFT (2012)

Development of Functionalised Cell Seeded Bioartificial Organ for Transplantation in Nerve Repair

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ENCITE (2008)

European Network for Cell Imaging and Tracking Expertise

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R-GNOSIS (2011)

Resistance in Gram-Negative Organisms: Studying Intervention Strategies

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