CUREHLH

"European initiative to improve knowledge, treatment and survival of haemophagocytic syndromes in children"

 Coordinatore UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF 

 Organization address address: Martinistrasse 52
city: HAMBURG
postcode: 20246

contact info
Titolo: Dr.
Nome: Kai
Cognome: Lehmberg
Email: send email
Telefono: +49 40 7410 54209
Fax: +49 40 7410 54601

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://www.uke.de/curehlh
 Totale costo 3˙917˙550 €
 EC contributo 2˙994˙942 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-06-01   -   2011-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF

 Organization address address: Martinistrasse 52
city: HAMBURG
postcode: 20246

contact info
Titolo: Dr.
Nome: Kai
Cognome: Lehmberg
Email: send email
Telefono: +49 40 7410 54209
Fax: +49 40 7410 54601

DE (HAMBURG) coordinator 0.00
2    AZIENDA OSPEDALIERO-UNIVERSITARIA ANNA MEYER

 Organization address address: VIALE PIERACCINI 24
city: FIRENZE
postcode: 50139

contact info
Titolo: Dr.
Nome: Massimo
Cognome: Braganti
Email: send email
Telefono: 0039-055-5662301
Fax: 0039-055-5662379

IT (FIRENZE) participant 0.00
3    FORSCHUNGSZENTRUM BORSTEL

 Organization address address: Parkallee 1-40
city: BORSTEL
postcode: 23845

contact info
Titolo: Ms.
Nome: Susann
Cognome: Schrader
Email: send email
Telefono: 0049(0)-40-4537188220
Fax: 0049(0)-40-4537188721

DE (BORSTEL) participant 0.00
4    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Annick
Cognome: Bertault
Email: send email
Telefono: 0033-1-40784901
Fax: 0033-1-40784998

FR (PARIS) participant 0.00
5    ISTITUTO GIANNINA GASLINI

 Organization address address: VIA GEROLAMO GASLINI 5
city: GENOVA
postcode: 16147

contact info
Titolo: Dr.
Nome: Patrizia
Cognome: Fabrizi
Email: send email
Telefono: 0039 010 563 6461
Fax: 0039 010 377 6590

IT (GENOVA) participant 0.00
6    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Mr.
Nome: Thomas
Cognome: Walstam
Email: send email
Telefono: 0046-8-51773487
Fax: 0046-8-51771774

SE (STOCKHOLM) participant 0.00
7    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

 Organization address address: The Old Schools, Trinity Lane
city: CAMBRIDGE
postcode: CB2 1TN

contact info
Titolo: Ms.
Nome: Dawn
Cognome: Barker
Email: send email
Telefono: +44-1223 333543
Fax: 0044-1223 332988

UK (CAMBRIDGE) participant 0.00
8    UNIVERSITA DEGLI STUDI DI BRESCIA

 Organization address address: Piazza Del Mercato 15
city: BRESCIA
postcode: 25121

contact info
Titolo: Prof.
Nome: Raffaele
Cognome: Badolato
Email: send email
Telefono: 0039 0303995717
Fax: 0039 0303388099

IT (BRESCIA) participant 0.00
9    UNIVERSITAETSKLINIKUM FREIBURG

 Organization address address: HUGSTETTER STRASSE 49
city: FREIBURG
postcode: 79106

contact info
Nome: Gerhard
Cognome: Henninger
Email: send email
Telefono: 0049-761-270-1920
Fax: -2969

DE (FREIBURG) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

patients    cytotoxicity    immune    treatment    toxic    data    disease    murine    unknown    defects    combined    scientists    haemophagocytic    children    pathophysiology    cytokines    toxicity    uncontrolled    diagnosis    rare    hlh    earlier    genetic    cells   

 Obiettivo del progetto (Objective)

'Haemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening inherited immune disorder of early childhood characterised by an uncontrolled immune response. Three disease causing genes have been identified in about half of the patients. Diagnosis is difficult, pathophysiology poorly understood, and treatment unsatisfactory with about 40% of the children dying from treatment failure or toxicity. All European scientists active in research and treatment of HLH have joined in a consortium to enforce collaboration, combine the various expertises, and provide access to material and data. In vitro studies and several murine models for HLH and diseases predisposing to HLH, will be used to get more insight into the pathophysiology of the diverse genetic defects. Studies will address the role of triggers and antigen-presenting cells, the influence of cytokines in the initiation and propagation of the uncontrolled immune response, the interaction of immune effector cells and soluble factors, and the mechanism of cytotoxicity in lymphocytes and natural killer cells. Data about geno-phenotype will be combined to evaluate how known and unknown genetic defects reflect on the clinical course and immunophenotype of the patients. A diagnostic algorithm, incorporating knowledge from the known defects, will be developed and optimised in all countries to facilitate earlier and reliable diagnosis, and to separate patients with unknown defects or acquired HLH. The identification of risk factors for treatment failure and toxicity will be used to design improved treatment strategies. An experimental treatment will be tested in a murine model and will be the basis for a less toxic treatment in the future. Earlier diagnosis, better insight into the pathophysiology, and development of less toxic treatments are the steps towards a higher cure rate in HLH. In a rare disease as HLH, only combined efforts on an European-wide level will be able to achieve these goals.'

Introduzione (Teaser)

Leading European immunologists teamed up to solve the enigma of haemophagocytic syndromes in children. By identifying triggering factors, exploring the role of cytokines and unveiling the mechanisms implicated in immune cell cytotoxicity, scientists wished to improve existing diagnostics and treatment options for patients.

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