PLANTAGEING

Deciphering the regulatory role of reactive oxygen species in plant ageing through an integrative genetics and genomics approach

Coordinatore	INSTITUTE OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY    more  Organization address address: Ruski Bulevard 105 city: PLOVDIV postcode: 4000 contact info Titolo: Dr. Nome: Tsanko Cognome: Gechev Email: send email Telefono: +359 32261526
Nazionalità Coordinatore	Bulgaria [BG]
Totale costo	73˙500 €
EC contributo	73˙500 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-IRSES
Funding Scheme	MC-IRSES
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-11-01   -   2017-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUTE OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY  Organization address address: Ruski Bulevard 105 city: PLOVDIV postcode: 4000 contact info Titolo: Dr. Nome: Tsanko Cognome: Gechev Email: send email Telefono: +359 32261526	BG (PLOVDIV)	coordinator	50˙400.00
2	UNIVERSITAET POTSDAM  Organization address address: AM NEUEN PALAIS 10 city: POTSDAM postcode: 14469 contact info Titolo: Dr. Nome: Regina Cognome: Gerber Email: send email Telefono: +49 331 9771080 Fax: +49 331 9771298	DE (POTSDAM)	participant	23˙100.00

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 Obiettivo del progetto (Objective)

'Plant senescence is a genetically controlled process modulated by environmental factors. A number of genes that influence ageing have been identified over the recent years; while mutations in most of them accelerate senescence, some delay senescence and thus extend lifespan. Experimental evidence strongly indicates that many more genes than functionally characterized so far contribute to the control of plant ageing. Moreover, very little is currently known about how these genes interact and to what extent developmental signals, environmental factors, phytohormones, and in particular the circadian clock modulate their activity and interactions. Recent research shows that reactive oxygen species (ROS) play a critical role in the control of senescence. The aim of this project therefore is to uncover new elements of the ROS regulatory pathway that modulate senescence in Arabidopsis thaliana and to unravel the mechanisms by which these genes interact with each other and with the internal clock. Mutants with accelerated and delayed senescence, previously isolated by our teams, will be subjected to genetic, genomic, and biochemical analyses. Identification of the mutated genes causing the altered senescence, molecular analysis by RNAseq and qRT-PCR, proteome and metabolome profiling will help to understand how these genes regulate lifespan. Staff exchange is of crucial importance to the success of the project. The Bulgarian partner is an expert in ROS signaling, the German collaborator has expertise in transcriptional regulation of ROS-related genes, and the New Zealand partner brings in knowledge about the genetics and physiology of ageing and ROS - circadian clock interactions. Thus, the European and New Zealand partners mutually complement each other in their expertise and capabilities. Unraveling the genetic mechanisms of plant ageing and lifespan regulation is of both, fundamental and practical importance for generating crops with improved yield and shelf life.'