FAST-XDR-DETECT

Development of a two-approach plate system for the fast and simultaneous detection of MDR and XDR M. tuberculosis

Coordinatore	PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE    more  Organization address address: Nationalestraat 155 city: ANTWERPEN postcode: 2000 contact info Titolo: Mr. Nome: Jef Cognome: Van Lint Email: send email Telefono: -2476457 Fax: -2476194
Nazionalità Coordinatore	Belgium [BE]
Totale costo	3˙639˙320 €
EC contributo	2˙695˙565 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-A
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-02-01   -   2012-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE  Organization address address: Nationalestraat 155 city: ANTWERPEN postcode: 2000 contact info Titolo: Mr. Nome: Jef Cognome: Van Lint Email: send email Telefono: -2476457 Fax: -2476194	BE (ANTWERPEN)	coordinator	0.00
2	ADMINISTRACION NACIONAL DE LABORATORIOS E INSTITUTOS DE SALUD DR. CARLOS G. MALBRAN  Organization address address: Avenida Velez Sarsfield 563 city: BUENOS AIRES postcode: 1281 contact info Titolo: Ms. Nome: Laura Cognome: Boveri Email: send email Telefono: -43133557 Fax: +54-11-43133600 ext 24	AR (BUENOS AIRES)	participant	0.00
3	CORPORACION CORPOGEN  Organization address address: CARRERA 5 NO 66A-34 city: BOGOTA postcode: DC contact info Titolo: Ms. Nome: Patricia Cognome: Del Portillo Email: send email Telefono: 57-1-3484609 Fax: -3484551	CO (BOGOTA)	participant	0.00
4	HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH  Organization address address: Inhoffenstrasse 7 city: BRAUNSCHWEIG postcode: 38124 contact info Titolo: Dr. Nome: Michael Cognome: Strätz Email: send email Telefono: -61812502 Fax: -61812781	DE (BRAUNSCHWEIG)	participant	0.00
5	HOSPITAL ZONAL ESPECIALIZADO DE AGUDOS Y CRONICOS DR. CETRANGOLO  Organization address address: Italia 1750 city: VICENTE LOPEZ postcode: 1602 contact info Titolo: Ms. Nome: Laura Cognome: Boveris Email: send email Telefono: -43133557 Fax: +54-11-43133600 ext 24	AR (VICENTE LOPEZ)	participant	0.00
6	LATVIJAS INFEKTOLOGIJAS CENTRS (INFECTOLOGY CENTER OF LATVIA)  Organization address address: LINEZERA IELA 3 city: RIGA postcode: 1006 contact info Titolo: Dr. Nome: Girts Cognome: Skenders Email: send email Telefono: 37167048249 Fax: 37167901014	LV (RIGA)	participant	0.00
7	LIONEX GMBH  Organization address address: Salzdahlumer Strasse 196 city: BRAUNSCHWEIG postcode: 38126 contact info Titolo: Prof. Nome: Mahavir Cognome: Singh Email: send email Telefono: -5312601217 Fax: -5312601110	DE (BRAUNSCHWEIG)	participant	0.00
8	SMITTSKYDDSINSTITUTET  Organization address address: Nobels vaeg 18 city: SOLNA postcode: 17182 contact info Titolo: Mr. Nome: Bengt-åke Cognome: Andersson Email: send email Telefono: -4572299 Fax: -344922	SE (SOLNA)	participant	0.00

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 Obiettivo del progetto (Objective)

'Tuberculosis (TB) continues being a leading cause of death due to a single infectious disease agent. The HIV/AIDS pandemic and the emergence of drug resistance are compounding factors that hinder the control of the disease. Associated with this problem is the emergence of multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, defined as strains resistant to at least isoniazid and rifampicin, the most valuable drugs in the treatment of the disease. More recently, the appearance of extensively drug resistant (XDR) strains has been reported. These strains, in addition to being MDR, are also resistant to key second-line drugs. Patients, especially HIV patients, harbouring XDR strains have virtually no treatment options. New and improved methods for fast detection of drug resistance are urgently needed. This project will develop a twofold-approach system for the fast and simultaneous detection of MDR and XDR strains based on a rapid phenotypic assay and a genotypic test. Colorimetric methods, which have been previously validated by our group for first-line drug susceptibility testing, will be developed for key second-line drugs involved in XDRTB. Once set up, these methods will be further elaborated for direct application to sputum specimens. The molecular tool will be based on a modification of the novel technology named detection of immobilized amplified product in one phase system. This single step amplification method will be developed in a versatile microtitre well strip format for detection first of MDR and then of XDR strains. The tools will be then validated in different settings and prospectively evaluated in target populations. The project will contribute to the currently available armamentarium for rapid detection of drug resistant TB and will introduce new tools for the detection of the recently-described and highly-lethal XDRTB. It will also contribute to our knowledge on the mechanisms of M. tuberculosis resistance to second-line drugs.'

Introduzione (Teaser)

European researchers are developing new assays to detect drug resistant strains of Mycobacterium tuberculosis.