TOXKINBIO

Toxicokinetics and biotransformation in aquatic invertebrates

 Coordinatore UNIVERSITY OF YORK 

 Organization address address: HESLINGTON
city: YORK NORTH YORKSHIRE
postcode: YO10 5DD

contact info
Titolo: Ms.
Nome: Caroline
Cognome: Moore
Email: send email
Telefono: 441904000000

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-CIG
 Funding Scheme MC-CIG
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-03-01   -   2018-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITY OF YORK

 Organization address address: HESLINGTON
city: YORK NORTH YORKSHIRE
postcode: YO10 5DD

contact info
Titolo: Ms.
Nome: Caroline
Cognome: Moore
Email: send email
Telefono: 441904000000

UK (YORK NORTH YORKSHIRE) coordinator 100˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

small    organisms    quantify    toxicokinetics    model    pathways    pharmaceuticals    sensitivity    want    species    selected    invertebrates    aquatic    biotransformation    chemicals    toxicokinetic    differences   

 Obiettivo del progetto (Objective)

'Pesticides, pharmaceuticals and other chemicals support our modern standard of life, but their use can have detrimental impacts on our environment. We want to study the uptake, biotransformation and elimination (toxicokinetics) of pharmaceuticals in aquatic invertebrates. We aim to identify and model biotransformation pathways in four different species. Studying the comparative toxicokinetics of small, aquatic invertebrates is of great interest because it contributes to understanding evolutionary and environmental mechanisms and causes of differences in species sensitivity to chemicals.

We want to apply a cutting edge analytical method to discover and quantify biotransformation products and pathways of pharmaceuticals (Ibuprofen, Fluoxetine, Carbamazepine, Venlafaxine) in small aquatic invertebrates (Daphnia magna, Chironomus riparius, Hyalella azteca, Lymnaea stagnalis).We selected pharmaceuticals which are frequently detected in aquatic systems, have known adverse effects on aquatic invertebrates and are metabolised in humans. Test organisms are cultured and were selected based on their importance in chemical testing (ecotoxicology) as well as their diversity in respiratory strategy and phylogeny.

Extracts of exposed and control organisms are analysed using high resolution mass spectrometry complemented by expert systems for the prediction of transformation pathways and products. We will carry out toxicokinetic experiments where we measure concentrations of parent compound and biotransformation products in the organism at different times during the experiment. A pulsed exposure design ensures efficient measurement and calibration of the toxicokinetic model consisting of a set of differential equations. We hope to find novel biotransformation pathways and will search for patterns in toxicokinetic parameters. Toxicokinetic differences between species will help to understand sensitivity to synthetic chemicals and quantify the importance of biotransformation.'

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