GROWSPERM

Development of in vitro and in vivo strategies to avoid and cure male infertility

 Coordinatore Academisch Medisch Centrum bij de Universiteit van Amsterdam 

 Organization address address: MEIBERGDREEF 9
city: AMSTERDAM
postcode: 1105AZ

contact info
Titolo: Ms.
Nome: Eugenie
Cognome: Quartier
Email: send email
Telefono: 31205666188

 Nazionalità Coordinatore Netherlands [NL]
 Totale costo 2˙949˙521 €
 EC contributo 2˙949˙521 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-ITN
 Funding Scheme MC-ITN
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-05-01   -   2018-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    Academisch Medisch Centrum bij de Universiteit van Amsterdam

 Organization address address: MEIBERGDREEF 9
city: AMSTERDAM
postcode: 1105AZ

contact info
Titolo: Ms.
Nome: Eugenie
Cognome: Quartier
Email: send email
Telefono: 31205666188

NL (AMSTERDAM) coordinator 682˙722.94
2    VRIJE UNIVERSITEIT BRUSSEL

 Organization address address: PLEINLAAN 2
city: BRUSSEL
postcode: 1050

contact info
Titolo: Mr.
Nome: Nik
Cognome: Claesen
Email: send email
Telefono: +32 2 629 2210
Fax: +32 2 629 3640

BE (BRUSSEL) participant 576˙035.50
3    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Prof.
Nome: Olle
Cognome: Söder
Email: send email
Telefono: 46851775124

SE (STOCKHOLM) participant 519˙850.30
4    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

 Organization address address: SCHLOSSPLATZ 2
city: MUENSTER
postcode: 48149

contact info
Nome: Hanna
Cognome: Becker
Email: send email
Telefono: +49 251 83
Fax: +49 251 8354800

DE (MUENSTER) participant 444˙137.75
5    THE UNIVERSITY OF EDINBURGH

 Organization address address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL

contact info
Titolo: Dr.
Nome: Rod
Cognome: Mitchell
Email: send email
Telefono: 441312000000
Fax: +44 0131 242 6441

UK (EDINBURGH) participant 285˙056.62
6    LEAD PHARMA HOLDING BV

 Organization address address: TRANSISTORWEG 5
city: NIJMEGEN
postcode: 6534 AT

contact info
Titolo: Mrs.
Nome: Silvy
Cognome: Van Tuijl
Email: send email
Telefono: 31412782999

NL (NIJMEGEN) participant 236˙861.45
7    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

 Organization address address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS
city: AMSTERDAM
postcode: 1011 JV

contact info
Titolo: Mr.
Nome: Don
Cognome: Van Velzen
Email: send email
Telefono: +31 30 2121800
Fax: +31 30 2121865

NL (AMSTERDAM) participant 204˙856.75

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

patients    vivo    therapeutic    stem    young    fertility    cell    vitro    germ    scientists    testis    interventions    strategies    biology    infertility    sperm    sscs    male    network    train    human    cells    individual   

 Obiettivo del progetto (Objective)

'In many European countries at least 20% of young men exhibit sperm parameters below the lower WHO reference level and this will affect their fertility. Male infertility has a dramatic impact on the individual and couple’s psychological and social well-being and results in significant healthcare costs. Currently male patients that do not produce sperm have no therapeutic options to father children. Different therapeutic interventions for male infertility have to be developed depending on the severity of germ cell deficits in individual patients. In cases where undifferentiated germ cells are present in the testis, strategies based on sperm development from spermatogonial stem cells (SSCs) in vitro or in vivo need to be established. However, if no germ cells are present in the testis, somatic cells of such patients will be the only option from which to develop their own sperm. Development of these potential therapies requires detailed understanding of the entire process of sperm production from stem cells through to functional sperm. This information is still incomplete and fragmented. The current proposal seeks to train young scientists in a network that joins together the complementary knowledge and expertise of several public and private EU partners from disciplines of physiology, cell biology, molecular biology, chemistry and medicine in the field of male reproduction to investigate three strategies for sperm development: (1) propagation of human SSCs in vitro followed by their transplantation, (2) sperm development in vitro from stem cells or early germ cells, (3) sperm development in human testis tissue grafts in vivo. By coaching young scientists in this inter-sectorial and multidisciplinary network, we will train the next generation of researchers within the EU who are then primed to become leaders in the field of male fertility that continue to investigate basic science and translational aspects leading to novel interventions and clinical applications.'

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