OPTIBIOCAT
Optimized esterase biocatalysts for cost-effective industrial production
| Coordinatore | UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II.
Organization address
address: Corso Umberto I 40 contact info |
| Nazionalità Coordinatore | Italy [IT] |
| Totale costo | 9˙109˙854 € |
| EC contributo | 6˙851˙846 € |
| Programma | FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology |
| Code Call | FP7-KBBE-2013-7-single-stage |
| Funding Scheme | CP-TP |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-12-01 - 2017-11-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II.
Organization address
address: Corso Umberto I 40 contact info |
IT (NAPOLI) | coordinator | 832˙800.00 |
| 2 |
LULEA TEKNISKA UNIVERSITET
Organization address
address: University Campus, Porsoen contact info |
SE (LULEA) | participant | 754˙537.50 |
| 3 |
TAROS CHEMICALS GMBH & CO KG
Organization address
address: Emil-Figge-Str. 76A contact info |
DE (Dortmund) | participant | 489˙440.00 |
| 4 |
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Organization address
address: Rue De L'Universite 147 contact info |
FR (PARIS CEDEX 07) | participant | 486˙348.80 |
| 5 |
HELSINGIN YLIOPISTO
Organization address
address: YLIOPISTONKATU 4 contact info |
FI (HELSINGIN YLIOPISTO) | participant | 477˙680.00 |
| 6 |
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Organization address
address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS contact info |
NL (AMSTERDAM) | participant | 450˙410.00 |
| 7 |
CHALMERS TEKNISKA HOEGSKOLA AB
Organization address
address: - contact info |
SE (GOETEBORG) | participant | 446˙022.80 |
| 8 |
PROTEONIC BV
Organization address
address: NIELS BOHRWEG 11-13 contact info |
NL (LEIDEN) | participant | 439˙806.40 |
| 9 |
DYADIC NEDERLAND BV
Organization address
address: NIEUWE KANAAL 7 S contact info |
NL (Wageningen) | participant | 435˙100.00 |
| 10 |
SUPREN GMBH
Organization address
address: JOSEPH-VON-FRAUNHOFER-STR. 20 contact info |
DE (DORTMUND) | participant | 413˙000.00 |
| 11 |
NZYTECH LDA
Organization address
address: ESTRADA DO PACO DO LUMIAR CAMPUS DO LUMIAR EDIFICIO E - R/C contact info |
PT (LISBOA) | participant | 385˙200.00 |
| 12 |
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Organization address
address: SCHLOSSPLATZ 2 contact info |
DE (MUENSTER) | participant | 349˙302.00 |
| 13 |
CLEA TECHNOLOGIES BV
Organization address
address: DELFTECHPARK 34 contact info |
NL (DELFT) | participant | 282˙607.50 |
| 14 |
KORRES S.A. NATURAL PRODUCTS (KORRES ANONIMI ETERIA FYSIKA PROIONTA)
Organization address
address: 57th Km ATHENS-LAMIA NATIONAL ROAD contact info |
EL (INOFYTA) | participant | 232˙759.60 |
| 15 |
BIOCOM
Organization address
address: LUTZOWSTRASSE 33-36 contact info |
DE (BERLIN) | participant | 231˙631.00 |
| 16 |
ServiceXS BV
Organization address
address: Plesmanlaan 1.d contact info |
NL (Leiden) | participant | 145˙200.40 |
Mappa
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Obiettivo del progetto (Objective)
'OPTIBIOCAT is a 48 months project aimed at developing biocatalysts based on feruloyl esterases (FAEs) and glucuronoyl esterases (GEs) for production of phenolic fatty- and sugar- esters with antioxidant activity for cosmetic industry, expanding the number/type of industrial biotransformations. Selected FAEs and GEs available within the consortium will be improved for their thermo- and solvent- resistance and substrate specificity by site-directed mutagenesis and directed evolution. Novel enzymes will be discovered by mining for new genes from available genomes. An inventory of novel FAEs and GEs will be developed including 50 fungal and 500 bacterial esterases, 25 site-directed and 20 directed evolved mutants. Enzymatic performances will be optimized to enhance the yield (up to the theoretical yield of 100%) and productivity (up to 0.5-1 g/l/h) of reactions giving the main targeted antioxidants: butyl ferulate, p-coumarate, caffeate, sinapate and 5-O-(trans-feruloyl)-arabinofuranose (using FAEs), glucuronate and benzyl glucuronate (using GEs). FAEs and GEs will be also tested for production of other compounds with improved biological activity and properties of hydrophilicity/hydrophobicity for cosmetic applications. Cost-effective methods will be developed for production of the new biocatalysts, in the g/L scale, and for their technical application to produce antioxidants for cosmetic industry, up to 20L. Enzyme immobilization will increase their recyclability up to ten cycles. The ability of the developed catalysts to work in conditions miming the industrial ones with reduced use of solvents and lower temperature than the chemical routes will be demonstrated. The techno-economic viability and environmental friendliness will be assessed considering a full industrial scale scenario. OPTIBIOCAT involves a highly skilled and multidisciplinary partnership of 16 partners from 8 EU countries, and it is a strongly industry driven project through the participation of 8 SMEs and 1 large company.'
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