ROBUST
"Evolution of a new stable phenotype: a genetic, developmental and behavioural analysis"
| Coordinatore | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie. |
| Nazionalità Coordinatore | France [FR] |
| Totale costo | 1˙386˙660 € |
| EC contributo | 1˙386˙660 € |
| Programma | FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | ERC-2013-StG |
| Funding Scheme | ERC-SG |
| Anno di inizio | 2014 |
| Periodo (anno-mese-giorno) | 2014-02-01 - 2019-01-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange 3 contact info |
FR (PARIS) | hostInstitution | 1˙386˙660.00 |
| 2 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange 3 contact info |
FR (PARIS) | hostInstitution | 1˙386˙660.00 |
Mappa
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Obiettivo del progetto (Objective)
'How robust phenotypes evolve despite developmental noise remains unclear. Individuals from natural populations usually display more stable phenotypes than laboratory mutants and hybrids. This suggests that there are genetic mechanisms that stabilize phenotypes and that these differ between isolated populations. We want to address here an unexplored yet fundamental question in biology: how does a stable phenotype appear during evolution? We will focus on the evolution of a new genital sensory organ pattern in Drosophila santomea. We aim to better characterize the molecular mechanisms that stabilize this recently evolved phenotype. Our goal is three-fold: (1) characterize and compare the development of these structures in D. santomea and its closely-related species, (2) identify the underlying genes and mutations that act collectively to produce a robust phenotype in pure species, and (3) unveil the selective forces at play on this evolved phenotype. Our combination of various powerful approaches in a tractable model system should provide important insights and concrete molecular data on phenotypic robustness and evolution. My PhD on Drosophila sensory organ development and my post-doc on the delicate genetics of Drosophila evolution have placed me in a unique position to successfully tackle this far-reaching research program.'