FUSIMAGINE

A new neuroimaging modality: from bench to bedside

 Coordinatore INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) 

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 Nazionalità Coordinatore France [FR]
 Totale costo 2˙497˙603 €
 EC contributo 2˙497˙603 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2013-ADG
 Funding Scheme ERC-AG
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-05-01   -   2019-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Dr.
Nome: Mickaël
Cognome: Tanter
Email: send email
Telefono: +33 1 80 96 30 68
Fax: +33 1 80963355

FR (PARIS) hostInstitution 2˙497˙603.00
2    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Mrs.
Nome: Isabelle
Cognome: Pires
Email: send email
Telefono: 33143622724
Fax: 33143622701

FR (PARIS) hostInstitution 2˙497˙603.00

Mappa


 Word cloud

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imaging    clinical    fmri    scanners    time    provides    modality    adults    functional    breakthrough    small    fundamental    bone    deep    techniques    brain    fus    fps    diagnosis    neuroscience    ultrasound    real   

 Obiettivo del progetto (Objective)

'NeuroImaging systems are invaluable tools in the understanding of the brain both for fundamental research and clinical diagnosis. However, recent improvements in deep brain imaging technology have been somewhat limited because most of them are based on incremental innovation of mature techniques (EEG, PET and fMRI) instead of breakthrough. In FUSIMAGINE, a genuinely new functional brain imaging modality will be developed and validated whose performances could have a major impact in neuroscience from fundamental research to clinical applications. This new modality is based on the use of ultrafast ultrasound scanners able to reach more than 10 000 frames per second (fps) compared to the usual 50 fps in conventional ultrasound scanners. This concept relies on compounded plane wave transmissions introduced by my team and demonstrates up to 100-fold increase in the sensitivity of blood flow measurements. It enables to image the subtle hemodynamic changes in small brain vessels and thus brain activity thanks to neurovascular coupling. Functional Ultrasound (fUS by analogy to fMRI) is a real breakthrough in brain imaging as our project will demonstrate that: in neuroscience, fUS provides a unique real time, portable and deep brain functional imaging technique for awake and even freely moving small animal imaging, moreover with unprecedented spatiotemporal resolution (~100µm, 50ms). in clinical diagnosis, fUS provides a unique bedside neuro-imaging system of newborns brain activity through the fontanel window. Such real time system will permit to monitor and better understand neonatal seizures and hemorrhages. On adults, fUS provides a unique functional imaging modality during neurosurgery to predict the cortical mapping remodeling resulting of tumor development (such as low-grade gliomas). Finally, new adaptive skull bone correction techniques implemented on the system will enable us to perform non invasive transcranial fUS imaging on human adults through the temple bone.'

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