GERMLINE LONGEVITY

Germline-mediated regulation of lifespan in worms and fish

Coordinatore	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.    more  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Mrs. Nome: Waltraut Cognome: Bräunig Email: send email Telefono: +49 221 37970 230 Fax: +49 221 37970 800
Nazionalità Coordinatore	Germany [DE]
Totale costo	168˙794 €
EC contributo	168˙794 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-IIF
Funding Scheme	MC-IIF
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-11-01   -   2015-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Mrs. Nome: Waltraut Cognome: Bräunig Email: send email Telefono: +49 221 37970 230 Fax: +49 221 37970 800	DE (MUENCHEN)	coordinator	168˙794.40

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 Obiettivo del progetto (Objective)

'Trade-offs between reproduction and lifespan are observed in many organisms, however little is known about their underlying molecular and cellular mechanisms. In C. elegans, when germ cell precursors are removed by laser microsurgery, animals live up to 60% longer than normal. This longevity is not a simple consequence of sterility, as removing the entire gonad does not extend lifespan, suggesting that the germline and somatic gonad produce opposing signals that are pro-aging and anti-aging, respectively. Molecular genetic studies suggested that proliferating germline stem cells produce pro-aging effects. Recent studies revealed that lifespan extension upon reduced germline activities depends on the functions of several transcription factors, which regulate lipolysis, fatty acid desaturation and autophagy in somatic cells. Although a clearer picture of the anti-aging activities in somatic cells is emerging, the origin and characteristics of the pro-aging signals in the proliferating germline stem cells is totally unknown. In addition, the direct involvement of germ cells and/or germline stem cells in vertebrate lifespan has not been addressed. Using germline-specific knockdown system and transcriptome data in germline, I will perform RNAi screening and identify the signal emanating from germline stem cells to regulate lifespan in C. elegans. In parallel, I will use a vertebrate model medaka (Oryzias latipes) for comparative analysis of germline longevity, since germline stem cells and several germline mutants are well characterized. I will examine the lifespan, stress resistance, gene expression and metabolic change using several germline mutants. These studies will not only greatly contribute to the further understanding of germline longevity pathway but also should shed light on whether this pathway is conserved in vertebrates. This work will potentially contribute to a better understanding of the relationship between reproduction and lifespan in humans.'